A5024285185- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Systemic Lupus Erythematosus Research
- Gastroesophageal reflux and treatments
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal motility and disorders
- Pregnancy and preeclampsia studies
- Biliary and Gastrointestinal Fistulas
- Digestive system and related health
- Hepatocellular Carcinoma Treatment and Prognosis
- Neonatal Health and Biochemistry
- Metabolism and Genetic Disorders
- HIV/AIDS drug development and treatment
- Pancreatitis Pathology and Treatment
- Cholesterol and Lipid Metabolism
- Esophageal and GI Pathology
- Hepatitis Viruses Studies and Epidemiology
- Diabetes and associated disorders
- Drug-Induced Hepatotoxicity and Protection
University of Bologna
2013-2023
Policlinico S.Orsola-Malpighi
2010-2021
Ospedale per gli Infermi
2018
ASL Roma
2018
Gazi University
2018
University of Trento
2018
Creative Research Enterprises (United States)
2018
University of Modena and Reggio Emilia
2017
AbbVie (United States)
2017
Azienda Ospedaliero-Universitaria di Modena
2017
Primary biliary cholangitis (formerly called primary cirrhosis) can progress to cirrhosis and death despite ursodiol therapy. Alkaline phosphatase bilirubin levels correlate with the risk of liver transplantation or death. Obeticholic acid, a farnesoid X receptor agonist, has shown potential benefit in patients this disease.In 12-month, double-blind, placebo-controlled, phase 3 trial, we randomly assigned 217 who had an inadequate response found side effects unacceptable receive obeticholic...
Abstract The effect of achieving a sustained virological response (SVR) following interferon-α (IFNα) treatment on the clinical outcomes patients with HCV-related cirrhosis is unknown. In an attempt to assess risk liver-related complications, HCC and mortality in according IFNα treatment, retrospective database was developed including all consecutive HCV-related, histologically proven treated monotherapy between January 1992 December 1997. SVR undetectable serum HCV-RNA by PCR 24 weeks after...
Abstract The anti–hepatitis C virus (HCV) effect and safety of three different oral doses the cyclophilin inhibitor Debio 025 in combination with pegylated interferon-α2a (PEG IFN-α2a) were investigated a multicenter, randomized, double-blind, placebo-controlled escalating dose-ranging phase II study treatment-naïve patients chronic hepatitis C. Doses 200, 600, 1,000 mg/day PEG IFN-α2a 180 μg/week for 4 weeks compared monotherapy either or IFN-α2a. In genotypes 1 4, 600- 1,000-mg treatments...
To evaluate gallstone incidence and risk factors in a large population-based study.Gallstone factors, were evaluated by structured questionnaire physical examination, respectively, 9611 of 11 109 (86.5%) subjects who gallstone-free at the cross-sectional study.Six centers throughout Italy enrolled (5477 males, 4134 females, aged 30-79 years), 9517 whom included into analysis: 424 (4.4%) had gallstones 61 (0.6%) been cholecystectomized yielding cumulative 0.67% per year (0.66% 0.81% females)....
Alcohol addiction may induce its dependence through a mechanism involving opiate receptors and opioid peptides. For these reasons, we measured ACTH,β-lipotropin, β-endorphin in the plasma cerebrospinal fluid (CSF) of 29 alcohol addicts compared values with those found 8 normal volunteers. Although no significant differences existed peripheral concentrations 3 peptides, had levels CSF (mean±se, 29.4±4.5 fmol/ml) that were 3-fold lower than controls (98.4±10.5 fmol/ml; P<0.001) ACTH 4 times...
Berberine (1) is an alkaloid used widely in the treatment of several diseases. However, its physicochemical properties, pharmacokinetics, and metabolism remain unclear, conflicting data have been reported. In this study, main properties 1 metabolites were evaluated, including lipophilicity, solubility, pKa, albumin binding. A sensitive HPLC-ESIMS/MS method was developed validated to identify human plasma. This quantify their levels plasma healthy volunteers hypercholesterolemic patients...
Noninvasive markers would be useful for the assessment of portal hypertension (PH) and esophageal varices (EV) in patients with cirrhosis. The aim our study was to evaluate performance indocyanine green (ICG) retention test as a noninvasive marker PH EV, measured against gold standards (hepatic venous pressure gradient [HVPG] measurement upper endoscopy). We prospectively enrolled compensated cirrhosis referral unit. All underwent laboratory tests, abdominal ultrasound, gastrointestinal...
Phytosterols, besides hypocholesterolemic effect, present anti-inflammatory properties. Little information is available about their efficacy in Inflammatory Bowel Disease (IBD). Therefore, we have evaluated the effect of a mixture phytosterols on prevention/induction/remission murine experimental model colitis. Phytosterols were administered x os before, during and after colitis induction with Dextran Sodium Sulfate (DSS) mice. Activity Index (DAI), colon length, histopathology score,...
Several non-invasive tests (NITs) have been developed to diagnose oesophageal varices (EV), including the recent Baveno VI criteria rule out high-risk (HRV). Spleen stiffness measurement (SSM) with standard FibroScan® (SSM@50Hz) has evaluated. However, EV grading could be underestimated because of a ceiling threshold (75 kPa) SSM@50Hz. The aims were evaluate SSM by novel spleen-dedicated (SSM@100Hz) for diagnosis compared SSM@50Hz, other validated NITs and criteria.This prospective...
Little is known about the effects on fetus of ursodeoxycholic acid (UDCA) treatment for intrahepatic cholestasis pregnancy (ICP). Twenty ICP patients were given UDCA at 1.5 to 2 g/d, our knowledge highest dosage yet reported. Effects evaluated conjugated bile acids (BA) in amniotic fluid (15 20 patients) and umbilical cord serum obtained delivery (20 22 newborns), as compared with 10 untreated (amniotic fluid, 9 patients; serum, newborns). Liver function tests, BA enrollment then weekly...
Cholesterol gallstones are dissolved in man by chenodeoxycholic acid (CDCA) and ursodeoxycholic (UDCA). To test the comparative efficacy of these two cholelitholytic bile acids, 223 patients were randomly treated with either UDCA or CDCA at different doses: 7 to 8 mg per kg day 14 15 day. Efficacy factors influencing dissolution (dose, size stones, time) evaluated after 3, 6, 12 months treatment. was significantly more efficacious than 3 6 treatment, whereas months, no significant...
<b>Background:</b> Interferon may trigger autoimmune disorders, including hepatitis, in immunocompetent patients. To date, no such disorders have been described liver transplanted <b>Methods:</b> 9 of 44 patients who had receiving pegylated-interferon alpha-2b and ribavirin for at least 6 months hepatitis C virus (HCV) recurrence, developed graft dysfunction despite on-treatment HCV-RNA clearance all but one case. Laboratory, microbiological, imaging histological evaluations were performed...
Bile acid metabolism was investigated in 10 patients after cholecystectomy, gallstone patients, and control subjects. Diurnal variations of serum levels cholic chenodeoxycholic conjugates were not abolished by cholecystectomy. Cholic pool size significantly reduced cholecystectomised the fractional turnover rate intestinal degradation bile showed a significant increase. In fasting supersaturated cholesterol, though less than but, both, feeding resulted improvement cholesterol solubility...