A5003759928- Wnt/β-catenin signaling in development and cancer
- Skin and Cellular Biology Research
- Cancer-related gene regulation
- Connective tissue disorders research
- Body Contouring and Surgery
- RNA Research and Splicing
- Lymphatic System and Diseases
- Developmental Biology and Gene Regulation
Howard Hughes Medical Institute
2019-2020
Rockefeller University
2019-2020
Tissues rely on stem cells (SCs) for homeostasis and wound repair. SCs reside in specialized microenvironments (niches) whose complexities roles orchestrating tissue growth are still unfolding. Here, we identify lymphatic capillaries as critical SC-niche components. In skin, lymphatics form intimate networks around hair follicle (HF) SCs. When HFs regenerate, lymphatic-SC connections become dynamic. Using a mouse model, unravel secretome switch that controls behavior. Resting express...
To spatially co-exist and differentially specify fates within developing tissues, morphogenetic cues must be correctly positioned interpreted. Here, we investigate mouse hair follicle development to understand how morphogens operate closely spaced, fate-diverging progenitors. Coupling transcriptomics with genetics, show that emerging progenitors produce both WNTs WNT inhibitors. Surprisingly, however, instead of generating a negative feedback loop, the signals oppositely polarize,...