A5101788503- Retinal Development and Disorders
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- bioluminescence and chemiluminescence research
- Photoreceptor and optogenetics research
- CRISPR and Genetic Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
The University of Texas at Austin
2023-2024
National Institute of Neurological Disorders and Stroke
2024
National Institutes of Health
2024
McPherson College
2024
Smith-Kettlewell Eye Research Institute
2024
University of Wisconsin–Madison
2024
Northwestern University
2024
C1QL1 is expressed in a subset of cells the brain and likely has pleiotropic functions, including regulation neuron‐to‐neuron synapses. Research progress on C1QL proteins been slowed by dearth available antibodies. Therefore, we created novel knock‐in mouse line which an HA‐tag inserted into endogenous C1ql1 locus. We examined entire brain, identifying previously unappreciated nuclei expressing C1QL1, presumably neurons. By total numbers, however, large majority C1QL1‐expressing are...
In congenital stationary night blindness, type 2 (CSNB2)—a disorder involving the Ca v 1.4 (L-type) 2+ channel—visual impairment is mild considering that mediates synaptic release from rod and cone photoreceptors. Here, we addressed this conundrum using a knockout (KO) mouse knock-in (G369i KI) expressing non-conducting 1.4. Surprisingly, 3 (T-type) currents were detected in cones of G369i KI mice KO but not wild-type mouse, ground squirrels, macaque retina. Whereas are blind, exhibit normal...
In congenital stationary night blindness, type 2 (CSNB2)—a disorder involving the Ca v 1.4 (L-type) 2+ channel—visual impairment is mild considering that mediates synaptic release from rod and cone photoreceptors. Here, we addressed this conundrum using a knockout (KO) mouse knock-in (G369i KI) expressing non-conducting 1.4. Surprisingly, 3 (T-type) currents were detected in cones of G369i KI mice KO but not wild-type mouse, ground squirrels, macaque retina. Whereas are blind, exhibit normal...
In congenital stationary night blindness type 2 (CSNB2)—a disorder involving dysfunction of the Ca v 1.4 2+ channel—visual impairment is relatively mild considering that mediates synaptic transmission by rod and cone photoreceptors. Here, we addressed this conundrum using a knockout (KO) mouse knock-in (KI) expressing non-conducting mutant. Surprisingly, aberrant 3 currents were detected in cones KI KO but not wild-type mice. Cone synapses, which fail to develop mice, are present enlarged...
In congenital stationary night blindness type 2 (CSNB2)—a disorder involving the Ca v 1.4 (L-type) 2+ channel—visual impairment is mild considering that mediates synaptic release from rod and cone photoreceptors. Here, we addressed this conundrum using a knockout (KO) mouse knock-in (G369i KI) expressing non-conducting 1.4. Surprisingly, 3 (T-type) currents were detected in cones of G369i KI mice KO but not wild-type mouse, ground squirrel, macaque retina. Whereas are blind, exhibit normal...
In congenital stationary night blindness type 2 (CSNB2)—a disorder involving the Ca v 1.4 (L-type) 2+ channel—visual impairment is mild considering that mediates synaptic release from rod and cone photoreceptors. Here, we addressed this conundrum using a knockout (KO) mouse knock-in (G369i KI) expressing non-conducting 1.4. Surprisingly, 3 (T-type) currents were detected in cones of G369i KI mice KO but not wild-type mouse, ground squirrel, macaque retina. Whereas are blind, exhibit normal...
In congenital stationary night blindness type 2 (CSNB2)-a disorder involving the Cav1.4 (L-type) Ca2+ channel-visual impairment is mild considering that mediates synaptic release from rod and cone photoreceptors. Here, we addressed this conundrum using a knockout (KO) mouse knock-in (G369i KI) expressing non-conducting Cav1.4. Surprisingly, Cav3 (T-type) currents were detected in cones of G369i KI mice KO but not wild-type mouse, ground squirrel, macaque retina. Whereas are blind, exhibit...