David Krug

ORCID: 0000-0001-8811-5416
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About
Contact & Profiles
Research Areas
  • Breast Cancer Treatment Studies
  • Advanced Radiotherapy Techniques
  • Breast Lesions and Carcinomas
  • Advanced Breast Cancer Therapies
  • HER2/EGFR in Cancer Research
  • Breast Implant and Reconstruction
  • Brain Metastases and Treatment
  • Cancer Treatment and Pharmacology
  • Cardiac Arrhythmias and Treatments
  • Lung Cancer Diagnosis and Treatment
  • Management of metastatic bone disease
  • Cardiac pacing and defibrillation studies
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Cardiac electrophysiology and arrhythmias
  • Advances in Oncology and Radiotherapy
  • Cancer Diagnosis and Treatment
  • Radiomics and Machine Learning in Medical Imaging
  • Lung Cancer Treatments and Mutations
  • Medical Imaging Techniques and Applications
  • Cancer Genomics and Diagnostics
  • BRCA gene mutations in cancer
  • Glioma Diagnosis and Treatment
  • Lung Cancer Research Studies
  • Effects of Radiation Exposure

University Hospital Schleswig-Holstein
2010-2025

University of Lübeck
2010-2025

Universitätsklinik für Strahlentherapie
2015-2025

Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2015-2025

Universität Hamburg
2024-2025

University Medical Center Hamburg-Eppendorf
2024-2025

University Cancer Center Hamburg
2025

Heidelberg University
2015-2024

University Hospital Heidelberg
2015-2024

University of Rostock
2024

In clinically node-negative breast cancer patients, the INSEMA trial (NCT02466737) assessed non-inferiority of avoiding sentinel lymph node biopsy (SLNB) or axillary dissection (ALND). Here we present patient-reported outcomes (PROs) as a secondary endpoint.PROs were for patients with no surgery, SLNB alone, and ALND. Quality life (QoL) questionnaire EORTC QLQ-C30 its module (BR23) used at baseline (pre-surgery) 1, 3, 6, 12, 18 months after surgery. The QoL scores compared using repeated...

10.1016/j.eclinm.2022.101756 article EN cc-by EClinicalMedicine 2022-11-25

Abstract This yearʼs 18th St. Gallen (SG) consensus conference on the treatment of early breast cancer (SGBCC: International Breast Cancer Conference) focused practice-oriented questions. The individual situation and risk-benefit assessment were discussed in great detail. As previous years, a German working group leading experts presented results international SGBCC 2023 against background recommendations – especially updated Arbeitsgemeinschaft Gynäkologische Onkologie e. V. (AGO) for...

10.1055/a-2121-2495 article EN cc-by-nc-nd Geburtshilfe und Frauenheilkunde 2023-09-01

BackgroundWhether surgical axillary staging as part of breast-conserving therapy can be omitted without compromising survival has remained unclear.MethodsIn this prospective, randomized, noninferiority trial, we investigated the omission surgery compared with sentinel-lymph-node biopsy in patients clinically node-negative invasive breast cancer staged T1 or T2 (tumor size, ≤5 cm) who were scheduled to undergo surgery. We report here per-protocol analysis disease–free (the primary efficacy...

10.1056/nejmoa2412063 article EN New England Journal of Medicine 2024-12-12

<b><i>Introduction:</i></b> Each year the interdisciplinary AGO (Arbeitsgemeinschaft Gynäkologische Onkologie, German Gynecological Oncology Group) Breast Committee on Diagnosis and Treatment of Cancer provides updated state-of-the-art recommendations for early metastatic breast cancer. <b><i>Methods:</i></b> The evidence-based treatment cancer have been released in March 2024. <b><i>Results Conclusion:</i></b> This...

10.1159/000538596 article EN Breast Care 2024-01-01

Abstract Objective To update the practical guidelines for radiotherapy of patients with locoregional breast cancer recurrences based on current German interdisciplinary S3 2012. Methods A comprehensive survey literature using search phrases “locoregional recurrence”, “chest wall “local “regional and “breast cancer” was performed, limits “clinical trials”, “randomized “meta-analysis”, “systematic review”, “guidelines”. Conclusions Patients isolated in-breast or regional should be treated...

10.1007/s00066-015-0939-7 article EN cc-by Strahlentherapie und Onkologie 2016-03-01

Abstract Background Single-session high-dose stereotactic radiotherapy (radiosurgery) is a new treatment option for otherwise untreatable patients suffering from refractory ventricular tachycardia (VT). In the initial single-center case studies and feasibility trials, cardiac radiosurgery has led to significant reductions of VT burden with limited toxicities. However, full safety profile remains largely unknown. Methods/design this multi-center, multi-platform clinical trial which we plan...

10.1007/s00392-020-01650-9 article EN cc-by Clinical Research in Cardiology 2020-04-18
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