A5016181929- Primate Behavior and Ecology
- Malaria Research and Control
- Evolutionary Psychology and Human Behavior
- Animal Behavior and Reproduction
- Respiratory viral infections research
- Genetic diversity and population structure
- Parasite Biology and Host Interactions
- Human-Animal Interaction Studies
- Zoonotic diseases and public health
- Mosquito-borne diseases and control
- Genomics and Phylogenetic Studies
- Evolution and Paleontology Studies
- Animal Disease Management and Epidemiology
- Virology and Viral Diseases
- Reproductive tract infections research
- HIV Research and Treatment
- Wildlife Ecology and Conservation
- Influenza Virus Research Studies
- Vector-borne infectious diseases
- Viral Infections and Immunology Research
- Animal Vocal Communication and Behavior
- Complement system in diseases
- Syphilis Diagnosis and Treatment
National Geospatial-Intelligence Agency
2023-2024
Harvard University
2014-2022
Broad Institute
2019
Harvard University Press
2017-2019
University of Wisconsin–Madison
2017
University of New Mexico
2017
Makerere University
2017
Tufts University
2017
Animal Welfare Institute
2017
Evolutionary Genomics (United States)
2017
Respiratory viruses of human origin infect wild apes across Africa, sometimes lethally. Here we report simultaneous outbreaks two distinct respiratory viruses, metapneumovirus (MPV; Pneumoviridae: Metapneumovirus) and respirovirus 3 (HRV3; Paramyxoviridae; Respirovirus, formerly known as parainfluenza virus 3), in chimpanzee (Pan troglodytes schweinfurthii) communities the same forest Uganda December 2016 January 2017. The were absent before outbreaks, but each was present ill chimpanzees...
We describe a lethal respiratory outbreak among wild chimpanzees in Uganda 2013 for which molecular and epidemiologic analyses implicate human rhinovirus C as the cause. Postmortem samples from an infant chimpanzee yielded near-complete genome sequences throughout tract; other pathogens were absent. Epidemiologic modeling estimated basic reproductive number (R0) epidemic 1.83, consistent with common cold humans. Genotyping of 41 examination 24 published genomes subspecies across Africa...
Analysis of phylogenetic trees has become an essential tool in epidemiology. Likelihood-based methods fit models to phylogenies draw inferences about the phylodynamics and history viral transmission. However, these are often computationally expensive, which limits complexity realism phylodynamic makes them ill-suited for informing policy decisions real-time during rapidly developing outbreaks. Likelihood-free using deep learning pushing boundaries inference beyond constraints. In this paper,...
Malaria parasites, though widespread among wild chimpanzees and gorillas, have not been detected in bonobos. Here, we show that wild-living bonobos are endemically Plasmodium infected the eastern-most part of their range. Testing 1556 faecal samples from 11 field sites, identify high prevalence Laverania infections Tshuapa-Lomami-Lualaba (TL2) area, but at other locations across Congo. TL2 harbour P. gaboni, formerly only found chimpanzees, as well a potential new species, lomamiensis sp....
Respiratory illnesses have caused significant mortality in African great ape populations. While much effort has been given to identifying the responsible pathogens, little is known about factors that influence disease transmission or individual susceptibility. In Kanyawara community of wild chimpanzees, respiratory illness leading cause over 31 years, contributing 27% deaths. Deaths were common all age groups except juveniles. Over 22 years health observations, signs rare among infants and...
Abstract Analysis of phylogenetic trees has become an essential tool in epidemiology. Likelihood-based methods fit models to phylogenies draw inferences about the phylodynamics and history viral transmission. However, these are computationally expensive, which limits complexity realism phylodynamic makes them ill-suited for informing policy decisions real-time during rapidly developing outbreaks. Likelihood-free using deep learning pushing boundaries inference beyond constraints. In this...
Abstract Malaria pathogenesis is caused by the replication of Plasmodium parasites within red blood cells (RBCs) vertebrate host. This selective pressure has favored evolution protective polymorphisms in erythrocyte proteins, a subset which serve as cognate receptors for parasite invasion ligands. Recently, generation RBCs from immortalized hematopoietic stem (HSCs) offered more tractable system genetic manipulation and long‐term vitro culture, enabling elucidation functional determinants...
Abstract Chimpanzees ( Pan troglodytes ) harbor rich assemblages of malaria parasites, including three species closely related to P. falciparum (sub-genus Laverania ), the most malignant human parasite. Here, we characterize ecology and epidemiology infection in wild chimpanzee reservoirs. We used molecular assays screen fecal samples, collected longitudinally cross-sectionally from populations, for parasite mitochondrial DNA. found that parasitism has an early age onset varies seasonally...