A5102821076- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Optical Coherence Tomography Applications
- Glaucoma and retinal disorders
- Allergic Rhinitis and Sensitization
- Lymphatic System and Diseases
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Biochemical effects in animals
- Optical Imaging and Spectroscopy Techniques
- Retinopathy of Prematurity Studies
- Advanced Fluorescence Microscopy Techniques
- Surface Roughness and Optical Measurements
- Traffic and Road Safety
- Retinal Imaging and Analysis
- Laser Material Processing Techniques
- Acne and Rosacea Treatments and Effects
- Traumatic Ocular and Foreign Body Injuries
- Ocular Infections and Treatments
- Photoacoustic and Ultrasonic Imaging
- Dermatology and Skin Diseases
- Stress Responses and Cortisol
- Renal and Vascular Pathologies
- Olfactory and Sensory Function Studies
University of Cologne
2016-2025
University Hospital Cologne
2017-2025
Centrum für Integrierte Onkologie
2022
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2016-2018
Universitätsklinik für Augenheilkunde
2016
Immunologic graft rejection is the main complication after corneal transplant into pathologically prevascularized so-called high-risk eyes. The aim of this study was to evaluate whether ultraviolet (UV) light crosslinking can regress pathologic blood and lymphatic vessels thereby improve subsequent survival. Using murine model suture-induced neovascularization, we found that with UVA riboflavin regressed both preexisting significantly via induction apoptosis in vascular endothelial cells. In...
Abstract Meibomian glands (MG) are large sebaceous located below the tarsal conjunctiva and abnormalities of these cause gland dysfunction (MGD) which is responsible for evaporative dry eye disease (DED). Accurate MG segmentation a key prerequisite automated imaging based MGD related DED diagnosis. However, Automatic in infrared meibography challenging task due to image artifacts. A deep learning-based has been proposed directly learns features from training dataset without any...
Corneal neovascularization, in particular lymphangiogenesis, is a limiting factor corneal transplant survival. Novel treatment approaches focus on (selective) inhibition and regression of lymphatic vessels. Imaging clinically invisible vessels prerequisite for these strategies. Using murine model, this study investigates whether can be imaged using microscopic optical coherence tomography (mOCT).Corneal neovascularization was induced by intrastromal placement 11.0 nylon sutures one eye...
Lymphangiogenesis is essential for fluid homeostasis in vascularized tissues. In the normally avascular cornea, however, pathological lymphangiogenesis mediates diseases like corneal transplant rejection, dry eye disease, and allergy. So far, a physiological role primarily site such as cornea has not been described. Using mouse model of perforating injury that causes acute severe accumulation we show lymphatics transiently selectively invade regulate resolution edema. Pharmacological...
Corneal lymphatic vessels are clinically invisible because of their thin walls and clear lymph fluid. There is no easy established method for in vivo imaging corneal so far. In this study, we present a novel approach to visualize by injecting intrastromal fluorescein sodium.Six- eight-week-old female BALB/c mice were used the mouse model suture-induced neovascularization. Two weeks after suture placement, sodium was injected intrastromally. The fluorescein, taken up presumed vessels, then...
Meibomian Gland Dysfunction (MGD) is a leading cause of evaporative Dry Eye Disease (DED). This makes non-invasive meibography an important procedure in the clinical evaluation DED patients. Our purpose was to conduct lead-off investigation focused on practicality performing developing country, with limited access complex ophthalmic imaging systems, using custom meibographer, as step future comparative studies meibomian glands and Africa.
To compare differences in clinical dry eye features and meibomian gland health status between patients from rural urban populations Ghana.We examined 211 (rural=109, urban=102) participants with subjective symptoms. Tear film break -up time (TBUT), Schirmer's test ocular surface staining (OSS) were assessed. Symptoms evaluated using the SPEED II questionnaire. Meibomian glands (MG) right upper (UL) lower lids (LL) imaged a custom meibographer. MG area was determined by intensity threshold...
Die optische Kohärenztomografie (OCT) ist ein in vielen Bereichen der Augenheilkunde etabliertes Bildgebungsverfahren. Im 1. Teil zum Thema OCT werden technisch-physikalische Grundlagen Verständnis vermittelt. prinzipielle Arbeitsweise wird erläutert. zugrundeliegende Licht-Gewebe-Wechselwirkung sowie die OCT-Messtechnik beschrieben und verschiedene OCT-Verfahren vorgestellt. Komplexe physikalische Vorgänge dabei anschaulich dargestellt Formeln weitgehend vermieden. Hintergrundboxen laden zu...
Den Schwerpunkt dieses Artikels bildet die Vermittlung praktischen Wissens rund um optische Kohärenztomografie (OCT). Während in Teil 1 physikalischen Grundlagen vorgestellt wurden, werden hier praktische Aspekte für den Anwender erläutert, unabhängig vom verwendeten Gerätetyp oder Hersteller. Grundsätzliche Parameter und Einstellmöglichkeiten vorgestellt. Es wird hinterfragt, was ein OCT-Bild eigentlich zeigt wann bei der Interpretation Auswertung Vorsicht geboten ist. Typische Artefakte...
Den Schwerpunkt dieses Artikels bildet die Vermittlung praktischen Wissens rund um optische Kohärenztomografie (OCT). Während in <ext-link href="http://doi.org/10.1055/s-0042-113337" doi="10.1055/s-0042-113337">Teil 1</ext-link> <xref idref="R2215634-1">1</xref> physikalischen Grundlagen vorgestellt wurden, werden hier praktische Aspekte für den Anwender erläutert, unabhängig vom verwendeten Gerätetyp oder Hersteller. Grundsätzliche Parameter und Einstellmöglichkeiten vorgestellt. Es wird...