A5055156038- Renal cell carcinoma treatment
- Renal and related cancers
- Hereditary Neurological Disorders
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Knee injuries and reconstruction techniques
- Genetic Neurodegenerative Diseases
- Cancer Genomics and Diagnostics
- Muscle Physiology and Disorders
- Organ Donation and Transplantation
- Economic and Financial Impacts of Cancer
- Shoulder Injury and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Prostate Cancer Treatment and Research
- Dermatological and Skeletal Disorders
- Pediatric Urology and Nephrology Studies
- Muscle activation and electromyography studies
- Tendon Structure and Treatment
- Bone and Joint Diseases
- Cancer Treatment and Pharmacology
- Medical Imaging Techniques and Applications
- Erythrocyte Function and Pathophysiology
- Global Cancer Incidence and Screening
- Sports injuries and prevention
- Total Knee Arthroplasty Outcomes
Aix-Marseille Université
2019-2025
Centre de Résonance Magnétique Biologique et Médicale
2019-2025
Hôpital Saint Joseph
2023-2025
Hôpital Paris Saint-Joseph
2024-2025
Centre National de la Recherche Scientifique
2019-2025
Laboratoire d’Informatique et Systèmes
2024
Inserm
2024
Hôpital Privé Jacques Cartier
2024
Hôpital Européen Georges-Pompidou
2016
Barts Health NHS Trust
2016
<h3>Importance</h3> The role of cytoreductive nephrectomy in patients with metastatic renal cancer the era targeted therapy is uncertain. <h3>Objective</h3> To establish safety and efficacy upfront pazopanib prior to previously untreated clear cell cancer. <h3>Design, Setting, Participants</h3> Single-arm phase 2 study 104 recruited between June 2008 October 2012 at treatment centers access services. minimum follow-up was 30 months. <h3>Interventions</h3> Patients received 12 14 weeks...
Intramuscular fat fraction (FF) assessed using quantitative MRI (qMRI) has emerged as one of the few responsive outcome measures in CMT1A suitable for future clinical trials. This study aimed to identify relevance multiple qMRI biomarkers tracking longitudinal changes and assess correlations between metrics parameters.
Purpose To propose a novel segmentation framework that is dedicated to the follow‐up of fat infiltration in individual muscles patients with neuromuscular disorders. Methods We designed semi‐automatic pipeline leg MR images based on automatic propagation through nonlinear registrations initial delineation minimal number slices. This approach has been validated for from MRI data sets, acquired over 10‐month period, thighs and legs 10 muscular dystrophy. The robustness was evaluated using...
Deep learning methods have been shown to be useful for segmentation of lower limb muscle MRIs healthy subjects but, not sufficiently evaluated on neuromuscular disease (NDM) patients.Evaluate the influence fat infiltration convolutional neural network (CNN) from NMD patients.Retrospective study.Data were collected a hospital database 67 patients with NMDs and 14 controls (age: 53 ± 17 years, sex: 48 M, 33 F). Ten individual muscles segmented thigh six calf (20 slices, 200 cm section).A 1.5...
442 Background: In the U.S., racial disparities in renal cell carcinoma (RCC) are documented for common histologies, highlighting differences incidence and outcomes between Black non-Black patients. Such underexplored European populations, especially across a broader histology spectrum within universal healthcare system. We aim to investigate RCC histologies their among patients France. Methods: conducted retrospective cohort study utilizing UroCCR database, spanning from March 1957 May...
Intramuscular fat fraction (FF), assessed with quantitative MRI (qMRI), has emerged as one of the few responsive outcome measures in CMT1A patients. The main limitation for its use future therapeutic trials is time required manual segmentation individual muscles. This study aimed to evaluate accuracy and responsiveness a fully automatic artificial intelligence (AI)-based pipeline assess disease progression cohort patients over 1 year.
ABSTRACT Introduction Hereditary transthyretin amyloid polyneuropathy ( ATTRv ‐ PN ) is a rare and progressive neurodegenerative disorder characterized by axonal neuropathy deposits. Early detection of disease onset progression crucial for timely therapeutic intervention. Quantitative MRI qMRI can be used to measure potential biomarkers. Intraepineurial fat fraction ieFF may reflect lipid droplets in deposits as described histological studies or the replacement nerve fiber loss with...
Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a rare genetic disease with autosomal-dominant inheritance. In this study, we aimed to quantify fatty infiltration (fat fraction [FF]) and magnetization transfer ratio (MTR) in individual muscles of patients symptomatic asymptomatic TTR-FAP using magnetic resonance imaging. Secondarily, assess correlations clinical electrophysiological variables.A total 39 confirmed mutation the TTR gene (25 14 asymptomatic) healthy volunteers were...
Data regarding open conversion (OC) during minimally invasive surgery (MIS) for renal tumors are reported from big databases, without precise description of the reason and management OC. The objective this study was to describe rate, reasons, perioperative outcomes OC in a cohort patients who underwent MIS tumor initially. secondary find factors associated with Between 2008 2022, 8566 included UroCCR project prospective database (NCT03293563), laparoscopic or robot-assisted partial (MIPN)...
Intramuscular fat fraction (FF), assessed using quantitative MRI (qMRI), has emerged as a promising biomarker for hereditary transthyretin amyloidosis (ATTRv) patients. Currently, the main drawbacks to its use in future therapeutic trials are sensitivity change over short period of time and time-consuming manual segmentation step extract data. This pilot study aimed demonstrate suitability an Artificial Intelligence-based (AI) technique assess disease progression real-life cohort ATTRv...
Hydroxyurea (HU) is commonly used as a treatment for patients with sickle cell disease (SCD) to enhance fetal hemoglobin production. This increased production expected reduce anemia (which depresses oxygen transport) and abnormal Hb content alleviating clinical symptoms such vaso-occlusive crisis acute chest syndrome. The effects of HU on skeletal muscle bioenergetics in vivo are still unknown. Due the beneficial upon delivery, improved energetics function response have been hypothesized....
Knee osteoarthritis-related pain limits physical function and leads to functional disability. Physical activity is one of the central recommendations for management knee osteoarthritis. Although concentric muscle activities are often preferred eccentric ones, corresponding rationale remains controversial.To explore effect a 6-week exercise program on function, pain, performance in patients with symptomatic osteoarthritis.Patients osteoarthritis were included prospective EX-ART project...