A5037951357- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Dark Matter and Cosmic Phenomena
- Neutrino Physics Research
- MicroRNA in disease regulation
- Computational Physics and Python Applications
- Particle Detector Development and Performance
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Black Holes and Theoretical Physics
- Virus-based gene therapy research
- Atomic and Subatomic Physics Research
- Mesoporous Materials and Catalysis
- Medical Imaging Techniques and Applications
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer-related gene regulation
- Particle Accelerators and Free-Electron Lasers
- Advanced Nanomaterials in Catalysis
University of Chinese Academy of Sciences
2022-2025
Soochow University
2016-2025
First Affiliated Hospital of Soochow University
2016-2025
Institute of High Energy Physics
2015-2025
Sydney Dental Hospital
2024-2025
The University of Sydney
2024-2025
Northeast Forestry University
2025
Chinese Academy of Sciences
2015-2025
Nanjing Drum Tower Hospital
2023-2025
South China Sea Institute Of Oceanology
2025
Mesoporous carbon hollow spheres (MCHS) have wide applications, including catalysis, absorption, and energy storage/conversion. Herein, we report a one-pot, surfactant-free synthesis of MCHS using three molecules: resorcinol, formaldehyde, tetrapropyl orthosilicate. The co-condensation process between the in situ generated silica primary particles polymer oligomers is regulated, leading to monodispersed with adjustable pore sizes from micropores 13.9 nm. resultant shows excellent performance...
Nature's creations with spiky topological features typically exhibit intriguing surface adhesive properties. From micrometer-sized pollen grains that can easily stick to hairy insects for pollination nanoscale virus particles are highly infectious toward host cells, multivalent interactions formed taking advantage of rough surfaces. Herein, this nature-inspired concept is employed develop novel drug delivery nanocarriers antimicrobial applications. A facile new approach developed fabricate...
Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic progressive inflammatory joint diseases that affect a large population worldwide. Intra-articular administration of various therapeutics is applied to alleviate pain, prevent further progression, promote cartilage regeneration bone remodeling in both OA RA. However, the effectiveness intra-articular injection with traditional drugs uncertain controversial due issues such as rapid drug clearance barrier afforded by dense structure...
Promoting innate immunity through pyroptosis induction or the cyclic GMP-AMP synthase-stimulator of interferon gene (cGAS-STING) pathway activation has emerged as a potent approach to counteract immunosuppressive tumor microenvironment and elicit systemic antitumor immunity. However, current inducers STING agonists often suffer from limitations including instability, unpredictable side effects, inadequate intracellular expression gasdermin STING. Here, tumor-specific nanotheranostic platform...
Abstract Osteoarthritis (OA) is a chronic joint disease characterized by synovitis and cartilage destruction. The severity of OA highly associated with the imbalance between M1 M2 synovial macrophages. In this study, novel strategy designed to modulate macrophage polarization reducing intracellular reactive oxygen species (ROS) levels regulating mitochondrial function. A ROS‐responsive polymer synthesized self‐assemble astaxanthin autophagy activator rapamycin form nanoparticles (NP@Poly...
A new type of monodispersed mesoporous silica nanoparticles with a core–cone structure (MSN‐CC) has been synthesized. The large cone‐shaped pores are formed by lamellae closely packed encircling spherical core, showing similar to the flower dahlia . MSN‐CC pore size 45 nm and high volume 2.59 cm 3 g −1 demonstrates loading capacity proteins successfully delivers active β‐galactosidase into cells, their potential as efficient nanocarriers for cellular delivery molecular weights.
Transdermal delivery of water-insoluble drugs via hydrogel-based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that fabricated from naturally derived polymer conjugates gelatin methacryloyl and β-cyclodextrin (GelMA-β-CD) reported. When curcumin, an unstable anticancer drug, loaded as model its stability solubility are improved due to the formation...
Asymmetric mesoporous silica nanoparticles (MSNs) with controllable head-tail structures have been successfully synthesized. The head particle type is tunable (solid or porous), and the tail has dendritic large pores. length coverage on particles are adjustable. Compared to spherical a solid structure (Stöber spheres) large-pore symmetrical MSNs fully covered tails, asymmetrical (HTMSNs) show superior hemocompatibility due reduced membrane deformation of red blood cells decreased level...
The abuse of antibiotics has led to the emergence antibiotic resistant bacteria and high threats human health. search for safe effective alternatives traditional is growing worldwide. In this article, we report synthesis large pore dendritic mesoporous silica nanoparticles (DMSNs) with controllable particle sizes investigate relationship between size DMSNs their antibacterial enzyme delivery performance. choice dual-functional perfluorocarbon anions both low surface tension interaction...
In this work, the role that manganese plays in determining structure and performance of sintered biodegradable porous Fe–Mn alloys is described. Powder metallurgy processing was employed to produce a series Fe-xMn (x = 20, 30, 35 wt %) suitable for bone scaffold applications. Increasing content increased porosity volume influenced ensuing properties metal. The Fe-35Mn alloy possessed optimum orthopedic application. X-ray diffraction analysis magnetic characterization confirmed predominance...
Exosomes in the tumor microenvironment (TME) facilitate progression by enabling inter-cellular communication. Tumor cell-derived exosomes can polarize tumor-associated macrophages (TAMs) to an immunosuppressive M2 phenotype. The aim of this study was determine role exosomal circFARSA non-small cell lung cancer (NSCLC) and elucidate underlying mechanisms. In situ expression NSCLC tissues analyzed using qRT-PCR. vitro migration cells evaluated a transwell assay or through indirect co-culture...
Abstract Sentinel lymph node imaging and biopsy is important to clinical assessment of cancer metastasis, novel non-radioactive lymphographic tracers have been actively pursued over the years. Here, we develop gold molecular clusters (Au 25 ) functionalized by phosphorylcholine (PC) ligands for NIR-II (1000–3000 nm) fluorescence draining nodes in 4T1 murine breast CT26 colon tumor mouse models. The Au-phosphorylcholine (Au-PC) probes exhibit ‘super-stealth’ behavior with little interactions...