Abstract Background Exercise promotes brain health and improves cognitive functioning in the elderly, while 40-Hz light flickering through visual cortex reduces amyloid beta (Aβ) by stabilizing gamma oscillation. We examined whether exercise was associated with hippocampus-mediated improvement 3xTg-Alzheimer’s disease (3xTg-AD) murine model following exposure to exercise. Methods subjected 12-month-old 3xTg-AD mice for 3 months investigate spatial learning, memory, long-term Aβ levels, tau...

Obesity, caused by a high-fat diet (HFD), leads to insulin resistance, which is precursor of diabetes and risk factor for impaired cognitive function, dementia, brain diseases, such as Alzheimer’s disease. Physical exercise has positive effects on obesity functions. We investigated whether the decline in function HFD could be improved through examining signaling pathways neuroplasticity hippocampus. Four-week-old C57BL/6 male mice were fed or regular 20 weeks, followed 12 weeks treadmill...

Thrombotic stroke is a type of ischemic characterized by motor dysfunction and memory impairments. In the present study, effect treadmill exercise on function short-term was evaluated in relation with synaptic plasticity mice photothrombotic stroke.Photothrombotic induced cortical vascular occlusion. The groups performed running motorized for 28 days. Motor determined using rota-rod test foot fault test. Step-through avoidance task conducted to evaluate memory. Immunohistochemistry...

Exercising in a 40-Hz light flicker environment was more effective than exercise or alone. This synergistic effect may prevent cognitive dysfunction by inhibiting Aβ, tau pathway, and neuroinflammation enhancing neuroplasticity mitochondrial functions the hippocampus during early Alzheimer’s disease.

Purpose Neurogenic lower urinary tract dysfunction (NLUTD) is a possible consequence of several neurological disorders. NLUTD may produce debilitating symptoms and serious complications, such as chronic renal failure, recurrent infections. Many animal studies have focused on models cerebral ischemia. In the present study, we investigated effects treadmill exercise memory function its relation to cell proliferation apoptosis in hippocampus, following transient global ischemia gerbils. Methods...

Physical exercise is one of the most effective methods for managing obesity, and exerts positive effects on various brain functions. Excessive weight gain known to be related impairment cognitive function. High-fat diet-induced obesity impairs hippocampal neuroplasticity, which impedes function, such as learning ability memory In this study, we investigated effect treadmill function in relation with neuroplasticity using high-fat obese mice. After was induced by a 20-week (60%) diet,...

Social isolation during adolescence is associated with anxiety, depres-sion, and memory impairment. Exercise has been reported as a positive effect on brain function, especially hippocampus. The present study ex-amined the of swimming exercise apoptosis, cell proliferation, serotonin expression in social rats stage. started at postnatal day 21 continued for 6 weeks. group were forced to swim 60 min once daily days per week consecutive showed depression, short-term facilitated apoptosis...

Attention-deficit hyperactivity disorder (ADHD) is a neurobehavioral characterized by inattention, and impulsivity. In the present study, we investigated effects of swimming exercise on symptoms ADHD in correlation with expression levels dopamine D2 receptor. Adult male spontaneous hypertensive rats (SHRs) were used as animal models Wistar-Kyoto controls. The activity, impulsivity non-aggressive aggressive behaviors measured. short-term memory was assessed using an open-field test. social...

Parkinson disease is one of the common brain diseases caused by dopaminergic neuronal loss in substantia nigra and fiber striatum. In present study, effects treadmill exercise on motor performance, neurons fibers, α-synuclein expression nigrostriatum were evaluated using rotenone-induced rats. For induction rats, 3-mg/kg rotenone was injected, once a day for 14 consecutive days. Treadmill running conducted 30 min during Rota-rod test balance coordination immunohistochemistry tyrosine...

Obesity is characterized by the induction of skeletal muscle remodeling and mitochondria-mediated apoptosis. Exercise has been reported as a positive regulator However, effects exercise on apoptosis in obese muscles have not clearly elucidated. Four-week-old C57BL/6 mice were randomly assigned into four groups: control (CON), plus (CON + EX), high-fat diet (HFD), HFD groups (HFD EX). After obesity was induced 20 weeks 60% feeding, treadmill performed for 12 weeks. ameliorated obesity-induced...

[Purpose] This study performed to investigate the effect of elastic band exercise program on posture subjects with rounded shoulder and forward head posture. [Subjects Methods] The body length, angle, craniovertebral cranial rotation angle participants (n=12) were measured before after program. Furthermore, thicknesses pectoralis major, rhomboid upper trapezius using an ultrasonographic imaging device. exercises was conducted bands, 15 repetitions per set 3 sets in total. [Results] length...

Rotenone is the most widely used neurotoxin for making Parkinson disease (PD) animal model. The neurodegenerative disorder PD shows symptoms, such as slowness of movements, tremor at resting, rigidity, disturbance gait, and instability posture. We investigated whether treadmill running improves motor ability using rotenone-caused rats. effect on was also assessed in relation with apoptosis cerebellar Purkinje cells.Treadmill applied to rats exercise groups 30 minutes once a day 4 weeks,...

Autism is a neurodevelopmental disorder and this shows impairment in reciprocal social interactions, deficits communication, restrictive repetitive patterns of behaviors interests. The effect music on short-term memory the view cell proliferation hippocampus was evaluated using valproic acid-induced autistic rat pups. Animal model autism made by subcutaneous injection 400-mg/kg acid into pups postnatal day 14. music-applied groups were exposed to 65-dB comfortable classic for 1 hr once day,...

Alzheimer’s disease is the most common neurodegenerative brain causing dementia. It characterized by slow onset and gradual worsening of memory other cognitive functions. Recently, parabiosis infusion plasma from young mice have been proposed to positive effects in aging disease. Therefore, this study examined whether exercised improved functions related hippocampus a 3xTg-Alzheimer’s (AD) model. We collected that had for 3 months injected 100 µL into tail vein 12-month-old 3xTg-AD 10 times...

The effects of maternal exercise on hippocampal neurogenesis, synaptic protein expression, and gut microbiome composition in the offspring older females were investigated. Male from female C57BL/6 mice divided into four groups: young group (CON), exercised group, advanced-age (AMA), (AMA+EX). received 8 weeks treadmill training before during pregnancy. assessed at 4 age. Hippocampal neurogenesis was by 5-bromo-2’-deoxyuridine/neuronal double immunofluorescence staining. Expression...

Attention deficit/hyperactivity disorder (ADHD) is a neurobehavioral of cognition. We investigated the effects treadmill exercise on Purkinje cell and astrocytic reaction in cerebellum ADHD rat. Adult male spontaneously hypertensive rats (SHR) Wistar-Kyoto (WKYR) weighing 210± 10 g were used. The animals randomly divided into four groups (n= 15): control group, methylphenidate (MPH)-treated group. MPH-treated group as positive received 1 mg/kg MPH orally once day for 28 consecutive days....

The olfactory bulbectomy (OBX) is a well-known method inducing animal model of depression. Depression associated with dysfunction serotonin (5-hydroxytryptamine, 5-HT) system. In the present study, antidepressive effect treadmill exercise was investigated using bulbectomized rats. After bilateral bulbectomy, rats in groups were subjected to run on for 30 min once day during 28 days. Increased immobility time and decreased fast forced swim test observed Sucrose preference sucrose activity...