A5058876690- Alzheimer's disease research and treatments
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Cellular transport and secretion
MRC Laboratory of Molecular Biology
2023-2025
Medical Research Council
2023-2024
Abstract The abnormal assembly of tau protein in neurons is a pathological hallmark multiple neurodegenerative diseases, including Alzheimer’s disease (AD). Assembled associates with extracellular vesicles (EVs) the central nervous system individuals AD, which linked to its clearance and prion-like propagation. However, identities assembled species EVs, as well how they associate, are not known. Here, we combined quantitative mass spectrometry, cryo-electron tomography single-particle...
SUMMARY The abnormal assembly of tau protein in neurons is the pathological hallmark multiple neurodegenerative diseases, including Alzheimer’s disease (AD). In addition, assembled associates with extracellular vesicles (EVs) central nervous system patients AD, which linked to its clearance and prion-like propagation between neurons. However, identities species EVs, as well how they associate, are not known. Here, we combined quantitative mass spectrometry, cryo-electron tomography...
Abstract Extracellular release and cellular uptake of pathogenic forms the microtubule-associated protein tau contribute to pathogenesis several neurodegenerative diseases, including Alzheimer’s disease. Defining mechanisms pathways for entry human neurons is essential understanding tauopathy rational design disease-modifying therapeutics. Whole genome CRISPR loss-of-function screens in iPSC-derived excitatory neurons, major neuronal cell type affected these enabled delineation different...