A5014260916- Material Dynamics and Properties
- Drug Solubulity and Delivery Systems
- Biological Research and Disease Studies
- Glass properties and applications
- Crystallization and Solubility Studies
- Advanced Drug Delivery Systems
- Thermodynamic properties of mixtures
- Marine Bivalve and Aquaculture Studies
- Synthesis of heterocyclic compounds
- Polymer crystallization and properties
- Fish Biology and Ecology Studies
- Ionic liquids properties and applications
- Invertebrate Immune Response Mechanisms
- Aquaculture Nutrition and Growth
- Phase Equilibria and Thermodynamics
- Advancements in Transdermal Drug Delivery
- Identification and Quantification in Food
- Synthesis and Catalytic Reactions
- Metallic Glasses and Amorphous Alloys
- Freezing and Crystallization Processes
- Connexins and lens biology
- Diverse Scientific Research Studies
- Higher Education and Teaching Methods
- Healthcare and Venom Research
- Synthesis and Reactivity of Sulfur-Containing Compounds
University of Wisconsin–Madison
2015-2019
AbbVie (United States)
2019
Fujian Normal University
2006-2011
Deutsch Amerikanisches Institut Saarland
2003-2011
Ann Arbor Center for Independent Living
1997
Surface-grating decay has been measured for three organic glasses with extensive hydrogen bonding: sorbitol, maltitol, and maltose. For 1000 nm wavelength gratings, the occurs by viscous flow in entire range of temperature studied, covering viscosity 10(5)-10(11) Pa s, whereas under same conditions, mechanism transitions from to surface diffusion similar molecular sizes but no or limited bonding. These results indicate that bonding slows down glasses. This effect arises because molecules can...
Molecular liquids can develop a fast mode of crystal growth ("GC growth") near the glass transition temperature. This phenomenon remains imperfectly understood with several explanations proposed. We report that GC in o-terphenyl conserves overall volume, despite 5% higher density crystal, and produces fine grains same unit cell as normally grown crystals. These results indicate continuously creates voids free surfaces, possibly by fracture. aspect has not been considered previous treatments...
Recent work has shown that diffusion and crystal growth can be much faster on the surface of molecular glasses than in interior enhancement effect varies with size intermolecular hydrogen bonds (HBs). In a related phenomenon, some molecules form highly stable when vapor-deposited, while others (notably those forming extensive HBs) do not. Here we examine all available data these phenomena for quantitative structure-property relations. For systems no HBs, coefficient Ds decreases increasing d...
The incorporation of counterions into amorphous solid dispersions (ASDs) has been proven to be effective for improving the dissolution rates ionizable drugs in ASDs. In this work, effect buffer pH and concentration on rate indomethacin-copovidone 40:60 (IMC-PVPVA, w/w) ASD with or without incorporated sodium hydroxide (NaOH) was studied by surface area-normalized provide further mechanistic understanding phenomenon. Buffer from 4.7 7.2 20 100 mM at 5.5 were investigated. As decreased, IMC...
Surface grating decay measurements have been performed on three closely related molecular glasses to study the effect of intermolecular hydrogen bonds surface diffusion. The molecules are derivatives bis(3,5-dimethyl-phenylamino)-1,3,5-triazine and differ only in functional group R at 2-position, with being C2H5, OCH3, NHCH3, referred as "Et", "OMe", "NHMe", respectively. Of molecules, NHMe forms more extensive than Et OMe was found slower For OMe, diffusion is so fast that it replaces...
The incorporation of a counterion into an amorphous solid dispersion (ASD) has been proven to be attractive strategy improve the drug dissolution rate. In this work, generality enhancing rates free acid ASDs by incorporating sodium hydroxide (NaOH) was studied surface-area-normalized dissolution. A set diverse molecules, two common polymer carriers (copovidone or PVPVA and hydroxypropyl methylcellulose acetate succinate HPMCAS), sample preparation methods (rotary evaporation spray drying)...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrophilic olefin heterocyclization in organic synthesis. Highly stereoselective synthesis of trans 3,5-disubstituted pyrrolidin-2-ones by iodolactamization via homoallylic asymmetric inductionHiroki Takahata, Tamotsu Takamatsu, Yinshan Chen, Naoki Ohkubo, Takao Yamazaki, Takefumi Momose, and Tadamasa DateCite this: J. Org. Chem. 1990, 55, 12, 3792–3797Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published...
Solubility enhancement has become a common requirement for formulation development to deliver poorly water soluble drugs. Amorphous solid dispersions (ASDs) and salt formation have been two successful strategies, yet there are opportunities further development. For ASDs, drug-polymer phase separation may occur at high drug loadings during dissolution, limiting the increase of in ASD formulations. formation, form with crystallinity sufficient solid-state stability is required dosage This work...
Molecular glasses indomethacin and ortho-terphenyl were formed fractured by cooling a liquid on less thermally expansive substrate. In-plane tension was created the mismatch of thermal expansion coefficients accumulated to cause catastrophic network fracture. Differential scanning calorimetry used characterize process. The heat fracture exceeds 10 times strain energy released, matches excess enthalpy stored an elastic film that is cooled under lateral constraint. constrained has smaller...