A5101747699- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- Nutritional Studies and Diet
- Force Microscopy Techniques and Applications
- Mechanical and Optical Resonators
- Blood Pressure and Hypertension Studies
- Bone health and osteoporosis research
- Cancer-related Molecular Pathways
- Birth, Development, and Health
- Cardiomyopathy and Myosin Studies
- Vitamin D Research Studies
- Genetics, Aging, and Longevity in Model Organisms
- Obesity, Physical Activity, Diet
- COVID-19 diagnosis using AI
- Trace Elements in Health
- Cryospheric studies and observations
- Diet, Metabolism, and Disease
- Enhanced Recovery After Surgery
- CAR-T cell therapy research
- Nausea and vomiting management
- Reproductive Biology and Fertility
- Educational Technology and Pedagogy
- Calpain Protease Function and Regulation
- Nutrition, Genetics, and Disease
- Congenital heart defects research
Civil Aviation University of China
2025
Air Force Medical University
2012-2024
Zhongda Hospital Southeast University
2024
Xijing Hospital
2023-2024
Tang Hospital
2024
Yuxi Normal University
2018-2023
AbbVie (United States)
2023
Northwest A&F University
2023
Macau University of Science and Technology
2022
Tongji University
2021
The metabolic consequences of obesity are well-documented in Western populations. However, limited data available on the association between body mass index (BMI) and cardiovascular risk factors developing countries. authors therefore examined BMI a very lean population China. A total 2,542 subjects aged 20–70 years from rural area Anqing, China, participated cross-sectional survey, 1,610 provided blood samples 1993. Mean (kg/m2) was 20.7 for men 20.9 women. After adjustment age, sex,...
We used targeted gene inactivation to analyze the function of a Caenorhabditis elegans POU gene, ceh-18, and dissect its functional domains in vivo. In ceh-18 mutants, oocytes exhibit an incompletely penetrant failure arrest diakinesis meiotic prophase I instead undergo multiple rounds DNA replication without cytokinesis. is expressed gonadal sheath cells that signal oocyte, but not oocyte. This suggests affects, directly or indirectly, cell causes maintain arrest. also participates...
ObjectiveHuman neural precursor cell-expressed developmentally down-regulated 4 like (Nedd4L), a ubiquitin protein ligase, is expressed by various cancer cells and might have an oncogenic property. Its expression pattern in glioma tissues unknown. Therefore, the aim of this study was to investigate whether Nedd4L present evaluate correlation with progression prognosis disease.
<title>Abstract</title> To enhance the comprehensiveness and systematicness of human factor analysis in aircraft accidents on apron, this paper integrates environmental adaptability SHEL model, failure traceability mechanism HFACS accident chain tracking advantage TER model to construct H-S-TER composite model. This through ternary structure trigger factors, unsafe behaviors, result events, realizes multi-level deconstruction human-caused factors from organizational management operation...
<h3>Objective:</h3> To investigate the association of adiposity measures with blood pressure (BP) in Chinese children and adolescents. <h3>Design:</h3> A cross-sectional study. <h3>Participants:</h3> 1330 boys 1170 girls aged 6–18 years from a rural population-based cohort twins studied Anhui, China, 1998–2000. <h3>Outcome measures:</h3> Adiposity included body mass index (BMI), total fat trunk assessed by dual-energy <i>x</i>-ray absorptiometry. BMI was divided into (FMI) lean (LMI)...
Purpose: To compare clinical outcomes after correction of moderate to high astigmatism through small-incision lenticule extraction (SMILE) with and without limbal marking. Setting: Tianjin Eye Hospital, Tianjin, China. Design: Prospective randomized comparative case series. Methods: This prospective control study included 240 unilateral eyes patients who underwent SMILE more than 0.75 diopters (D). The were randomly assigned a marked group (120 eyes) or an unmarked eyes). Manifest refraction...
Routine HIV testing is increasingly recommended in resource-limited settings. Our objective was to evaluate factors associated with a new diagnosis of infection routine programme South Africa.We established an out-patient department Durban, Africa. All registered adults were offered rapid test; we surveyed sample tested patients.During the 12-week study, 1414 accepted testing. Of those, 463 (32.7%) HIV-infected. Seven hundred and twenty (50.9%) surveyed. Compared married women, unmarried men...
Aberrant methylation of the breast cancer susceptibility gene 1 (BRCA1) promoter is a mechanism for its functional inactivation. It may potentially be used as prognostic marker in studies patients with and plays an important role tumorigenesis. Numerous have suggested that BRCA1 associated prognosis cancer. However, different ethnicities remains ambiguous. The present meta-analysis was performed to adjust augment previously published study, which estimated correlations between clinical...
The mutation p53 N236S (p53S) has been identified as one of the recurrent mutations in human cancers by TCGA database. Our vitro data revealed oncogenic gain function p53S. To understand p53S vivo , we generated knock‐in mouse. S/S mice manifested highly invasive lymphomas and metastatic sarcomas with dramatically increased double minute chromosomes. survival curve, incidence tumors tumor spectrum is very similar to R172H mouse model. S/+ showed delayed onset tumorigenesis a high metastasis...
This study investigated blood pressure in 1,183 Chinese nuclear families (mother, father, and first two children) via a cross-sectional 1994-1997 survey. The mother's, the father's, sibling's pressures were each significantly independently related to second after adjustment for sex, age, height, weight, education, smoking, alcohol consumption. association was consistent across four age strata (6-10, 11-14, 15-19, > or = 20 years). rate of high systolic sibling lowest (2.3%) when both parents...
Missense mutations in the p53 coding gene cause loss and gain of function. We have identified a hotspot mutation, N236S , which results aggressive progression tumorigenesis knock‐in mouse model. To understand biological significance we performed Ch IP ‐on‐chip combined with microarray assay to profile regulated expression pattern. could classify mutant function into six categories. Among these, reveal new aspect function, enhancement wild‐type has not been reported previously. also show...
With the invention of scanning tunneling microscopy (STM) in early 1980s by Binnig and Rohrer, real-space access to structures on atomic scale became possible. For STM, four things are great important: preparation tips, approach mechanism, vibration isolation piezo device. In this paper, we'll try describe main method prepare result our experiments tips. Then introduce methods make a fine mechanism present new method. At last there will be brief introduction different mechanical design that...
Abstract The novel coronavirus disease 2019 (COVID-19) has emerged as an enormous challenge facing China today. Preventive Medicine physicians and Artificial Intelligence (AI) researchers try to improve the ability early automatic warning of infections, promote epidemic prevention, reduce medical costs using deep learning methods. In this work, we build extensive database chest computed tomography (CT) scans with image data from domestic international open-source datasets. Swin Transformer...
With the prevalence of quantum theory, many physicists have focused on Bose-Einstein condensation (BEC) because it reveals behavior macroscopically. This article discusses briefly discovery BEC and difficulties to achieve BEC. After that, general procedures are introduced while mechanism important techniques accomplish each procedure is illustrated, such as laser cooling, trapping, evaporative cooling. Besides, unique physical properties in this article. Finally, possible application field...
<h3>Background</h3> Risankizumab (RZB) is a selective interleukin (IL) 23 p19 subunit monoclonal antibody that inhibits IL-23. RZB 150 mg has shown greater improvements in key clinical domains such as skin, joints, enthesitis, and dactylitis compared with placebo (PBO) patients active psoriatic arthritis (PsA) the global phase 3 trials KEEPsAKE 1 (NCT03675308) 2 (NCT03671148) <sup>[1,2]</sup>. <h3>Objectives</h3> To elucidate mode of action PsA by assessing dynamics circulating protein...
The protection and restoration of existing buildings requires accurate acquisition the characteristics building facade. complex, diverse, irregular distribution facade components ethnic minorities have led to a huge workload field research, surveying, mapping, calculation, it is more difficult extract its accurately. This study proposes visual model based on Swin Transformer applies graphic recognition elevations. combines advantages migration learning method deep neural network technology...
To analyze the relationship between genotype and clinical phenotype of MYH7-R453C mutation in five Chinese hypertrophic cardiomyopathy (HCM) families.
In this paper, different methods to make piezo design, vibration isolation and approach mechanism were described. The device research on also introduced. the last part of work, new design experimental result presented. method is called gear-based mechanism. It consists a series gears can reduce produced by hands during scanning process. shows that work very well. STM system in various conditions with simple assembly.