A5076754993- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Endoplasmic Reticulum Stress and Disease
- Cholesterol and Lipid Metabolism
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
Shanghai Sixth People's Hospital
2021-2023
Shanghai Jiao Tong University
2021-2023
Complex immune contexture leads to resistance immunotherapy in hepatocellular carcinoma (HCC), and the need for new potential biomarkers of HCC is urgent. Histone chaperones are vital determinants gene expression genome stability that regulate tumor development. This study aimed investigate effect histone on immunity HCC. Bioinformatics analyses were initially performed using The Cancer Genome Atlas (TCGA) database, validated Gene Expression Omnibus (GEO) database International Consortium...
Inhibition of hepatic lipogenesis is widely regarded as an effective treatment for metabolic-associated fatty liver disease (MAFLD), although numerous related drugs have failed to reach clinical application. The goal this study identify a novel small compound that can effectively treat MAFLD.Primary hepatocytes were first exposed palmitic acid and oleic acid, then treated with compounds prior high through screening cellular lipid content. efficacy these was measured by Nile Red staining...