A5087019976- Magnesium Alloys: Properties and Applications
- Bone Tissue Engineering Materials
- Silk-based biomaterials and applications
- Aluminum Alloys Composites Properties
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Hydrogen Storage and Materials
- Titanium Alloys Microstructure and Properties
- Reconstructive Surgery and Microvascular Techniques
- Corrosion Behavior and Inhibition
- Reconstructive Facial Surgery Techniques
- Surface Modification and Superhydrophobicity
- Antimicrobial Peptides and Activities
- Liver Disease and Transplantation
- Advanced Sensor and Energy Harvesting Materials
- Tendon Structure and Treatment
- Breast Implant and Reconstruction
- Oral microbiology and periodontitis research
- Esophageal and GI Pathology
- Orthopedic Infections and Treatments
- Dental Implant Techniques and Outcomes
- Abdominal vascular conditions and treatments
- Wound Healing and Treatments
- Bone fractures and treatments
- Organ Transplantation Techniques and Outcomes
RWTH Aachen University
2018-2025
Sankt-Antonius-Hospital Eschweiler
2024-2025
University Hospital Cologne
2020-2023
University of Cologne
2020-2023
University Medical Center Hamburg-Eppendorf
2015-2019
Universität Hamburg
2015-2019
Universitätsklinikum Aachen
2018
Magnesium is a highly promising candidate with respect to its future use as material for resorbable implants. When magnesium degrades, hydrogen gas released. High doses of emergence are reported impair osseointegration and may therefore lead fixation failure. The successful delay reduction the degradation rate by applying plasma electrolytic oxidation (PEO) post processing surface modification method alloy has recently been demonstrated. aim this study was thus compare behavior WE43-based...
ABSTRACT Biliary duct reconstruction is one of the most challenging parts liver transplantation and accounts for 40%–60% complications. While current stent‐based devices on market show promising results in reducing complications, they are manufactured from permanent synthetic materials require a second reintervention their removal. This exposes patients to other potential complications increases healthcare costs. study develops fabrication technique produce bioabsorbable biliary stent based...
Silk fibroin is a biomaterial with multiple beneficial properties for use in regenerative medicine and tissue engineering. When dissolving processing the reconstituted silk solution by electrospinning, arrangement size of fibers can be manifold varied according fiber diameters reduced to nanometer range. Such nonwovens show high porosity as well potential biocompatibility. Usually, electrospinning most biomaterials demands application additives, which enable stable adjusting viscosity, are...
Additively manufactured scaffolds offer significant potential for treating bone defects, owing to their porous, customizable architecture and functionalization capabilities. Although various biomaterials have been investigated, metals - the most successful orthopedic material yet yield satisfactory results. Conventional bio-inert metals, such as titanium (Ti) its alloys, are widely used fixation devices reconstructive implants, but non-bioresorbable nature mechanical property mismatch with...
Bioabsorbable magnesium implants for orthopedic fixation of bone have recently become available different fields indication. While general questions biocompatibility been answered, tailoring suitable degradation kinetics specific applications as well long-term tissue integration remain the focus current research. The aim this study was evaluation behavior and osseointegration Mg-Ca-Zn (ZX00MEO) based with plasma-electrolytic oxidation (PEO) surface modification (ZX00MEO-PEO) in comparison to...
Commercial purity titanium (cp-Ti) is considered for replacing Ti64 as an implant material in various applications, due to the potential toxicity associated with release of Al and V ions. However, mechanical properties cp-Ti, particularly fatigue resistance, are inadequate this purpose. In study, cp-Ti grade 4 rods were processed using a combination equal channel angular pressing rotary swaging (ECAP/RS). Tensile tests conducted, along detailed microscopy evaluation corrosion resistance...
Injectable hydrogels with self-healing properties, tissue adhesion, biocompatibility, and cancer therapeutic capabilities offer a promising solution for addressing bone loss residual tumor cells following surgical resection of osteosarcoma. In this study, injectable adhesive hybrid were developed using natural silk-derived proteins, silk fibroin (SF), sericin (SS). The was surface functionalized dopamine (DOPA) forming SSDOPA, while the enzymatically oxidized (forming SFO) to introduce...
Large segmental mandible bone defects still represent a challenge for endogenous regeneration. Despite the bone's capacity to heal in many clinical situations, over critical size do not spontaneously. An emerging treatment of critically sized mandibular is implantation individually manufactured scaffolds consisting biodegradable magnesium alloys. Biomedical engineers faced developing scaffold structure that only provides sufficient stability, but also stimulates and promotes growth while...
Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial development these implants. To achieve implant success, an understanding cellular responses post-implantation, proper model selection, good study design are crucial. There several challenges reaching a...
Deep inferior epigastric artery flaps (DIEP) represent the gold standard of autologous breast reconstruction. Due to significant variations in vascular anatomy, preoperative perforator mapping (PM) is mandatory order ensure presence a sufficient within flap. In this regard, CT angiography (CTA) currently method choice. Therefore, we investigated value contrast-enhanced ultrasound (CEUS) techniques for PM comparison CTA. Patients underwent PM, utilizing both CTA and CEUS techniques....
SUMMARY Precise perforator mapping of the epifascial and subcutaneous course flaps, including precise detection skin point, is mandatory for successful preoperative flap design planning supramicrosurgery. We investigated effectiveness contrast-enhanced B-flow (BCEUS) imaging compared it with ultrasound, color Doppler ultrasound. Sixteen patients who received an individualized reconstruction were included in study. Preoperative includes following structures: subfascial pedicle, fascial...
Abstract Objectives The aim of this retrospective cohort study was to determine risk factors for osteosynthesis-associated infections (OAI) with subsequent necessity implant removal in oral and maxillofacial surgery. Materials methods A total 3937 records patients who received either orthognathic, trauma, or reconstructive jaw surgery from 2009 2021 were screened osteosynthetic material due infection. Treatment-intervals, volume applied material, respective surgical procedures also assessed....
In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from silkworm Bombyx mori. To date, dissolution process used in study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses absence toxic chemicals comparison other conventional techniques. Therefore, aim was determine influence different concentrations on output resulting membrane properties. Casted were thus characterized...
Organ shortage has led to the increasing utilization of livers retrieved from donors after circulatory death (DCD). These pre-damaged organs are susceptible further warm ischemia and exhibit minimal tolerance for cold storage. The aim was thus examine effects fibrinolysis combined with Venous Systemic Oxygen Persufflation (VSOP) on preservation DCD in vivo. Livers male Lewis rats were explanted 45 min ischemia, cold-stored 18 h, transplanted into a recipient animal. left untreated or...