A5022754834- RNA Research and Splicing
- Muscle Physiology and Disorders
- RNA modifications and cancer
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Neurogenetic and Muscular Disorders Research
- Endoplasmic Reticulum Stress and Disease
- Force Microscopy Techniques and Applications
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- Hemiptera Insect Studies
- Cancer-related molecular mechanisms research
- Muscle activation and electromyography studies
Cyprus Institute of Neurology and Genetics
2015-2022
University of York
2017-2020
Twist-1 is mostly expressed during development and has been previously shown to control myogenesis. Since its regulation in muscle not fully exploited, the aim of project was identify miRNAs which regulate Twist-1. miR-206, one most important myomiRs, identified as a possible candidate for mRNA. Luciferase assays transfections human foetal myoblasts showed that direct target miR-206 through this pathway cell differentiation promoted. We next investigated whether MyoD, major myogenic...
Muscular dystrophies are a group of disorders that cause progressive muscle weakness. There is an increasing interest for the development biomarkers these and specifically Duchene Dystrophy. Limited research however, has been performed on biomarkers' most rare muscular dystrophies, like Facioscapulohumeral Dystrophy, Limb-Girdle Dystrophy Myotonic type 2. Here, we aimed to identify novel serum-based miRNA through high-throughput next-generation RNA sequencing. We identified many miRNAs...
Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy, primarily characterized by muscle wasting and weakness. Many biomarkers already exist in rapidly developing biomarker research field that aim to improve patients' care. Limited work, however, has been performed on rare diseases, including DM1. We have previously shown specific microRNAs (miRNAs) can be used as potential for DM1 progression. In this report, we aimed identify novel serum-based through...
Twist-1 is mostly expressed during development and has been previously shown to control myogenesis. Because its regulation in muscle not fully exploited, the aim of this project was identify micro (mi)RNAs that regulate Twist-1. miR-206, one most important muscle-specific miRNAs (myomiRs), identified as a possible regulator mRNA. Luciferase assays transfections human foetal myoblasts showed direct target miR-206 through pathway cell differentiation promoted. We next investigated whether...
Muscular dystrophies are a group of rare and severe inherited disorders mainly affecting the muscle tissue. Duchene Dystrophy, Myotonic Dystrophy types 1 2, Limb Girdle Facioscapulohumeral some members this family disorders. In addition to current diagnostic tools, there is an increasing interest for development novel non-invasive biomarkers diagnosis monitoring these diseases. miRNAs small RNA molecules characterized by high stability in blood thus making them ideal biomarker candidates...