A5037078540- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Pharmacogenetics and Drug Metabolism
- Folate and B Vitamins Research
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Genetic Syndromes and Imprinting
- Genetic diversity and population structure
- Inflammatory mediators and NSAID effects
- Acute Lymphoblastic Leukemia research
- Congenital Heart Disease Studies
- Forensic and Genetic Research
- Diet, Metabolism, and Disease
- Reproductive System and Pregnancy
- Nutrition, Genetics, and Disease
- Prenatal Screening and Diagnostics
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Kruppel-like factors research
- Phytochemicals and Antioxidant Activities
- Genomics and Phylogenetic Studies
- Tuberculosis Research and Epidemiology
- Epigenetics and DNA Methylation
- Pregnancy and Medication Impact
- Acupuncture Treatment Research Studies
Instituto Politécnico Nacional
2016-2025
Ibero American University
2023-2025
PharmacoGenetics (China)
2023
Durango Institute of Technology
2012-2023
Centro de Investigación y Desarrollo
2011-2014
Institute for Social Security and Services for State Workers
2006-2008
National Institutes of Health
2003
Mexican Social Security Institute
2003
Abstract The genetic makeup of Indigenous populations inhabiting Mexico has been strongly influenced by geography and demographic history. Here, we perform a genome-wide analysis 716 newly genotyped individuals from 60 the 68 recognized ethnic groups in Mexico. We show that structure these is geography, our reconstructions suggest decline population size all tested last 15–30 generations. find evidence Aridoamerican Mesoamerican diverged roughly 4–9.9 ka, around time when sedentary farming...
Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was established to characterize interindividual and between population variations CYP2D6, CYP2C9, CYP2C19 drug metabolizing enzyme genotypes, were subsequently utilized catalog their "predicted metabolism phenotypes" across Native American Ibero populations. Importantly, we report this study, total 6060 healthy individuals from...
Obesity, type II diabetes, and hyperlipidaemia, which frequently coexist are strongly associated with oxidative stress, increase the risk of cardiovascular disease. An in carbohydrate intake, especially fructose, a high-fat diet both factors that contribute to development these metabolic disorders. In recent studies carried out diabetic rats, authors reported Ibervillea sonorae had hypoglycaemic activity; saponins monoglycerides present plant could be responsible for effects observed. study,...
Aim: Polymorphisms in CYP2D6 impact the interindividual and interethnic variability of drug efficiency; therefore, we determined allele distribution eight Amerindian groups from northwestern Mexico compared them with frequencies Mexican Mestizos. Materials & methods: A total 508 Amerindians were studied. Genotyping CYP2D6*5 multiplication alleles was performed by long-range PCR, while CYP2D6*2, *3, *4, *6, *10, *17, *29, *35, *41 copy number evaluated real-time PCR. Results: The most...
To evaluate the effects on anencephaly risk of interaction between maternal profile folate, vitamin B12 and homocysteine 677C→T polymorphism in gene encoding methylenetetrahydrofolate reductase (MTHFR).Case-control study paired (1:1) maternity clinic, date birth state residence. Cases were identified using Registry Mexican Neural Tube Defect Epidemiological Surveillance System. Case control mothers selected from same departments. All completed a structured questionnaire blood samples...
Objective: To examine expression profile of magnesium responsive genes (MRGs) in placentas normoevolutive and preeclamptic women. Methods: The profiles MRGs were determined (N = 26) 25) women by RT-qPCR. Results: Among all tested (9) only SLC41A1 (encoding for Na+/Mg2+ exchanger) was significantly overexpressed ∼54.2% (n 24) ∼9.5% 21) specimens. On average, sixfold the group. Presence confirmed Western blot analysis. Conclusion. is nearly 55% placentas. This may indicate a direct...
Introduction: Clozapine (CLZ) is the gold standard drug for treatment-refractory schizophrenia (TRS). However, approximately 30% of patients partially respond to CLZ, defining this subset with super refractory (SRS). Alterations in enzyme activity may affect CLZ responses; CYP3A4, CYP1A2 and CYP2C19 genes are primarily responsible metabolism. Objective: The aim study was assess if variants were associated TRS or SRS. Methods: CYP2C19*2 loss-of-function CYP2C19*17 gain-of-function...
The precise etiology of neural tube defects (NTDs) is not known. There some evidence that mutations in MTHFR gene provide susceptibility to NTDs populations; however, other studies have found this association. One the problems with previous they treat as a homogeneous group, when specific could different etiologies. We conducted case-control study specifically for anencephaly, based on Mexican Epidemiological Surveillance System Neural Tube Defects evaluate its association maternal 677C > T...
Congress of Pharmacogenetics and Personalized Medicine. Ethnicity, clinical implementation regulatory environment (MESTIFAR 2016 Quito) Quito, Ecuador, 19–21 May 2016. The Ibero-American Network Pharmacogenomics (RIBEF) was created in 2006 with the main aim promoting personalized medicine collaborative pharmacogenetics research Spanish- Portuguese-speaking countries America Iberian Peninsula. final goal this initiative inclusion Latin American populations that may benefit from drug therapy....
The Ibero-American Network of Pharmacogenetics and Pharmacogenomics (RIBEF) studies Latin American populations to benefit from the implementation personalized medicine. Since 2006, it has studied ethnicity apply pharmacogenetics knowledge in autochthonous America, considering ancestral meeting 'Pharmacogenetics: ethnicity, Treatment Health Populations' was held Mexico City, Mexico, presented relevance RIBEF collaboration with researchers governments Spain Autonomous Community Extremadura....
Objective: Complementary and alternative medicine, such as Traditional Chinese Medicine, represents an efficient therapeutic option for obesity control. It was previously reported that acupuncture catgut embedding therapy (ACET) with moxibustion reduces body weight reverts insulin resistance in obese women. This study aimed to evidence changes adipokines gene expression adipose tissue could explain the effects of ACET moxibustion. Design: Overweight/obese women were treated or sham...