A5075712334- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Autism Spectrum Disorder Research
- Regulation of Appetite and Obesity
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Biochemical Analysis and Sensing Techniques
- Genetics and Neurodevelopmental Disorders
- Thermal Regulation in Medicine
- Hormonal and reproductive studies
- Infant Development and Preterm Care
- Zebrafish Biomedical Research Applications
- Hormonal Regulation and Hypertension
- Nuclear Receptors and Signaling
- Epigenetics and DNA Methylation
- Meat and Animal Product Quality
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- Child Nutrition and Feeding Issues
Universitat de València
2016-2025
Universidad Cardenal Herrera CEU
2025
Universitat Jaume I
2020-2022
<title>Abstract</title> Rett Syndrome (RTT), a neurodevelopmental disorder predominantly affecting females, is characterised by evolving symptoms impacting motor and sensory domains. Herein, we present study of longitudinal analyses, from 2- to 6-month age, <italic>Mecp</italic>2 heterozygous (<italic>Mecp2</italic>-het) female mice comprehensively explore pain perception in RTT. Interestingly, found significant variability the timing progression symptom onset among...
<title>Abstract</title> Rett syndrome (RTT), a severe neurodevelopmental disorder primarily affecting girls, is commonly caused by <italic>MECP2</italic> loss-of-function mutations. Key symptoms include motor impairments, typical hand stereotypies and intellectual disability. Moreover, although not thoroughly studied, anxiety, heightened stress sensitivity, aberrant pain perception are also an important component of the RTT phenotype. Emerging evidence suggests that early-life (ELS) worsens...
The transitional zone between the ventral part of piriform cortex and anterior cortical nucleus amygdala, named cortex-amygdala transition (CxA), shows two differential features that allow its identification as a particular structure. First, it receives dense cholinergic dopaminergic innervations compared to adjacent second, projections from main accessory olfactory bulbs. In this work we have studied pattern afferent efferent CxA, which are mainly unknown, by using retrograde tracer...
Motherhood entails increased motivation for pups, which become strong reinforcers and guide maternal behaviours. This depends on steroids lactogens acting the brain of females during pregnancy postpartum. Since virgin female mice exposed to pups are nearly spontaneously maternal, specific roles endocrine pup-derived signals in induction remain unclear. work investigates dams mice, using a novel variant pup retrieval paradigm, motivated test. We also analyse role prolactin (PRL) stimuli...
The anterior cortical amygdaloid nucleus (ACo) is a chemosensory area of the amygdala that receives afferent projections from both main and accessory olfactory bulbs. role this structure unknown, partially due to lack knowledge its connectivity. In work, we describe pattern efferent ACo by using fluorogold biotinylated dextranamines as retrograde anterograde tracers, respectively. results show reciprocally connected with system basal forebrain, well basomedial amygdala. addition, it dense...
Abstract Virgin female laboratory mice readily express pup care when co-housed with dams and pups. However, pup-sensitized virgins fail to intruder-directed aggression on a single session of testing. To study whether repeated testing would affect the onset dynamics maternal or aggression, we tested their accompanying from postpartum day 4 6. Repeated led escalated towards male intruders in dams, but never developed aggression. In inhibition medial amygdala using DREADD (designer receptors...
Abstract Background Early-life stress can leave persistent epigenetic marks that may modulate vulnerability to psychiatric conditions later in life, including anxiety, depression and stress-related disorders. These are complex disorders with both environmental genetic influences contributing their etiology. Methyl-CpG Binding Protein 2 (MeCP2) has been attributed a key role the control of neuronal activity-dependent gene expression is master regulator experience-dependent programming....
Abstract During lactation, adult female mice display aggressive responses toward male intruders, triggered by male‐derived chemosensory signals. This behavior is not shown pup‐sensitized virgin females sharing pup care with dams. The genetic mechanisms underlying the switch from attraction to aggression are unknown. In this work, we investigate differential gene expression in lactating expressing maternal compared medial amygdala (Me), a key neural structure integrating and hormonal...
The olfactory system is a niche of continuous structural plasticity, holding postnatal proliferative neurogenesis in the bulbs and population immature neurons piriform cortex. These cortex are generated during embryonic development, retain expression immaturity markers such as doublecortin, slowly mature integrate into circuit animal ages. To study how early life experiences affect this cortical neurons, we submitted mice C57/Bl6J strain to protocol maternal separation for 3 h per day from...
Abstract In mammalian females, both adolescence and motherhood are critical periods modulating behavioural changes to favour evolutionary survival. mice, olfaction is a key driver of social behaviours, adult neurogenesis in the olfactory bulb an important form neural plasticity underlying adequate responses towards conspecifics. this study, we sought investigate whether transition adulthood would affect populations immature neurons described other areas system. To do so, analysed expression...
Abstract Background Prolactin (PRL) is an adenohypophyseal hormone with a key role in maternal and sexual behaviour, among multiple functions. Here, we sought to provide comprehensive description of the PRLergic system brain mice, describing sex differences plasticity this across reproductive stages females. Methods We describe neural prolactinergic using PRL antibody validated Prl-KO mouse tissue. This was carried out females different physiological (virgins, virgins experience pups...
Abstract Virgin female laboratory mice readily express maternal care when co-housed with dams and pups. However, pup-sensitized virgins fail to aggression on a single session of testing. To study whether repeated testing would affect the onset dynamics we tested their accompanying from postpartum day 4 6. Repeated led escalated towards male intruders in dams, but never developed aggression. In inhibition medial amygdala using DREADD (designer receptors exclusively activated by designer...