A5073505552- Computational Drug Discovery Methods
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Mosquito-borne diseases and control
- Malaria Research and Control
- Diverse Scientific Research Studies
- Pneumonia and Respiratory Infections
- Protein Structure and Dynamics
- Natural Antidiabetic Agents Studies
- HIV/AIDS drug development and treatment
- Antenna Design and Analysis
- Drug-Induced Hepatotoxicity and Protection
- Enzyme Catalysis and Immobilization
- Antibiotic Use and Resistance
- 3D Printing in Biomedical Research
- Synthesis and biological activity
- Distributed and Parallel Computing Systems
- Cholinesterase and Neurodegenerative Diseases
- Pharmaceutical Practices and Patient Outcomes
- Digital Imaging for Blood Diseases
- Plant Virus Research Studies
- Vaccine Coverage and Hesitancy
- Microbial Metabolic Engineering and Bioproduction
- vaccines and immunoinformatics approaches
University of Azad Jammu and Kashmir
2025
University of Management and Technology
2017-2023
Quaid-e-Awam University of Engineering, Science and Technology
2023
Islamia University of Bahawalpur
2023
Amity University
2021-2023
University of the Punjab
2015-2021
Information Technology University
2019-2021
Bahauddin Zakariya University
2017-2021
University of Engineering and Technology Peshawar
2020-2021
University of Peshawar
2021
Protein phosphorylation is one of the key mechanism in prokaryotes and eukaryotes responsible for various biological functions such as protein degradation, intracellular localization, multitude cellular processes, molecular association, cytoskeletal dynamics, enzymatic inhibition/activation. Phosphohistidine (PhosH) has a role number including central metabolism to signalling bacteria. Thus, identification phosphohistidine sites sequence crucial, experimental can be expensive, time-taking,...
Emerging research indicates interruptions in the wiring organization of brain network Mild cognitive impairment (MCI) and Alzheimer's disease (AD). Due to important role rich-club distinguishing abnormalities AD patients close relationship between structural connectivity (SC) functional (FC), our study examined whether changes SC-FC coupling with abnormal organizations during development diseases may contribute pathophysiology AD. Structural diffusion-tensor imaging (DTI) resting-state...
Dengue fever, caused by dengue virus (DENV), has become a serious threat to human lives. Phytochemicals are known have great potential eradicate viral, bacterial and fungal-borne diseases in beings. This study was aimed at silico drug development against nonstructural protein 4B (NS4B) of 4 (DENV4).A total 2750 phytochemicals from different medicinal plants were selected for this study. These grow naturally the climate Pakistan India been used treatment various pathologies long-time. The...
Methylation is one of the most important post-translational modifications in human body which usually arises on lysine among intensely modified residues. It performs a dynamic role numerous biological procedures, such as regulation gene expression, protein function and RNA processing. Therefore, to identify methylation sites an challenge some experimental procedures are time-consuming.Herein, we propose computational predictor named iMethylK_pseAAC sites.Firstly, constructed feature vectors...
Background: Carboxylation is one of the most biologically important post-translational modifications and occurs on lysine, arginine, glutamine residues a protein. Among all these three, covalent attachment carboxyl group with lysine side chain frequent type carboxylation. For studying such biological functions, it essential to correctly determine sites sensitive Objective: Herein, we present computational model for prediction carboxylysine site which based machine learning. Methods: Various...
Background: Among all the major post-translational modifications, amidation seems to be a small change, where peptide ends with an amide group (-NH 2), not carboxyl (-COOH). Thus, study their physicochemical properties, identification of mechanism is very important. However, in vitro, ex vivo and can laborious, time-taking costly. There dire need for efficient accurate computational model help researchers biologists identifying these sites, easy manner. Objectives: Herein, we propose novel...
Among all the PTMs, protein phosphorylation is pivotal for various pathological and physiological processes. About 30 percent of eukaryotic proteins undergo modification, leading to changes in conformation, function, stability, localization, so forth. In proteins, occurs on serine (S), Threonine (T) Tyrosine (Y) residues. these all, has its own importance as it associated with biological processes, including energy metabolism, signal transduction pathways, cell cycling, apoptosis. Thus,...
Background: Antibiotic resistance is a global threat. Scarce knowledge about safe and appropriate antibiotic use coupled with frequent self-administration, e.g., in China. This repeated self-medication poses potential risk terms of resistance. Low-resource countries are facing an elevated burden as compared to developed ones. Thus, this study focused on evaluating the pervasiveness 3 universities Southern Punjab, Pakistan. Methods: We conducted descriptive cross-sectional survey three...
Coronaviruses have been reported previously due to their association with the severe acute respiratory syndrome (SARS). After SARS, these viruses were known be causing Middle East (MERS) and caused 35% evanescence amid victims pursuing remedial care. Nowadays, beta coronaviruses, members of
Glycosylation of proteins in eukaryote cells is an important and complicated post-translation modification due to its pivotal role association with crucial physiological functions within most the proteins. Identification glycosylation sites a polypeptide chain not easy task multiple impediments. Analytical identification these expensive laborious. There dire need develop reliable computational method for precise determination such which can help researchers save time effort. Herein, we...
Background: IKV has been a well-known global threat, which hits almost all of the American countries and posed serious threat to entire globe in 2016. The first outbreak ZIKV was reported 2007 Pacific area, followed by another severe outbreak, occurred 2013/2014 subsequently, spread other islands. A broad spectrum associated neurological malformations neonates adults driven this deadly virus into limelight. Though tremendous efforts have focused on understanding molecular basis ZIKV, viral...
The present study aimed to assess and compare the ability remediate synthetic textile industrial wastewaters by Fenton treatment, a biological system sequential treatments using Aspergillus niger (A. niger). All studied were found be effective in decolorization of effluents under study. treatment followed A. showed excellent potential for maximum effectiveness was evaluated water quality parameters such as total organic carbon (TOC), Biological Oxygen Demand (BOD5) Chemical (COD) before...
At the end of December 2019, a novel strain coronavirus, given name 2019-nCoV, emerged for exhibiting symptoms severe acute respiratory syndrome. The virus is spreading rapidly in China and around globe, affecting thousands people leading to pandemic. To control mortality rate associated with prompt steps are needed. Until now there no effective treatment or drug present its life-threatening effects humans. scientist struggling find new inhibitors this deadly virus. In study, identify...
Background: Among all the major Post-translational modification, lipid modifications possess special significance due to their widespread functional importance in eukaryotic cells. There exist multiple types of and Palmitoylation, among them, is one broader having three different types. The N-Palmitoylation carried out by attachment palmitic acid an N-terminal cysteine. Due association with various biological functions diseases such as Alzheimer’s other neurodegenerative diseases, its...