Objective Both endoscopic sinus surgery (ESS) and biologic therapies have shown effectiveness for medically‐refractory chronic rhinosinusitis with nasal polyps (CRSwNP) without severe asthma. The objective was to evaluate cost‐effectiveness of dupilumab versus ESS patients CRSwNP. Study Design Cohort‐style Markov decision‐tree economic model a 36‐year time horizon. Methods A cohort 197 CRSwNP who underwent were compared matched 293 from the SINUS‐24 SINUS‐52 Phase 3 studies treatment 300 mg...

Abstract Objective Recent studies have identified an abundant source of multipotent progenitor cells in subcutaneous human adipose tissue, termed adipose‐derived adult stem (ADAS cells). In response to specific media formulations, including transforming growth factor β1 (TGFβ1), these exhibit significant ability differentiate into a chondrocyte‐like phenotype, expressing cartilage‐specific genes and proteins such as aggrecan type II collagen. However, the influence other factors on...

Background The coronavirus disease (COVID-19) is the latest pandemic of digital age. With internet harvesting large amounts data from general population in real time, public databases such as Google Trends (GT) and Baidu Index (BI) can be an expedient tool to assist health efforts. Objective aim this study apply epidemiology current COVID-19 determine utility providing adjunctive epidemiologic information on outbreaks evaluate methodology case future pandemics. Methods An time series...

Craniopharyngiomas and similar midline suprasellar tumors have traditionally been resected via transcranial approaches. More recently, expanded endoscopic endonasal transsphenoidal approaches gained interest. Surgeons advocated for both approaches, at present there is no consensus whether one approach superior to the other. The authors therefore compared surgical outcomes between craniotomy surgery (EETS) treated their institution.A retrospective review of patients undergoing resection...

Surgical treatment for chronic rhinosinusitis with nasal polyps (CRSwNP) is often followed by polyp regrowth return of symptoms. The purpose this study to identify clinical factors that influence the time interval revision sinus surgery in patients polyps.Retrospective cohort study.Records 299 individuals who underwent two or more surgeries diagnosis senior author (RM) from 1987 through 2011 were reviewed. between surgical interventions compared patient demographics, comorbidities,...

// Saroj K. Basak 1 , Alborz Zinabadi Arthur W. Wu Natarajan Venkatesan Victor M. Duarte 1,2 James J. Kang Clifton L. Dalgard 3 Meera Srivastava Fazlul H. Sarkar 4 Marilene B. Wang 1,2,5 and Eri S. Srivatsan 1,5 Department of Surgery, VA Greater Los Angeles Healthcare System, David Geffen School Medicine at University California Angeles, CA, USA 2 Head Neck Departments Anatomy, Physiology Genetics, Molecular Cell Biology, Uniformed Services University, Bethesda, MD, Karmanos Cancer...

To use an artificial intelligence (AI)-powered large language model (LLM) to improve readability of patient handouts.

Abstract Adipose‐derived adult stem (ADAS) cells represent an abundant population of multipotent mesodermal residing in various adipose tissue depots. ADAS cell preparations appear heterogeneous, yet at a clonal level, greater than 50% these exhibit multilineage differentiation potential. To date, there have been few attempts to define prospectively homogenous cells. In this study, we investigated whether aldehyde dehydrogenase (ALDH) can be used enrich with increased chondrogenic ALDH has...

To determine the long-term results of frontal sinus drillout (also known as modified Lothrop procedure) for treatment advanced disease.Retrospective review.The records patients who underwent by a single surgeon at an academic medical center from June 1995 through November 2011 were reviewed. Patient demographics and perioperative clinical findings analyzed their impact on surgical outcome. Failure was defined restenosis drainage pathways, necessitating additional surgery.A total 204 surgery...

The primary mode of viral transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is thought to occur through the spread droplets. objective this study was investigate droplet and splatter patterns resulting from common endoscopic endonasal procedures.Cadaver simulation series.Dedicated surgical laboratory.After instilling cadaver head specimens (n = 2) with fluorescein solution, procedures were systematically performed evaluate quantity, size, distance droplets following...

<i>Aims:</i> Survey the clinical symptoms, radiological features, management, and long-term outcomes of sinonasal anterior skull base schwannomas. <i>Patients Methods:</i> Retrospective review patients with schwannomas treated from June 2001 through January 2010 at two academic institutions. <i>Results:</i> There were 4 women 3 men in this study. The mean age was 46 years (range 17–68). tumor size 2.4 cm 1.4–3.8 cm). Tumor locations included ethmoid...

This study evaluates the patient experience during virtual otolaryngology clinic visits implemented coronavirus disease 2019 (COVID-19) pandemic. Patient satisfaction surveys were queried from January 1, 2020, to May for both telehealth and in-person visits. A descriptive analysis of question responses was performed. There 195 4013 with completed in this time period. Ratings related provider-patient communication poor Telehealth has become new norm most health care providers United States....

Background The taboo of avoiding nonsteroidal anti‐inflammatory drugs (NSAIDs) after functional endoscopic sinus surgery (FESS) has been waning. impetus to reduce opioid prescriptions in view the epidemic led authors change their practices include NSAIDs surgery. This study's aim was analyze differences between patients before and we began recommending FESS. Methods A prospective cohort study performed on undergoing FESS or other nasal surgeries at 3 institutions, by 5 rhinologists 1 facial...

Objective Studies have demonstrated improvement in Eustachian tube dysfunction (ETD) symptomatology after functional endoscopic sinus surgery (FESS); however, factors associated with ETD symptom alteration not been elucidated. This study evaluated and normalization of symptoms FESS. Methods A case‐control was performed FESS patients who had clinically significant based on the Tube Dysfunction Questionnaire‐7 (ETDQ‐7 ≥ 2.1) without middle ear effusion (MEE) preoperatively. Study were...

Background Chronic rhinosinusitis (CRS) has long been a suspected risk factor for Eustachian tube dysfunction (ETD). However, there have few studies quantifying the presence of ETD in CRS patients. We sought to determine prevalence symptoms patients undergoing functional endoscopic sinus surgery (FESS) using validated 7-item Tube Dysfunction Questionnaire (ETDQ-7) and correlate ETDQ-7 scores with symptom severity based on 22-item Sino-Nasal Outcome Test (SNOT-22). Methods Patients FESS were...

Real-time polymerase chain reaction using nasopharyngeal swabs is currently the most widely used diagnostic test for SARS-CoV-2 detection. However, false negatives and sensitivity of this mode testing have posed challenges in accurate estimation prevalence infection rates.