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Anniki Knop

ORCID: 0000-0001-8994-606X
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About
Contact & Profiles
A5026830066
Research Areas
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Single-cell and spatial transcriptomics
  • Immune cells in cancer
  • Tryptophan and brain disorders
  • Circadian rhythm and melatonin

Charité - Universitätsmedizin Berlin
 2018-2024

 Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry
OPENALEX - Publications 
Chotima Böttcher Stephan Schlickeiser Marjolein A. M. Sneeboer Désirée Kunkel Anniki Knop and 13 more Evdokia Paza Pawel Fidzinski Larissa Kraus Gijsje J. L. Snijders René S. Kahn Axel Schulz Henrik E. Mei Elly M. Hol Britta Siegmund Rainer Glauben Eike J. Spruth Lot D. de Witte Josef Priller

10.1038/s41593-018-0290-2 article EN Nature Neuroscience 2018-12-10
 Single-cell variations of circadian clock and immune gene expression in microglia and neurodegeneration
OPENALEX - Publications 
Koliane Ouk Müge Yalçin Ludovica Rigat Hadas Keren‐Shaul Eyal David and 6 more Anniki Knop Chotima Böttcher Achim Kramer Ido Amit Angela Relógio Josef Priller

Summary We investigated the diurnal rhythmicity of gene expression in microglia, resident macrophages brain, health and disease. Using RNA sequencing single-cell analysis by RNAscope, we examined wild-type mice R6/2 transgenic mouse model Huntington’s disease (HD). Our findings suggest context-dependent rhythmic exhibiting substantial variability between individual cells brain regions over 24 hours. Notably, observed loss key clock genes microglia from symptomatic but not presymptomatic...

10.1101/2024.06.16.599193 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-06-16
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