A5025875143- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- COVID-19 Clinical Research Studies
- Genetics and Neurodevelopmental Disorders
- Long-Term Effects of COVID-19
- Sirtuins and Resveratrol in Medicine
- Liver Disease Diagnosis and Treatment
- Biochemical effects in animals
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
Harvard University
2020-2024
Emory University
2024
Boston VA Research Institute
2020-2024
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a patient's age. Adults over 65 years age represent 80% hospitalizations have 23-fold greater risk death than those under 65. In the clinic, COVID-19 patients most commonly present with fever, cough dyspnea, from there can progress to acute respiratory distress syndrome, lung consolidation, cytokine release endotheliitis, coagulopathy, multiple organ failure death. Comorbidities such as cardiovascular disease,...
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a patient’s age. Over 80% hospitalizations are those over 65 years age with 23-fold greater risk death. In the clinic, COVID-19 patients most commonly present fever, cough dyspnea. Particularly in 65, it can progress to pneumonia, lung consolidation, cytokine release syndrome, endotheliitis, coagulopathy, multiple organ failure Comorbidities such as cardiovascular disease, diabetes, obesity...
Abstract Epigenetic “clocks” based on DNA methylation (DNAme) have emerged as the most robust and widely employed aging biomarkers, but conventional methods for applying them are expensive laborious. Here, we develop T agmentation-based Indexing M ethylation Seq uencing (TIME-Seq), a highly multiplexed scalable method low-cost epigenetic clocks. Using TIME-Seq, applied multi-tissue tissue-specific clocks to over 1,600 mouse samples. We also discovered novel approach age prediction from...
Aim: To assess real-world efficacy and safety of chronic Hepatitis C (HCV) treatment with direct acting antivirals (DAAs) in patients cirrhosis.
Epigenetic “clocks” based on DNA methylation (DNAme) are the most robust and widely-used aging biomarkers, but prevailing clock methods expensive laborious. Here, we describe Tagmentation-based Indexing for Methylation Sequencing (TIME-Seq), a highly-scalable approach low-cost epigenetic clocks. With TIME-Seq, predict age in 3,556 human mouse samples from nine tissue- cell-types. We show that TIME-Seq clocks accurate robust, enriched Polycomb Repressive Complex 2 (PRC2)-regulated loci,...