E. Meneghini
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Estrogen and related hormone effects
- Colorectal Cancer Screening and Detection
- Multiple and Secondary Primary Cancers
- Prostate Cancer Treatment and Research
- Acute Lymphoblastic Leukemia research
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
- Male Breast Health Studies
- Air Quality and Health Impacts
- HER2/EGFR in Cancer Research
- Economic and Financial Impacts of Cancer
- Advanced Breast Cancer Therapies
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Environmental Justice and Health Disparities
- Glioma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Metabolism, Diabetes, and Cancer
- Medication Adherence and Compliance
Fondazione IRCCS Istituto Nazionale dei Tumori
2009-2020
IRCCS Humanitas Research Hospital
2019
Laboratoire de Biométrie et Biologie Evolutive
2017
National Cancer Registry
2015
University of Genoa
2015
University of Milano-Bicocca
2015
University of Lübeck
2015
Istituto Superiore di Sanità
2015
Predictive Science (United States)
2009
European Institute of Oncology
2007
Because of large intra-individual variation in hormone levels, few studies have investigated the relation serum sex hormones to breast cancer (BC) premenopausal women. We prospectively studied this relation, adjusting for timing blood sampling within menstrual cycle. Premenopausal women (5,963), recruited Hormones and Diet Etiology Breast Tumors (ORDET) cohort study, provided a sample 20-24th day their After 5.2 years follow-up, 65 histologically confirmed BC cases were identified matched...
Purpose High endogenous testosterone is associated with increased breast cancer (BC) risk. We designed this study specifically to assess the long-term prognostic role of in a cohort postmenopausal BC patients. Patients and Methods considered 194 women, operated on for early (T1-2N0M0), who never received chemotherapy or hormonal therapy, participated fenretinide prevention trial as untreated controls. Blood samples were collected 3 months (median) after surgery; plasma samples, stored at...
Triple negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options. New opportunities are emerging from current comprehensive characterization of tumor immune infiltration and fitness. Therefore, effectiveness chemotherapies novel immunotherapies partially dictated by host inflammatory profiles. However, further progress in immuno-oncology required to reach a detailed awareness the infiltrate landscape determine additional reliable easily detectable biomarkers. In...
Aims and background The growing number of cancer survivors in Italy is expected to continue increase as a consequence population aging survival improvements, but few estimates are currently available, particularly on the national regional scale. purpose this work present detailed updated prevalence over period 1970-2010 by site (all cancers combined, stomach, colon rectum, lung, breast prostate) gender. Methods Prevalence was derived with MIAMOD statistical method, using cancer-specific...
The role of retinol (vitamin A) in breast cancer prognosis has never been investigated postmenopausal women. We prospectively assessed the long-term prognostic plasma levels a cohort patients.We 208 women self-reported as operated on for T(1-2)N(0)M(0) who participated chemoprevention trial controls and received chemotherapy or hormone therapy. Plasma samples were collected 3 months (median) after surgery assayed within weeks retinol. Minimum median potential follow-up 12 15 years,...
Abstract Androgens are involved in the development of breast cancer, although mechanisms remain unclear. To further investigate androgens we examined relations between serum testosterone and age, body mass index (BMI), tumor size, histologic type, grade, axillary node involvement, estrogen receptor status, progesterone HER2 overexpression a cross-sectional study 592 postmenopausal cancer patients. Mean differences according to categories patient characteristics were assayed by Fisher's or...
Androgen receptors (AR) are frequently expressed in breast cancers, but their implication cancer growth is still controversial. In the present study, we further investigated role of androgen/AR pathway development.AR expression was evaluated by immunochemistry a cohort 528 postmenopausal patients previously examined for association serum testosterone levels with patient and tumor characteristics. AR classified according to percentage stained cells: AR-absent (0%) AR-poorly (1%-30%),...