A5018190472- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Skin and Cellular Biology Research
- Hair Growth and Disorders
- Viral Infections and Immunology Research
- melanin and skin pigmentation
- Virus-based gene therapy research
- Poxvirus research and outbreaks
Infectiologie Animale et Santé Publique
2022-2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2022
Université de Tours
2021
Protocols allowing the in vitro culture of human hair follicles a serum free-medium up to 9 days were developed 30 years ago. By using similar protocols, we achieved prolonged maintenance juvenile feather (FF) microdissected from young chickens. Histology showed preservation FF 7 as well morphology compatible with growth and/or differentiation. The integrity wall epithelium was confirmed by transmission electron microscopy at Day 5 and culture. A slight elongation feathers detected for 75%...
Latency is a hallmark of herpesviruses, allowing them to persist in their host without virion production. Acute exposure hypoxia (below 3% O2) was identified as trigger latent-to-lytic switch (reactivation) for human oncogenic gammaherpesviruses (Kaposi's sarcoma-associated virus [KSHV] and Epstein-Barr [EBV]). Therefore, we hypothesized that could also induce reactivation Marek's disease (MDV), which shares biological properties with EBV KSHV (notably properties), lymphocytes. (1% two...
In vivo bioluminescence imaging facilitates the non-invasive visualization of biological processes in living animals. This system has been used to track virus infections mostly mice and ferrets; however, until now this approach not applied pathogens avian species. To visualize infection an important pathogen, we generated Marek’s disease (MDV) recombinants expressing firefly luciferase during lytic replication. Upon characterization recombinant viruses vitro , chickens were infected...