A5100384009- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Bee Products Chemical Analysis
- Urinary Bladder and Prostate Research
- Connexins and lens biology
- Genetic and Kidney Cyst Diseases
- Analytical Methods in Pharmaceuticals
- Adipokines, Inflammation, and Metabolic Diseases
- Dialysis and Renal Disease Management
- Extracellular vesicles in disease
- Pharmacogenetics and Drug Metabolism
- Medical and Biological Ozone Research
- Immune cells in cancer
- Laser Applications in Dentistry and Medicine
- Urinary Tract Infections Management
- Neuroscience and Neuropharmacology Research
- Inflammatory mediators and NSAID effects
- Retinopathy of Prematurity Studies
- Infectious Disease Case Reports and Treatments
- Amino Acid Enzymes and Metabolism
- Urologic and reproductive health conditions
- Advancements in Transdermal Drug Delivery
- Electrolyte and hormonal disorders
- Antibiotics Pharmacokinetics and Efficacy
- Urological Disorders and Treatments
Kaohsiung Chang Gung Memorial Hospital
2019-2022
Chang Gung University
2003-2022
National Tsing Hua University
2018
Harvard University
2014-2017
Smith-Kettlewell Eye Research Institute
2014-2017
Massachusetts Eye and Ear Infirmary
2014-2017
Novartis (China)
2015
Linkou Chang Gung Memorial Hospital
2010
Zhuhai People's Hospital
2005
Chang Gung Memorial Hospital
2003
To investigate the role of DJ-1 in Nrf2-regulated antioxidant defense corneal endothelial cells (CECs) at baseline and response to ultraviolet A (UV-A)-induced oxidative stress.DJ-1-deficient CECs were obtained by transfection an immortalized normal human cell line (HCECi) with small interfering RNA (siRNA) or isolation from ex vivo corneas knockout mice. Levels reactive oxygen species (ROS), protein carbonyls, Nrf2 subcellular localization, target genes, interaction between Keap1/Nrf2...
Background Accumulating evidence supports the important role of protein-bound uremic toxins such as indoxyl sulfate and p-cresol in syndrome. They exert direct deleterious effects on a variety cells could link to clinical outcome. Factors relevant levels peritoneal dialysis (PD) patients have rarely been investigated. We conducted cross-sectional study analyze factors that correlate with both total free p-cresol. Methods 182 stable PD mean therapy duration 38.5 ± 33.3 months were enrolled....
The effect of low energy shock wave (LESW) therapy on the changes inflammatory molecules and pain reaction was studied in a capsaicin (10 mM, 0.1 cc) induced prostatitis model rats. Intraprostatic injection reaction, including closing eyes, hypolocomotion, tactile allodynia, which effects were ameliorated by LESW treatment. (2Hz, flux density 0.12 mJ/mm2) at 200 300 shocks significantly decreased capsaicin-induced reactions, reflected reduction tissue edema cells, COX-2 TNF-α stained...
The oral bioavailability of diclofenac potassium 50 mg administered as a soft gelatin capsule (softgel capsule), powder for solution (oral solution), and tablet was evaluated in randomized, open-label, 3-period, 6-sequence crossover study healthy adults. Plasma concentrations were measured using validated liquid chromatography-mass spectrometry/mass spectrometry method, pharmacokinetic analysis performed by noncompartmental methods. median time to achieve peak plasma 0.5, 0.25, 0.75 hours...
Neurogenic inflammation and central sensitization play a role in chronic prostatitis/chronic pelvic pain syndrome. We explore the molecular effects of low-intensity shock wave therapy (Li-ESWT) on capsaicin-induced prostatitis rat model. Male Sprague-Dawley rats underwent intraprostatic capsaicin (10 mM, 0.1 cm3) injections. After injection, prostate received Li-ESWT twice, one day apart. The L6 dorsal root ganglion (DRG)/spinal cord was harvested for histology Western blotting days 3 7....
Renal abscesses in patients with end stage renal disease are quite rare, and misdiagnosis or delaying diagnosis is frequent. This report examines a case of abscess patient on maintenance hemodialysis diabetes mellitus, which presented prolonged fever. An infected diabetic foot was impressed initially. Purulent urine, pyuria, bacteriuria, bacteremia were noted after admission. diagnosed by percutaneous needle aspiration under computerized tomography guidance. The treated parenteral...