Jürgen C. Becker
A5067045121- Polyomavirus and related diseases
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Antenna Design and Analysis
- Full-Duplex Wireless Communications
- Cancer Immunotherapy and Biomarkers
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Bacteriophages and microbial interactions
- Plant Virus Research Studies
- Melanoma and MAPK Pathways
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Nonmelanoma Skin Cancer Studies
- Lymphoma Diagnosis and Treatment
- Dental Implant Techniques and Outcomes
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Fungal Infections and Studies
- Periodontal Regeneration and Treatments
- Cancer and Skin Lesions
- T-cell and Retrovirus Studies
- Peptidase Inhibition and Analysis
- Nail Diseases and Treatments
Essen University Hospital
2016-2025
German Cancer Research Center
2016-2025
Heidelberg University
2016-2025
University of Duisburg-Essen
2016-2025
Deutschen Konsortium für Translationale Krebsforschung
2016-2025
University Hospital Heidelberg
2006-2025
DKFZ-ZMBH Alliance
2019-2025
Heinrich Heine University Düsseldorf
2013-2024
German Marine Research Consortium
2015-2024
Düsseldorf University Hospital
2003-2024
Activating mutations in serine–threonine protein kinase B-RAF (BRAF) are found 50% of patients with advanced melanoma. Selective BRAF-inhibitor therapy improves survival, as compared chemotherapy, but responses often short-lived. In previous trials, MEK inhibition appeared to be promising this population.
The primary objective of this study was to confirm the efficacy romidepsin in patients with treatment refractory cutaneous T-cell lymphoma (CTCL).This international, pivotal, single-arm, open-label, phase II conducted stage IB IVA CTCL who had received one or more prior systemic therapies. Patients as an intravenous infusion at a dose 14 mg/m(2) on days 1, 8, and 15 every 28 days. Response determined by composite assessment total tumor burden including disease, lymph node involvement, blood...
Merkel cell carcinoma (MCC) is the most aggressive skin cancer. Recently, it was demonstrated that human polyomavirus (MCV) clonally integrated in approximately 80% of MCC tumors. However, direct evidence for whether oncogenic viral proteins are needed maintenance cells still missing. To address this question, we knocked down MCV T-antigen (TA) expression MCV-positive lines using three different short hairpin RNA (shRNA)-expressing vectors targeting exon 1 TAs. The used include newly...
Induction of p53 activity in cells undergoing DNA synthesis represents a molecular conflict that can lead to apoptosis. During angiogenesis, proliferative endothelial become apoptotic response antagonists integrin alphavbeta3 and this leads the regression angiogenic blood vessels, thereby blocking growth various human tumors. Evidence is presented administration during angiogenesis vivo selectively caused activation cell increased expression p53-inducible cycle inhibitor p21WAF1/CIP1. In...
Merkel cell polyomavirus (MCV) is a newly-discovered human tumor virus found in approximately 80% of carcinoma (MCC). The rate MCV infection among persons without MCC unknown. We developed virus-like particle (VLP) enzyme-linked immunoassay (EIA) that does not cross-react with BK or murine polyomaviruses. Peptide mapping the VP1 gene and immunoblotting denatured VLP are less sensitive than EIA detecting antibodies suggesting antibody reactivity this assay primarily targets conformational but...
BackgroundIn recent studies, convolutional neural networks (CNNs) outperformed dermatologists in distinguishing dermoscopic images of melanoma and nevi. In these artificial intelligence were considered as opponents. However, the combination classifiers frequently yields superior results, both machine learning among humans. this study, we investigated potential benefit combining human for skin cancer classification.MethodsUsing 11,444 images, which divided into five diagnostic categories,...
Schwarz F, Sahm N, Iglhaut G, Becker J. Impact of the method surface debridement and decontamination on clinical outcome following combined surgical therapy peri-implantitis: a randomized controlled study. J Clin Peridontol 2011; 38: 276–284. doi: 10.1111/j.1600-051X.2010.01690.x. Abstract Objectives: The study aimed at investigating impact two debridement/decontamination (DD) methods outcomes treatment peri-implantitis. Material Methods: Thirty-two patients suffering from advanced...
BackgroundRecently, convolutional neural networks (CNNs) systematically outperformed dermatologists in distinguishing dermoscopic melanoma and nevi images. However, such a binary classification does not reflect the clinical reality of skin cancer screenings which multiple diagnoses need to be taken into account.MethodsUsing 11,444 images, covered dermatologic comprising majority commonly pigmented lesions faced screenings, CNN was trained through novel deep learning techniques. A test set...
Anti-PD-1 therapy is used as a front-line treatment for many cancers, but mechanistic insight into this resistance still lacking. Here we generate humanized (Hu)-mouse melanoma model by injecting fetal liver-derived CD34+ cells and implanting autologous thymus in immune-deficient NOD-scid IL2Rγnull (NSG) mice. Reconstituted Hu-mice are challenged with HLA-matched melanomas treated anti-PD-1, which results restricted tumor growth not complete regression. Tumor RNA-seq, multiplexed imaging...