A5055799567- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Pneumonia and Respiratory Infections
- Microbial infections and disease research
- Oxidative Organic Chemistry Reactions
- Galectins and Cancer Biology
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Phytochemistry and Biological Activities
- Pneumocystis jirovecii pneumonia detection and treatment
- Phytochemistry and Bioactive Compounds
- Microbial Natural Products and Biosynthesis
- Crystal structures of chemical compounds
- Chemical Synthesis and Analysis
- Proteoglycans and glycosaminoglycans research
- Toxin Mechanisms and Immunotoxins
- Chemical synthesis and alkaloids
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Medicinal plant effects and applications
- Plant Disease Resistance and Genetics
- Isotope Analysis in Ecology
- Electron Spin Resonance Studies
- Pharmacology and Obesity Treatment
- Plant Pathogenic Bacteria Studies
- Phytochemistry and Bioactivity Studies
Griffith University
2016-2025
The University of Queensland
2009
Queensland University of Technology
1996-1997
University of Oxford
1989
To investigate the cytotoxic effect of some Bangladeshi medicinal plant extracts, 16 plants were successively extracted with n-hexane, dichloromethane, methanol and water. The methanolic aqueous extracts screened for activity against healthy mouse fibroblasts (NIH3T3) three human cancer-cell lines (gastric: AGS; colon: HT-29; breast: MDA-MB-435S) using MTT assay. Two (Hygrophila auriculata Hibiscus tiliaceous) one extract (Limnophila indica) showed no toxicity fibroblasts, but selective...
Acrostichum aureumL. (Pteridaceae), a mangrove fern, has been used as Bangladeshi traditional medicine for variety of diseases including peptic ulcer.Isolation and structural elucidation cytotoxic secondary metabolites from the methanol extract aerial parts A. aureum.Compounds were isolated using HPLC. The compound structures elucidated by 1D 2D NMR, MS other spectroscopic methods published data. compounds tested their activity against healthy cancer cells MTT assay. Active further evaluated...
Otitis media is an inflammatory disorder of the middle ear caused by airways-associated bacterial or viral infections. It one most common childhood infections as globally more than 80% children are diagnosed with acute otitis 3 years age and it a reason for doctor’s visits, antibiotics prescriptions, surgery among children. multifactorial disease various genetic, immunologic, infectious, environmental factors predisposing to develop Streptococcus pneumoniae, Haemophilus influenzae, Moraxella...
ABSTRACT We have determined the sequence of gene cluster encoding O antigen in Francisella novicida and compared it to previously reported O-antigen tularensis subsp. . Immunization with purified lipopolysaccharide (LPS) from F. or protected against challenge holarctica , respectively. The LPS did not confer protection Allelic replacement mutants which failed produce were attenuated, but exposure these induce a protective immune response. appeared be important for intracellular survival...
Abstract Galectin‐3 is extensively involved in metabolic and disease processes, such as cancer metastasis, thus giving impetus for the design of specific inhibitors targeting this β‐galactose‐binding protein. Thiodigalactoside (TDG) presents a scaffold construction galectin inhibitors, its inhibition galectin‐1 has already demonstrated beneficial effects an adjuvant with vaccine immunotherapy, thereby improving survival outcome tumour‐challenged mice. A novel approach—replacing galactose C2...
Bacterial lysate proteins (BLPs) serve as potential immunostimulants, recognized by pattern recognition receptors (PRRs) on immune cells, eliciting a robust response. In this study, THP-1 macrophages were treated with varying doses of BLPs derived from Streptococcus pyogenes (SP), agalactiae (SA), and Serratia marcescens (SM). The results showed significant increases (p < 0.05) in pro-inflammatory cytokines such TNF-α, IL-1β, IL-6, IL-12, granulocyte macrophage-colony stimulating factor...
Two new sesquiterpenes, (2R,3S)-sulfated pterosin C (1) and (2S,3S)-sulfated (2), along with two known derivatives, (2S,3S)-pterosin (2R)-pterosin P, were isolated from a methanolic extract of the aerial parts Acrostichum aureum. The structures 1 2 determined by interpretation their spectroscopic data. pterosins evaluated for cytotoxic activity against AGS, HT-29, MDA-MB-231, MCF-7 human cancer cell lines NIH3T3 normal mouse fibroblast line, using MTT assay. Compound showed IC50 values in...
Galectin-3 is a β-galactoside-specific, carbohydrate-recognizing protein (lectin) that strongly implicated in cancer development, metastasis, and drug resistance. promotes migration ability to withstand treatment of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells. Due high amino acid conservation among galectins the shallow nature their glycan-binding site, design selective potent antagonists targeting galectin-3 challenging. Herein, we report synthesis novel taloside-based...
Fifteen Australian macrofungi were investigated for cytotoxic activity. Ethanol, cold and hot water extracts of each species screened activity against normal mouse fibroblast cells (NIH/3T3), healthy human epithelial kidney (HEK-293), four cancer cell lines, gastric adenocarcinoma (AGS), two mammary gland (MDA-MB-231, MCF7) colorectal (HT-29) with a validated MTT assay. Most derived from Omphalotus nidiformis, Cordyceps cranstounii gunnii demonstrated significant toward variety lines. In...
PURPOSE: Blumea lacera (B. lacera) (Asteraceae) is a well-known Bangladeshi medicinal plant. This study aimed to identify and characterize constituents associated with the significant cytotoxic activity of this plant that we reported previously. Here, describe isolation characterization new steroidal glycoalkaloid (SGA) 1, evaluation its activity, apoptotic potential, effect on cell cycle in comparison analogous glycoalkaloids (SGAs). METHODS: SGA 1 was isolated using C18 SPE HPLC,...
Elucidation of the mechanism action compounds with cellular bioactivity is important for progressing into future drug development. In recent years, phenotype-based discovery has become dominant approach to over target-based discovery, which relies on knowledge a specific target disease. Still, when targeting an infectious disease via high throughput phenotypic assay it highly advantageous identifying compound’s activity. A fraction derived from plant Polyalthia sp. showed activity against...
Abstract Background Mushrooms have been recognized both as medicine and nutritional food in many countries for thousands of years, owing to the presence significant amounts carbohydrates, proteins, lipids, fibers, antioxidants. This study aims at evaluating contents antioxidant potentials seven types mushrooms cultivated Bangladesh. Methods Proximate composition analysis collected was performed determine moisture content, pH, lipid, crude fibre, total ash, protein, carbohydrate calorific...
A field study was conducted to investigate sewage inputs at popular anchorages in Moreton Bay, a sub-tropical, semi-enclosed embayment system Southeast Queensland, Australia. Sterol biomarkers were quantified sediments revealing low levels over spatial and temporal scale consistent with shallow, oligotrophic, highly dynamic, sand dominated system. Despite concentrations (ng/g) high variability, relevant sterol/stanol pairs remained well-correlated successful identifying an unexpected...
Abstract Background Campylobacter jejuni is a major bacterial cause of food-borne enteritis, and its lipooligosaccharide (LOS) plays an initiating role in the development autoimmune neuropathy, Guillain-Barré syndrome, by induction anti-neural cross-reactive antibodies through ganglioside molecular mimicry. Results Herein we describe existence heterogeneity multiple LOS forms C. strains human chicken origin grown at 37°C 42°C, respectively, as determined on sodium dodecyl...
A new diterpenoid glycoside, 6E,10E,14Z-(3S)-17-hydroxygeranyllinalool-17-O-β-d-glucopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl-(1 6)]-β-d-glucopyranoside (1) together with the known glycoside (2) and two flavonoid glycosides (3, 4) were isolated from methanol extract of Blumea lacera leaves. The structures determined by interpretation their spectroscopic data comparison literature. All compounds for first time B. evaluated cytotoxic activity. Only compound showed strong activity lowest IC50...