A5044848167- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- Advanced Nanomaterials in Catalysis
- Orthopaedic implants and arthroplasty
- Marine Biology and Environmental Chemistry
- Nanoplatforms for cancer theranostics
- Thallium and Germanium Studies
- Bone health and osteoporosis research
- Dental Implant Techniques and Outcomes
- Plant Pathogens and Fungal Diseases
- Electrospun Nanofibers in Biomedical Applications
- Bone and Dental Protein Studies
- Plant-Microbe Interactions and Immunity
- Laser-Ablation Synthesis of Nanoparticles
- Magnesium Alloys: Properties and Applications
- Mycorrhizal Fungi and Plant Interactions
- Business and Management Studies
- Medical and Biological Ozone Research
- Collagen: Extraction and Characterization
- Trace Elements in Health
- Magnesium in Health and Disease
- Calcium Carbonate Crystallization and Inhibition
- Cellular Mechanics and Interactions
- Child Abuse and Trauma
- Blood properties and coagulation
Universitat Jaume I
2019-2025
University of Aveiro
2017-2024
Escola Superior de Saúde Egas Moniz
2023
Several studies showed that adults who have experienced childhood adversity are more likely to develop alexithymia and low empathy. Therefore, this research aims analyze the relationship between empathy in adulthood verify a predictive explanatory model of alexithymia. The sample comprised 92 responded sociodemographic questionnaire, Childhood History Questionnaire, Interpersonal Reactivity Index, Alexithymia Scale Toronto. positive with negative Predictive validity marital status, adverse...
Quercetin (QUE), a natural flavonoid found in various fruits and vegetables, has diverse biological functions, including anti-inflammatory effects, regulation of cell adhesion oxidative stress mitigation. In this study, sol-gel...
Abstract Background Calcium (Ca) is a well-known element in bone metabolism and blood coagulation. Here, we investigate the link between protein adsorption pattern vivo responses of surfaces modified with calcium ions (Ca-ion) as compared to standard titanium implant (control). We used LC–MS/MS identify proteins adhered after incubation human serum performed bilateral surgeries medial section femoral condyles 18 New Zealand white rabbits test osseointegration at 2 8 weeks post-implantation (...
Pine pitch canker (PPC), caused by Fusarium circinatum , affects Pinus species worldwide. Although no effective solutions have yet been found to control it, there is a growing interest in using biological agents (BCA) such as Trichoderma avoid the application of chemical‐based products. Using with an increasing level susceptibility PPC ( pinea pinaster and radiata ), this study aimed evaluate effect viride pre‐inoculation on disease development, assessing several physiological hormonal...
Abstract Calcium ions are used in the development of biomaterials for promotion coagulation, bone regeneration, and implant osseointegration. Upon implantation, time-dependent release calcium from titanium surfaces modifies physicochemical characteristics at implant–tissue interface thus, biological responses. The aim this study is to examine how dynamics protein adsorption on these change over time. Titanium discs with without Ca were incubated human serum 2 min, 180 960 min. layer proteins...
The cell-biomaterial interface is highly complex; thousands of molecules and many processes participate in its formation. Growing demand for improved biomaterials has highlighted the need to understand structure functions this interface. Proteomic methods offer a viable alternative traditional vitro techniques analyzing such systems. Magnesium promoter cell adhesion osteogenesis. Here, we used LC-MS/MS compare protein expression profiles human osteoblasts (HOb) exposed sol-gel coatings...
A strong seal of soft-tissue around dental implants is essential to block pathogens from entering the peri-implant interface and prevent infections. Therefore, integration poses a challenge in implant-prosthetic procedures, prompting focus on between soft-tissues transmucosal component. The aim this study was analyse effects sandblasted roughness levels vitro healing implant abutments. In parallel, proteomic techniques were applied interaction these surfaces with human serum proteins...
Abstract Titanium is widely used in bone prostheses due to its excellent biocompatibility and osseointegration capacity. To understand the effect of sandblasted acid‐etched (SAE) Ti implants on biological responses human osteoblast (HOb), their proteomic profiles were analyzed using nLC‐MS/MS. The cells cultured with implant materials, 2544 distinct proteins detected samples taken after 1, 3, 7 days. Comparative analyses data performed Perseus software. expression related EIF2, mTOR,...
This study explores the osteogenic potential of unicCa implants via advanced proteomics. Enhanced cell adhesion, functions and diminished immune response were found to correlate under both in vitro vivo conditions.
This study is performed with the aim of enhancing cell response to titanium surfaces through sandblasting and pink anodizing (MC04 + PA), correlating in vitro findings protein adsorption patterns.
Poor correlation between the results of in vitro testing and subsequent vivo experiments hinders design biomaterials. Thus, new characterisation methods are needed. This study used proteomic histological techniques to analyse effects Ca-doped biomaterials verify two systems. The sol-gel route was employed synthesise coatings functionalised with 0.5 5 wt% CaCl2. Morphology examined using SEM; Ca2+ ion release from materials analysed by means ICP-AES spectroscopy. osteogenic inflammatory...
Bioactive CaMg-coatings were designed and characterized, showing that the CaMg-mixtures’ biological impact is not just a sum of individual effects.
Strontium plays an important role in bone regeneration; it promotes the differentiation and maturation of osteoblasts inhibits activity osteoclasts. Our principal objective this study was to formulate new organic-inorganic hybrid sol-gel coatings applied titanium discs. These were functionalised with different amounts SrCl2 examined using vitro tests proteomics. The chemical morphological characteristics obtained scrutinised. evaluation MC3T3-E1 RAW264.7 macrophages showed osteogenic...
New osteogenic and antibacterial Cu-sol–gel coatings were developed widely characterized, deepening the understanding of Cu-biomaterial mechanisms to kill pathogens.
The success of bone implants depends on the osteoimmunomodulatory (OIM) activity biomaterials in interactions with periimplantary tissues. Many vitro tests have been conducted to evaluate osteoimmunology effects biomaterials. However, results these often inconclusive. This study examines properties newly developed sol-gel coatings doped two metal ions associated regeneration, Ca and Zn. uses both proteomic methods traditional assays. demonstrate that proteomics is an effective tool...
Abstract The immune system plays a crucial role in determining the implantation outcome, and macrophages are frontline of inflammatory processes. Further, cellular oxidative stress resulting from material recognition can influence how cell responses develop. Considering this, aim this study was to phenotypes response sol–gel materials with distinct vivo outcomes. Four were selected (70M30T 35M35G30T, high biocompatibility, 50M50G 50V50G, low biocompatibility). Gene expression,...
Abstract Multicompartmental capsules have demonstrated value in fields ranging from drug release, mimetics of artificial cells, to energy conversion and storage. However, the fabrication devices with different compartments usually requires use toxic solvents, and/or adaptation technically demanding methods, including precision microfluidics multistep processes. The spontaneous formation multi‐core resulting polyelectrolyte complexation at interface a prototypic all‐aqueous two‐phase system...