A5069624533- Clinical Nutrition and Gastroenterology
- Hematopoietic Stem Cell Transplantation
- Nutrition and Health in Aging
- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- BRCA gene mutations in cancer
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Intensive Care Unit Cognitive Disorders
- Autoimmune Bullous Skin Diseases
- Cellular transport and secretion
- Congenital heart defects research
- Enhanced Recovery After Surgery
- Bone Metabolism and Diseases
- Protein Interaction Studies and Fluorescence Analysis
- T-cell and B-cell Immunology
- Acute Myeloid Leukemia Research
- COVID-19 Clinical Research Studies
- Olfactory and Sensory Function Studies
- Cytomegalovirus and herpesvirus research
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Wnt/β-catenin signaling in development and cancer
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders
- NF-κB Signaling Pathways
University of Toronto
1997-2025
Sunnybrook Health Science Centre
2023-2025
Health Sciences Centre
2023-2025
Baylor College of Medicine
2024
University of Colorado Denver
2019-2021
National University of Singapore
2003
Ontario Institute for Cancer Research
1996-1999
Amgen (Canada)
1996-1999
Amgen (United States)
1999
Amgen (Germany)
1997
Mark A. Lomaga, Wen-Chen Yeh, Ildiko Sarosi, Gordon S. Duncan, Caren Furlonger, Alexandra Ho, Sean Morony, Casey Capparelli, Gwyneth Van, Stephen Kaufman, Annette van der Heiden, Annick Itie, Andrew Wakeham, Wilson Khoo, Takehiko Sasaki, Zhaodan Cao, Josef M. Penninger, Christopher J. Paige, David L. Lacey, Colin R. Dunstan, William Boyle, V. Goeddel, and Tak W. Mak Department of Pharmaceutical Sciences, Faculty Pharmacy, University Toronto, Ontario, Canada M5S 2S2; Amgen Institute, Ontario...
Mutations of the tumor suppressor gene BRCA2 are associated with predisposition to breast and other cancers. Homozygous mutant mice in which exons 10 11 Brca2 were deleted by targeting (Brca2(10-11)) die before day 9.5 embryogenesis. Mutant phenotypes range from severely developmentally retarded embryos that do not gastrulate reduced size make mesoderm survive until 8.5 days development. Although apoptosis is normal, cellular proliferation impaired Brca2(10-11) mutants, both vivo vitro. In...
Collagen-induced arthritis (CIA) is an experimental autoimmune disease induced by immunization with collagen type II (CII). We studied CIA in CD4- or CD8-deficient DBA/1 mice to further define the roles of CD4+ and CD8+ T cells disease. CD4-deficient developed severe arthritis, no differences incidence, clinical course, severity were observed between CD4 -/- +/- mice. Proliferative responses lymph node CII was, however, reduced mice, inflamed joints revealed relative accumulation...
Abstract Background Better understanding the impact of dietetic services on nutrition practices seems required as it may represent an opportunity for optimization in post–cardiac surgery patients. The present study aims to evaluate and compare clinical outcomes intensive care unit (ICU) patients with without services. Methods This is a secondary analysis multinational prospective observational ( n = 237) >72 h surgical ICU stay describing up 12 days after admission. Results Dietetic were...
Cardiac surgery patients with a prolonged stay in the intensive care unit (ICU) are at high risk for acquired malnutrition. Medical nutrition therapy practices cardiac unknown. The objective of this study is to describe current critically ill worldwide.We conducted prospective observational 13 international ICUs involving mechanically ventilated an ICU least 72 h. Collected data included energy and protein prescription, type time initiation nutrition, actual quantity delivered (maximum: 12...
Kinectin has been proposed to be a membrane anchor for kinesin on intracellular organelles. A kinectin isoform that lacks major portion of the kinesin-binding domain does not bind but interacts with another resident endoplasmic reticulum, translation elongation factor-1 delta (EF-1δ). This was shown by yeast two-hybrid analysis and number in vitro vivo assays. EF-1δ provides guanine nucleotide exchange activities EF-1α during step protein synthesis. The minimal EF-1δ-binding resides within...
Patients with COVID-19 most commonly report respiratory symptoms, a minority reporting gastrointestinal (GI) symptoms in currently available reports. Additionally, little is known about the of anosmia/hyposmia, ageusia, and dysgeusia anecdotally seen patients, which may potentially be considered both GI sensory/neurological manifestations infection. We hope to clarify prevalence these patterns transmission within family cluster. interviewed 7 patients via oral inquiries questionnaire,...
We describe a case of Cryptococcal choroiditis in person with advanced HIV/AIDS. A 29-year-old male AIDS presented fever, photophobia, and ataxia secondary to cryptococcal toxoplasma meningoencephalitis. Dilated fundoscopic examination revealed bilateral multifocal posterior infiltrates consistent choroiditis. Treatment parenteral intravitreal liposomal amphotericin B, oral flucytosine, trimethoprim-sulfamethoxazole led resolution his symptoms improvement vision. Our documents rare,...
Heterozygous pathogenic variants in