A5087527021- Animal Nutrition and Physiology
- Animal Behavior and Welfare Studies
- Stress Responses and Cortisol
- Gut microbiota and health
- Circadian rhythm and melatonin
- Exercise and Physiological Responses
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Veterinary Equine Medical Research
- Phytase and its Applications
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Contact Dermatitis and Allergies
- Livestock and Poultry Management
- Aquaculture disease management and microbiota
- Probiotics and Fermented Foods
- Pharmacological Effects and Assays
- Reproductive Physiology in Livestock
- CAR-T cell therapy research
- Animal health and immunology
- Occupational exposure and asthma
- Immunotoxicology and immune responses
- Allergic Rhinitis and Sensitization
- Animal testing and alternatives
- Receptor Mechanisms and Signaling
University of Hohenheim
2014-2024
University of Rostock
2022
Miltenyi Biotec (Germany)
2008-2013
Animal Welfare Institute
2013
Collège de France
2010
Institut de génétique et de biologie moléculaire et cellulaire
2010
Modification of proteins by reactive small chemicals is a key step in the activation chemical-specific T cells allergic contact dermatitis (ACD). However, an integrated approach to characterize both precise nature chemically modified and currently lacking. Here, we analyze molecular conditions for adduct formation strong human sensitizer 2,4-dinitrochlorobenzene (DNCB) its water-soluble form, 2,4-dinitrobenzenesulfonic acid (DNBS), with all amino acid–containing model peptide (± Cys) protein...
Immunocastration is a sustainable alternative to piglet castration but faces limited market acceptance. The phenomenon of non-responders has not date been examined in detail, adverse and stressful housing conditions (e.g., mixing groups) might impair the success vaccinations. Therefore, we evaluated influence on immune response after two Improvac® vaccinations at an age 12 22 weeks, respectively. Boars, immunocastrates barrows (n = 48 each) were assigned three different 36 enriched, n...
Insufficient nutrient supply can impair the immune system, which is important for animal health and welfare. Since chicken partly hydrolyze phytate, primary phosphorus storage in plant seeds, a reduction of mineral diets could be an option more sustainable egg production. Laying hens require high concentrations calcium that might inhibit function endogenous enzymes phytate hydrolyzation. The objective this study was to characterize impact standard reduced dietary on number functionality...
Already during early life, chickens need to cope with chronic stressors that can impair their health and welfare, stocking density being one of the most influential factors. Nevertheless, there is a gap in research on influence laying hens rearing subsequent period. This study therefore investigated how affects immune system welfare pullets, whether effects are persistent later life. Pullets were reared at either low (13 birds/m2) or high (23 densities but identical group sizes from wk 7 17....
Domestic horses are currently often subject to management practices that can entail social stressors, which in turn negatively influence immunocompetence and disease susceptibility. The present study therefore aimed characterize the number of various blood leukocyte subsets horses, focusing on two potentially stressful housing environments: changes group composition relocation individual stabling. Immune measurements were conducted before as well one eight days after made. They complemented...
The objective of this study was to characterize intestinal phytate degradation and mineral utilization by 2 laying hen strains before after the onset egg using diets without or with a phosphorus (P) supplement. One offspring 10 roosters per strain (Lohmann Brown-classic [LB] Lohmann LSL-classic [LSL]) sacrificed (wk 19) 24) egg-laying activity following 4 wk placement in metabolic unit. Diets were corn-soybean meal-based supplemented P (P-) 1 g/kg (P+) from monocalcium phosphate. In 19 24,...
Abstract Despite the importance of pigs (Sus scrofa domestica) in livestock production and their increasing role as a model organism for human physiology, knowledge about porcine immune system under influence stress hormones is fragmentary. Exceptionally little known effects catecholamines. Therefore, aim this study was to examine vivo adrenaline, noradrenaline, cortisol on number functionality blood cells. Castrated male (n = 34) were treated with physiological doses either or via i.v....
During life, the number and function of immune cells change with potential consequences for immunocompetence an organism. In laying hens, studies have primarily focused on early development competence only few investigated systemic lymphatic distribution leukocyte subsets during adolescence egg-laying period. The present study determined various types in blood, spleen, cecal tonsils 10 Lohmann Brown-Classic LSL-Classic hens per wk life 9/10, 15/16, 23/24, 29/30, 59/60, encompassing important...
Abstract Determining the abundance of leukocyte subtypes, including lymphocyte subpopulations, not only in blood but also lymphatic tissues, is inevitable to assess immune status an organism for research purposes. However, nucleated thrombocytes and erythrocytes exacerbate many hematological techniques avian species. In order enable a rapid discrimination subsets from tissues chicken, we adapted existing flow cytometric methods counting leukocytes chicken blood. We established staining...
Abstract The present study assessed effects of diets containing varying calcium–phosphorus (CaP) concentration and fermentable substrates on digestibility diets, intestinal microbiota immune system using 32 crossbred pigs (initial BW 54.7 kg). In a 2 × factorial arrangement, were fed either corn–soybean meal (CSB) or corn–field pea (CFP) diet with low [‐] (4.4 g Ca/kg; 4.2 total P/kg) high [+] (8.3 7.5 P/kg; supplemented monocalcium phosphate) CaP content for period 9 weeks. week 8, blood...
Stress hormones exert important modulating influences on the functionality of immune cells. Despite its major role as a livestock animal and increasing use an model, knowledge about this relationship in domestic pig is rare. This study therefore aimed to characterize effect glucocorticoids catecholamines proliferation cytokine production porcine peripheral blood mononuclear cells (PBMC). Blood was obtained from donor pigs equipped with indwelling catheters exclude stress hormone exposition...
In pig production, pregnant sows are either housed in individual crates or groups, the latter being mandatory EU since 2013. The consequences of different housing conditions on immune system however poorly investigated, although immunological alterations may have severe for animal's health, performance, and welfare. This study assessed measures blood celluar immunity with special emphasis T cells German Landrace a social group. Blood samples were taken at four samplings pre partum to...
Housing conditions might differentially affect the adaptive immune responses to a neoantigen in pregnant sows with possible consequences for success of vaccinations. Therefore, this study aimed at characterizing antigen-specific T cell and B (German Landrace) either housed social group (GP; n = 22) or confined individual gestation crates (CR; 11). All were immunized keyhole limpet hemocyanin (KLH) 7 5 wk prepartum. Blood samples taken 7, 6, 4, 2 prepartum, thus before after first as well...
The objectives of this study were to investigate whether an increased dietary myo-inositol (MI) supply translates into changes in MI concentrations and endogenous mucosal phosphatase activities the intestine laying hens different hen strains respond differently supplementation. diets corn-soybean meal-based supplemented without (MI0) or with 1 (MI1), 2 (MI2), 3 (MI3) g MI/kg feed. Ten per strain (Lohmann Brown-classic (LB) Lohmann LSL-classic (LSL)) diet sacrificed at age 30 wk following a...
The photoperiod is known to modulate immune cell number and function regarded essential for seasonal disease susceptibility. In addition, diurnal variations in the system are important competence. Whereas few studies investigated influence of season, none specific effect on these rhythms until now. Therefore, present study compared numbers peripheral leukocyte types domestic pigs held either under long day conditions (LD) or short (SD). Cosinor analyses various subtypes over periods 50 hours...
Lohmann Brown (LB) and Selected Leghorn (LSL) are two commercially important laying hen strains due to their high egg production excellent commercial suitability. The present study integrated multiple data sets along the genotype-phenotype map better understand how genetic background of influences molecular pathways. In total, 71 individuals were analyzed (LB, n = 36; LSL, 35). Data include gut miRNA mRNA transcriptome data, microbiota composition, immune cells, inositol phosphate...