A5000761619- Eicosanoids and Hypertension Pharmacology
- Spectroscopy and Quantum Chemical Studies
- Biomedical Text Mining and Ontologies
- Pharmacogenetics and Drug Metabolism
- Alcohol Consumption and Health Effects
- Inflammatory mediators and NSAID effects
- Molecular Spectroscopy and Structure
- Genomics and Rare Diseases
- Advanced Chemical Physics Studies
- RNA and protein synthesis mechanisms
- Receptor Mechanisms and Signaling
- Machine Learning in Bioinformatics
- Bioinformatics and Genomic Networks
- Protein Structure and Dynamics
- Fractal and DNA sequence analysis
- Molecular spectroscopy and chirality
- Hormonal Regulation and Hypertension
- Gene expression and cancer classification
- Mass Spectrometry Techniques and Applications
- Click Chemistry and Applications
GlaxoSmithKline (United States)
2017-2019
Target (United States)
2017
Washington University in St. Louis
1998
University of Michigan
1996
The Fourier transform infrared (FTIR) spectra of several coiled-coil proteins have been shown to possess unusual features in the amide I' region. Band maxima occur vicinity 1630 cm-1, with component bands at higher frequency. This is well below observed band 1650 cm-1 found standard α-helical polypeptides such as poly-l-alanine. Normal mode calculations on models structure performed investigate this issue. We find that profile can be reproduced very small random variations φ,ψ tropomyosin....
Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which metabolized EPHX2 (epoxide hydrolase 2, alias soluble epoxide or sEH). EETs have pleiotropic effects, including anti-inflammatory activity. Using a Connectivity Map (CMAP) approach, we identified an inverse-correlation between exemplar inhibitor (EPHX2i) compound response and inflammatory bowel disease patient-derived signature. To validate the gene-disease link, tested...
In order to obtain accurate normal modes of proteins, which is a prerequisite for detailed analyses in variety vibrational spectroscopic techniques, reliable conformation-dependent force fields are required. We discuss the use empirical polypeptide this purpose, since they have generally been quite successful reproducing spectra synthetic polypeptides. Although their limitations motivating our development spectroscopically determined field (SDFF), can still provide important insights into...
Abstract The objective of this study was to test a topical formulation EPHX2 inhibitor, GSK2256294, in dermal wound diabetic (db/db) mouse model. Comparisons were made between groups treated with matching vehicle control and currently approved treatment for ulcers, becaplermin/Regranex, as positive which is highly efficacious Leptin receptor-deficient male mice sequentially assigned (N=10 per group) based on blood glucose levels body weight. Mice given single 8 mm diameter full thickness the...