Objectives To measure exclusion of elderly adults from randomized trials studying drug interventions for ischemic heart disease ( IHD ) and describe the characteristics these trials. Design Cross‐sectional analysis. Setting Interventional clinical a intervention that started in 2006 after were identified ClinicalTrials.gov. Data extracted on study features, including age‐based inclusion criteria. participants their age distribution collected trial publications, investigator inquiry, result...

Many medicines prescribed to children have not been studied or formally approved for pediatric use. The Pediatric Research Equity Act of 2003 authorized the US Food and Drug Administration (FDA) require clinical studies.To evaluate characteristics, completion rate, transparency study design results mandatory postmarketing studies required under Act.A retrospective cohort was conducted new drugs indications by FDA between January 1, 2007, December 31, 2014, with follow-up through 2017....

The Research to Accelerate Cures and Equity (RACE) for Children Act was enacted in 2017 authorize the US Food Drug Administration (FDA) require pediatric studies new cancer drugs that have a molecular target relevant growth or progression of cancer. To assess possible scope this policy, we examined all 78 adult approved by FDA from 2007 2017. Only 17 (21.8%) received any labeling information. Based on FDA's Pediatric Molecular Target List, found RACE could increased proportion potentially...

Objectives: Investigate associations of healthier behaviors with 30-yr cancer incidence.Subjects/Methods: In 1982, 632 healthy men and women (ages 40–70) were interviewed for nutritional habits using a Food Frequency Questionnaire 24-h physical activity questionnaire. Blood pressure, weight, height measured, blood was drawn biochemical profiles. Thirteen four subjects excluded due to diagnosis ≤1 yr from recruitment extreme values reported total daily calorie intake, respectively.Results:...

Abstract Background Socioeconomic differences in oral health and dental care utilization are a persistent problem many high-income countries. We evaluated demographic, geographic socioeconomic factors associated with disparities households’ out-of-pocket expenditure (OOPE) on care, the effect of ongoing reform these disparities. Methods This cross-sectional analysis used data collected two Israeli Household Expenditure Surveys conducted 2014 2018. OOPE for was estimated using two-part...

ObjectivesTo explore admission and discharge prescription rates of guideline-directed medical therapy (GDMT), defined as aggregate antiplatelet agents, statins, β-blockers, after coronary artery bypass graft (CABG) surgery to reveal its association with long-term survival.Patients MethodsThis is a prospective cohort study–based emulated trial patients undergoing elective or semi-elective isolated CABG in 7 cardiothoracic units Israel from January 1, 2004, December 31, 2007, followed up until...

Abstract Objectives We investigated associations with re-hospitalization, and intermediate- long-term mortality, of cardio-thoracic surgeons' adherence to pharmacological guideline-directed medical therapy (GDMT) in discharge recommendations coronary artery bypass graft (CABG) surgery patients. Methods In this longitudinal multicenter study, 1,131 patients who underwent elective CABG seven centers during 2004–2007 were interviewed the hospital before surgery. Adherence surgeons GDMT was...

Objective: Few new therapies have been approved for pediatric cancers. In 2017, Congress enacted the Research to Accelerate Cures and Equity (RACE) Children Act, which requires studies adult cancer drugs with a molecular target relevant cancer. The study requirements will apply by FDA beginning in 2020. To inform implementation of this law, we evaluated trials labeling information available FDA.Methods: We identified from January 2007 December 2017 using Drugs@FDA database. New formulations,...

Abstract Objective: Few new therapies have been approved for pediatric cancers. In 2017, Congress enacted the Research to Accelerate Cures and Equity (RACE) Children Act, which requires studies adult cancer drugs with a molecular target relevant cancer. The study requirements will apply by FDA beginning in 2020. To inform implementation of this law, we evaluated trials labeling information available FDA. Methods: We identified from January 2007 December 2017 using Drugs@FDA database. New...

Background: Guideline-directed medical therapy (GDMT) is underused in coronary artery bypass graft (CABG) surgery patients. Randomized controlled trials on GDMT and survival would be unethical. We investigated the association between professionals' adherence to recommending CABG patients’ hospital discharge letter long-term survival.Methods: Patients who received isolated seven centers Israel during 2004-2007, survived in-hospital 30-day post-surgery, participated this longitudinal study...