A5069437723- Synthesis and Biological Evaluation
- Research on Leishmaniasis Studies
- Synthesis and biological activity
- Malaria Research and Control
- Cancer therapeutics and mechanisms
- Trypanosoma species research and implications
- HIV/AIDS drug development and treatment
- Quinazolinone synthesis and applications
- Computational Drug Discovery Methods
- Bioactive Compounds and Antitumor Agents
- Synthesis and Characterization of Heterocyclic Compounds
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Chemical Synthesis and Analysis
- Synthesis and Catalytic Reactions
- Tuberculosis Research and Epidemiology
North-West University
2016-2022
Leishmaniasis is a vector-borne neglected parasitic infection affecting thousands of individuals, mostly among populations in low- to moderate-income developing countries. In the absence protective vaccines, management disease banks solely on chemotherapy. However, clinical usefulness current antileishmanial drugs threatened by their toxicity and emergence multidrug-resistant strains causative pathogens. This emphasizes imperative for development new effective agents. this regard, we...
Abstract Currently available drugs being used to treat leishmaniasis have several shortcomings, including high toxicity, drug administration that requires hospitalization, and the emergence of parasite resistance against clinically drugs. As a result, there is dire need for development new antileishmanial are safe, affordable, efficient. In this study, two series synthesized quinazolinone derivatives were investigated as potential future agents, by assessing their activities Leishmania ( L...
Leishmaniasis is a major vector-borne parasitic disease that affects thousands of people in tropical and subtropical developing countries. In 2019 alone, it killed 26,000-65,000 individuals. curable, yet its eradication elimination are hampered by hurdles, such as the availability only handful clinical toxic drugs emergence pathogenic resistance against them. This underscores imperative need for new effective antileishmanial drugs. search agents, we synthesized evaluated vitro potential...
Leishmaniasis is a vector-borne parasitic disease that mostly affects populations in tropical and sub-tropical countries. There currently no protective anti-leishmanial vaccine only paucity of clinical drugs available to treat this albeit their toxicity. curable but its eradication elimination have been hampered by the emergence multidrug resistant strains causative pathogens. This heightens necessity for new effective antileishmanial drugs. In search such agents, nitrofurantoin, antibiotic,...
Leishmaniasis is a vector-borne parasitic disease that mostly affects populations in tropical and sub-tropical countries. There currently no protective anti-leishmanial vaccine only paucity of clinical drugs available to treat this albeit their toxicity. curable but its eradication elimination have been hampered by the emergence multidrug resistant strains causative pathogens. This heightens necessity for new effective antileishmanial drugs. In search such agents, nitrofurantoin, antibiotic,...
Molecular hybridization is an increasingly important strategy in rational drug design and development.A series of novel quinazolinone-triazole hybrids have been synthesized their antileishmanial activity investigated.Derivatives (E)-3-(prop-2-yn-1-yl)-2-styrylquinazolin-4(3H)-one, (E)-3-{[1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl]methyl}-2-styrylquinazolin-4(3H)-one were observed to moderately inhibit the growth promastigotes.An overall lack significant may be attributable poor aqueous...