A5057424623- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Parathyroid Disorders and Treatments
- Peptidase Inhibition and Analysis
- Vitamin D Research Studies
- Endometrial and Cervical Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Uterine Myomas and Treatments
- Bone health and osteoporosis research
- Pediatric Hepatobiliary Diseases and Treatments
- Genetic Associations and Epidemiology
- Alcohol Consumption and Health Effects
- Genomics and Chromatin Dynamics
- Lung Cancer Treatments and Mutations
- Inflammatory Biomarkers in Disease Prognosis
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Tuberous Sclerosis Complex Research
- Cancer, Hypoxia, and Metabolism
- Cancer Risks and Factors
- Cardiovascular Function and Risk Factors
- RNA modifications and cancer
Shaoxing University
2023-2025
Cangzhou Central Hospital
2023-2024
Shaoxing People's Hospital
2023
Guangzhou Medical University
2020-2021
Guangzhou First People's Hospital
2020-2021
Nutrition and inflammation are closely related to prognosis in breast cancer patients. However, current nutritional inflammatory measures predict disease free survival (DFS) of still different, the most predictive remain unknown. This study aimed compare effects commonly used on DFS improve existing or order develop a new model that is more effective for predicting postoperative recurrence metastasis The clinical data 536 female patients with invasive ductal carcinoma who underwent surgery...
Neuron-specific enolase (NSE) has been used as a specific biomarker for small cell lung cancer (SCLC) patients. Nevertheless, the biological function and mechanism of NSE in SCLC are still unclear. In this study, we clarified role progression found that expression was positively correlated with distant metastasis. Functional analysis showed overexpression promoted migration invasion cells. Mechanism induced epithelial-mesenchymal transition (EMT) Moreover, increased protein β-catenin its...
Abstract Background The incidence of non‐alcohol fatty liver disease (NAFLD) has been increasing annually with the improvement living standards. Numerous epidemiological observations have linked sex hormone‐binding protein (SHBG) levels to NAFLD. However, evidence causal role SHBG in development and progression NAFLD is still absent. Therefore, a systematic assessment relationship needed. Method A two‐sample Mendelian randomisation (MR) analysis was conducted. Genome‐wide association study...
Abstract Bladder cancer is a prevalent malignancy with high mortality rates worldwide. Hypoxia critical factor in the development and progression of cancers. However, whether how hypoxia-related genes (HRGs) could affect chemotherapy response bladder still largely unexplored. This study comprehensively explored complex molecular landscape associated hypoxia by analyzing 260 based on transcriptomic genomic data 411 samples. Employing 109 dysregulated for consensus clustering, we delineated...
Abstract Disorders of mineral metabolism, including elevated levels serum calcium, phosphate, 25-hydroxyvitamin D (25OH-VitD), parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23), have been reported in patients with calcific aortic valve stenosis (CAVS). However, evidence the causal role metabolism CAVS is still lacking. In this study, we employed a systematic pipeline combining Mendelian randomization (MR), Steiger directionality test, colocalization analysis, protein-protein...
Triple-negative breast cancer (TNBC) is a clinically aggressive subtype of cancer. Core transcriptional regulatory circuitry (CRC) consists autoregulated transcription factors (TFs) and their enhancers, which dominate gene expression programs control cell fate. However, there limited knowledge CRC in TNBC. Herein, we systemically characterized the activated super-enhancers (SEs) interrogated 14 CRCs We found that could be broadly involved DNA conformation change, metabolism process,...
Objective To compare the efficacy of laparoscopic pancreaticoduodenectomy (LPD) and open (OPD) in a medium-volume medical center. Methods Data for patients who underwent OPD or LPD carcinoma ampulla Vater (VPC) between January 2017 June 2022 were acquired retrospectively. Propensity score-matching (PSM) analysis was performed to balance baseline characteristics groups. The primary outcome disease-free survival (DFS). Cox regression used explore independent risk factors DFS. Results A total...
Abstract Aim: Disorders of mineral metabolism, including elevated levels serum calcium, phosphate, 25-hydroxyvitamin D (25OH-VitD), parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23), have been reported in patients with calcific aortic valve stenosis (CAVS). However, evidence the causal role metabolism CAVS is still lacking. We aimed to investigate causality between CAVS. Methods: A systematic pipeline combining Mendelian randomization (MR), Steiger directionality test,...
Abstract Background Neuron-specific enolase (NSE) has been used as a specific biomarker for small cell lung cancer (SCLC) patients. Nevertheless, the biological function and mechanism of NSE in SCLC are still unclear. Methods We conducted an investigation patients then analyzed association between concentration distant metastasis. The migration invasion were using Wound-healing Transwell assays. proteins mRNA levels measured by western blot qRT-PCR. Furthermore, we Gene Set Enrichment...