A5024648038- Neuroscience and Neural Engineering
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Viral Infections and Outbreaks Research
- Disaster Response and Management
- Microfluidic and Bio-sensing Technologies
- Healthcare Systems and Public Health
Northwestern University
2024
Duke University
2023
Engineered heart tissues (EHTs) generated from human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) represent powerful platforms for cardiac research, especially in drug testing and disease modeling. Here, we report a flexible, three-dimensional electronic framework that enables real-time, spatiotemporal analysis of electrophysiologic mechanical signals EHTs under physiological loading conditions dynamic, noninvasive, longer-term assessments. These electromechanically...
Introduction: Our recent studies in non-human primates have demonstrated adeno-associated virus (AAV) delivery of prokaryotic sodium channel (BacNa v ) can improve the contractile function infarcted hearts. We hypothesized that BacNa expression increases cardiomyocyte (CM) by indirectly augmenting Ca 2+ transient amplitude via increase sarcoplasmic reticulum (SR) stores. Methods: developed an vitro model ischemia-reperfusion (I/R) injury engineered heart tissues (cardiopatches) made from...