A5015342193- Diabetes Management and Research
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular and exercise physiology
- Biochemical Analysis and Sensing Techniques
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Exercise and Physiological Responses
- Cardiovascular Function and Risk Factors
- Pharmacology and Obesity Treatment
- Growth Hormone and Insulin-like Growth Factors
- Liver Disease Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Blood Pressure and Hypertension Studies
- Retinal Diseases and Treatments
- Dietary Effects on Health
- Metabolism and Genetic Disorders
- Pregnancy and preeclampsia studies
Helsinki University Hospital
1993-2016
Eli Lilly (Switzerland)
2016
University of Helsinki
1991-2016
Eli Lilly (United States)
1998-2014
Eli Lilly (Germany)
2001-2012
Inserm
2001
Kätilöopisto Maternity Hospital
1999
Helsinki Children's Hospital
1999
Institute for Molecular Medicine Finland
1987-1999
Research Institute Hospital 12 de Octubre
1997
The serum levels of 34K insulin-like growth factor (IGF)-binding protein were measured by RIA in 88 type 1 diabetic patients, 9 patients with 2 diabetes, 7 insulinoma, 19 normal subjects (all after an overnight fast), and 82 a breakfast meal. In addition, the effect 2- to 3-h euglycemic steady state hyperinsulinemia on IGF-binding IGF-1 was studied some each fasted groups. Compared subjects, mean 4-fold (P less than 0.001) higher I treated conventional insulin injections, 2.5-fold those...
Insulin lispro, an insulin analog recently developed particularly for mealtime therapy, has a fast absorption rate and short duration of action. We compared lispro regular human in the treatment 1,008 patients with IDDM. The study was 6-month randomized multinational (17 countries) multicenter (102 investigators) clinical trial performed open-label crossover design. injected immediately before meal, 30–45 min meal. Throughout study, postprandial rise serum glucose significantly lower during...
Positron emission tomography permits noninvasive measurement of regional glucose uptake in vivo humans. We employed this technique to determine the effect FFA on leg, arm, and heart muscles. Six normal men were studied twice under euglycemic hyperinsulinemic (serum insulin approximately 500 pmol/liter) conditions, once during elevation serum by infusions heparin Intralipid 2.0 +/- 0.4 mmol/liter), infusion saline 0.1 0.01 mmol/liter). Regional rates measured using positron tomography-derived...
To examine the natural course of insulin action in Type I diabetes, we followed 15 patients prospectively for one year after diagnosis diabetes and also performed a cross-sectional study 53 additional who had 2 to 32 years. Two weeks diagnosis, rate glucose uptake during hyperinsulinemia, measure action, was percent lower with than 30 matched normal subjects (P<0.01), but it rose subsequent three months. At months 9 21 (43 percent) were clinical remission did not require therapy. In these...
To examine the effects of leg exercise on insulin absorption from various injection sites, 125I-labelled rapid actin (9 units) was injected subcutaneously into leg, arm or abdomen patients with insulin-dependent diabetes before one hour intermittent (bicycle) and a resting, control day. Insulin disappearance increased by 135 per cent during first 10 minutes (P less than 0.05) remained 50 above resting levels after 60 0.02). Leg had no effect arm, but reduced post-exercise recovery period As...
We examined the mechanisms of enhanced insulin sensitivity in 9 male healthy athletes (age, 25 +/- 1 yr; maximal aerobic power [VO2max], 57.6 1.0 ml/kg per min) as compared with 10 sedentary control subjects 28 2 VO2max, 44.1 2.3 min). In athletes, whole body glucose disposal (240-min clamp) was 32% (P < 0.01) and nonoxidative (indirect calorimetry) 62% higher than controls. Muscle glycogen content increased by 39% 0.05) but did not change controls during clamp. VO2max correlated (r = 0.60,...
We studied the effects of body composition and maximal aerobic power on insulin sensitivity in 23 normal-weight, healthy male subjects. Eight were weight lifters, eight long-distance runners, seven untrained controls. In each subject, percentage (BW) made up muscle fat tissue (% % fat, respectively), (O2max), to measured. The lifters characterized by 35% higher as compared with runners or controls (P &lt; 0.01). O2max was 30–40% than 0.001). During euglycemic clamp studies, similar...
We previously demonstrated that supraphysiological insulin concentrations reducedthe plasma 34K insulinlike growth factor-binding protein (IGF-BP) in humans. Inthis study we examined whether physiological changes regulateIGF-BP and, if so, the regulation is influenced by race, glucose tolerance, or rate of metabolism. For these purposes 1) analyzed relationship between fasting and IGF-BP 2 racial groups (23 Caucasians 35 southwestern American Indians), 2) measured response to oral 20 normal...
We studied the effect of physical training on in vivo tissue sensitivity to insulin and binding monocytes six previously untrained healthy adults. Physical (one hour cycle-ergometer exercise four times per week for weeks) failed alter body weight but resulted a 20 cent increase (P<0.02) maximal aerobic power (V̇O2 max) 30 (P<0.01) insulin-mediated glucose uptake (determined by clamp technique). The correlated directly with rise V̇O2 max (P<0.05). Binding [125I]insulin also rose 35 after...
It has recently been postulated that hyperglycemia per se may contribute to insulin resistance in diabetes. To examine this possibility directly, we measured glucose uptake after 24 h of (281 +/- 16 mg/dl) and normoglycemia (99 6 10 type I (insulin-dependent) diabetic patients (age 33 3 yr, relative body wt 102 3%) treated with continuous subcutaneous infusion. Hyperglycemia was induced by an intravenous infusion, whereas saline administered during the control day. During both studies...
The plasma growth hormone, epinephrine, and norephinephrine responses to cycle ergometer exercise (15 min at 1 W/kg) were examined in 10 juvenile-onset, insulin-dependent diabetics (ages 10–32 yr) during conventional insulin treatment after 7 14 days of with a portable subcutaneous infusion system that normalizes glucose. During (mean glucose, 205 ± 22 mg/dl), the hormone response was sevenfold greater than normal controls (P &lt; 0.01). After wk pump 89 3), fell 62% 0.001); by 2 had...
Leptin is an adipocyte-derived peptide hormone regulating energy balance in experimental animals.Although the physiological function of leptin humans still unclear, its secretion closely related to fat mass adult humans.To examine how fetal growth correlates with levels at birth, umbilical cord venous blood sample was obtained delivery from 50 term newborn infants.Twenty-eight infants had birth weights appropriate for gestational age (AGA; mean Ϯ SEM, 3362 90 g; relative weight, Ϫ0.08 0.2...
Many viral infections induce interferon (IFN) production and cause insulin resistance. To examine the causal relationship between IFN resistance, we injected natural human leukocyte IFN-alpha (3 x 10(6) IU, i.m.) twice overnight in eight healthy subjects determined oral (OGT) intravenous (IVGT) glucose tolerance sensitivity to (287 nmol or 40 mU.m-2.min-1 euglycemic clamp) following morning. caused mild influenzalike symptoms induced a rise circulating glucose, insulin, hydrocortisone...
The role of physical activity in the prevention non-insulin-dependent diabetes mellitus (NIDDM) is utmost importance. aim present study was to evaluate metabolic effects aerobic endurance exercise and circuit-type resistance training subjects with impaired glucose tolerance (IGT). Twenty-two individuals participated study. Fourteen were enrolled part study; seven exercised regularly for six months, while served as controls. Maximal capacity (VO2max) measured insulin sensitivity secretion...
Acute infections provoke insulin resistance. These experiments were designed to study the severity, duration, and mechanisms of resistance caused by acute infections. First, we studied eight patients [mean age, 29 ± 11 (±SD) yr; body mass index, 23 2 kg/m2] with viral or bacterial during stage their infection 1–3 months after recovery. The rate glucose infusion required maintain normoglycemia hyperinsulinemia (∼500 pmol/ L) was used as a measure action. During infection, requirements in [21...
We searched for metabolic crossover points in muscle glucose metabolite profiles during maintenance of matched fluxes across forearm insulin-resistant type I (insulin-dependent) diabetic patients and nondiabetic subjects. To classify subjects as insulin sensitive or resistant, whole-body disposal, oxidative nonoxidative disposal (indirect calorimetry), glycogen synthesis (muscle content needle biopsies) were measured under euglycemic conditions at two concentrations. Wholebody significantly...
To examine the effect of various carbohydrates on metabolic and hormonal response to exercise, 75 g glucose, fructose, or placebo were given nine well-trained males (VO2 max 60 +/- 1 ml . kg-1 min-1) 45 min before cycle ergometer exercise performed at 75% VO2 for 30 min. After glucose ingestion, rise in plasma was 3-fold (P less than 0.005) insulin 2.5-fold 0.01) greater after fructose. During administration fell from 5.3 0.3 2.5 0.2 mmol/l 0.001) fructose 4.5 0.1 3.9 0.05). The fall closely...
The influence of continuous sc insulin infusion therapy for 6 weeks on sensitivity to (euglycemic clamp technique) and hepatic glucose production (3-[3H]glucose was measured in 10 type 1 diabetic patients whose mean duration diabetes 8 yr. Mean diurnal blood fell from 8.5 ± 0.8 (SEM) mmol/liter 6.0 0.6 (P < 0.05) glycosylated hemoglobin 10.5 0.4% 8.7 0.3%. Insulin requirements declined by 23% 47 4 U/day prepump 36 2 after pump 0.01). During the clamp, plasma maintained at approximately 90...