A5081399807- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Genetics and Neurodevelopmental Disorders
- Glycosylation and Glycoproteins Research
- Telomeres, Telomerase, and Senescence
- Microbial Community Ecology and Physiology
- RNA modifications and cancer
- Methane Hydrates and Related Phenomena
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
Université de Sherbrooke
2023-2025
Matís (Iceland)
2022
Pseudogenes are mutated copies of protein-coding genes that cannot be translated into proteins, but a small subset pseudogenes has been detected at the protein level. Although ubiquitin represent one most abundant pseudogene families in many organisms, little is known about their expression and signaling potential. By re-analyzing public RNA-sequencing proteomics datasets, we here provide evidence for several including UBB 4 (UBBP4), which encodes UbKEKS (Q2K, K33E, Q49K, N60S). The...
To achieve replicative immortality, cancer cells must activate telomere maintenance mechanisms. In 10 to 15% of cancers, this is enabled by recombination-based alternative lengthening telomeres pathways (ALT). ALT display several hallmarks including heterogeneous length, extrachromosomal telomeric repeats, and ALT-associated PML bodies. also have high replication stress (RS) enhanced fork-stalling structures (R-loops G4s) altered chromatin states. cells, RS promotes elongation but above a...
<title>Abstract</title> Proliferating Cell Nuclear Antigen (PCNA) is a pivotal regulator of DNA replication and repair, orchestrating protein recruitment through its binding domains post-translational modifications (PTMs). Lysine 164 (K164) PCNA serves as critical molecular switch modulated by ubiquitin (Ub) ubiquitin-like proteins. Here, we identify the variant Ub<sup>KEKS</sup> new regulator, demonstrating covalent modification K164 quantifying Ub<sup>KEKS</sup>-to-Ub ratio. Loss results...
Ubiquitination is a post-translational modification responsible for one of the most complex multilayered communication and regulation systems in cell. Over past decades, new ubiquitin variants ubiquitin-like proteins arose to further enrich this mechanism. Recently discovered variant UbKEKS can specifically target several yet, functional consequences remain unknown. Depletion induces accumulation lamin A nucleoli, highlighting need deeper investigations about protein composition functions...
The oceanic crust is the world’s largest and least explored biosphere on Earth. basaltic subsurface of Surtsey island in Iceland represents an analog warm newly formed-oceanic offers a great opportunity for discovering novel microorganisms. In this study, we collected borehole fluids, drill cores, fumarole samples to evaluate culturable bacterial diversity from island. Enrichment cultures were performed using different conditions, media temperatures. A total 195 isolates successfully...
A bstract To achieve replicative immortality, cancer cells must activate telomere maintenance mechanisms. In 10-15% of cancers, this is enabled by recombination-based alternative lengthening telomeres pathways (ALT). ALT display several hallmarks including heterogeneous length, extrachromosomal telomeric repeats and ALT-associated PML bodies. also have high replication stress (RS) enhanced fork-stalling structures (R-loops, G4s) altered chromatin states. cells, RS promotes elongation but...
Abstract Ubiquitination is a post-translational modification responsible for one of the most complex multi-layered communication and regulation system in cell. Over past decades, new ubiquitin variants ubiquitin-like proteins arose to further enrich this mechanism. Among them, recently discovered variant Ub KEKS can specifically target several yet, functional consequences remain unknown. The absence induces accumulation lamin A nucleoli, highlighting need deeper investigations about protein...