A5029083197- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Proteins in Food Systems
- Microencapsulation and Drying Processes
- Advanced Drug Delivery Systems
- Pharmacological Effects of Natural Compounds
- Material Dynamics and Properties
- Advancements in Transdermal Drug Delivery
- Natural product bioactivities and synthesis
- Drug Transport and Resistance Mechanisms
- Material Science and Thermodynamics
- Food Chemistry and Fat Analysis
- Thermal and Kinetic Analysis
- Protein purification and stability
- Chemical synthesis and alkaloids
- Plant chemical constituents analysis
- Polysaccharides Composition and Applications
- Glass properties and applications
- Pain Mechanisms and Treatments
- Phytochemistry and Biological Activities
- Coconut Research and Applications
- Conducting polymers and applications
Uppsala University
2016-2024
International Islamic University Malaysia
2014-2019
We developed a step-by-step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and small-scale dissolution apparatus (μDISS Profiler) to investigate the mechanism (solid-to-solid or solution-mediated) by which crystallization of amorphous drugs occurs upon dissolution. This then guided how stabilize formulation. Indapamide, metolazone, glibenclamide glipizide were selected as model HPMC (Pharmacoat 606) PVP...
Advanced drug delivery systems (ADDS) are widely explored to overcome poor aqueous solubility of orally administered drugs. However, the prediction their in vivo performance is challenging, as vitro models typically do not capture interplay between processes occurring gut. In additions, different used evaluate systems. We therefore present a method that allows monitoring luminal processing (dissolution, digestion) and its with permeation better inform on absorption felodipine formulated...
This study shows the importance of chosen method for assessing glass-forming ability (GFA) and glass stability (GS) a drug compound. Traditionally, GFA GS are established using in situ melt-quenching differential scanning calorimeter. In this study, we included 26 structurally diverse drugs (i) to compare class when model were produced by spray-drying with that was used, (ii) investigate long-term physical resulting amorphous solids, (iii) relationship between physicochemical properties...
This study explores the effect of physical aging and/or crystallization on supersaturation potential and kinetics amorphous active pharmaceutical ingredients (APIs). Spray-dried, fully indapamide, metolazone, glibenclamide, hydrocortisone, hydrochlorothiazide, ketoconazole, sulfathiazole were used as model APIs. The parameters to assess maximum concentration (Cmax,app), area under curve (AUC), rate constant (k). These compared for freshly spray-dried aged/crystallized samples. Aged samples...