A5027989819- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Pancreatitis Pathology and Treatment
- Single-cell and spatial transcriptomics
- Cancer Immunotherapy and Biomarkers
- Cholesterol and Lipid Metabolism
- Hemoglobinopathies and Related Disorders
- Lipid Membrane Structure and Behavior
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related gene regulation
First Affiliated Hospital Zhejiang University
2023-2025
Ganzhou People's Hospital
2024
Nanchang University
2024
Zhejiang University
2022
Second Affiliated Hospital of Zhejiang University
2020
Objective Although N 6 -methyladenosine (m A) RNA methylation is the most common mRNA modification process, few studies have examined role of m A in stomach adenocarcinomas (STADs). Methods In this retrospective study, we analyzed 293 STAD samples from The Cancer Genome Atlas with complete clinicopathological feature profiles. risk signature was derived LASSO–Cox regression analyses 15 regulators. Statistical analysis performed and figures were prepared using R software (...
Cholesterol gallstone disease (CGD) is associated with bile cholesterol supersaturation. The Niemann-Pick C1-like 1 (NPC1L1), the inhibitory target of ezetimibe (EZE), a critical sterol transporter absorption. Intestinal NPC1L1 facilitates absorption cholesterol, whereas hepatic promotes uptake by hepatocytes and reduces potential to prevent CGD has yet be established due its absence in mice model. In this study, we generated expressing using adeno-associated virus (AAV) gene delivery....
Tumor-infiltrating lymphocytes (TILs) in gastric cancer are closely related to clinical prognosis; however, little is known regarding the immune microenvironment this disease. Thus, RNA-sequencing data from patients were downloaded Gene Expression Omnibus (GEO). The proportion of cells was determined based on a deconvolution algorithm (CIBERSORT), and gene expression profiles analyzed context outcomes construct an risk score. Data using least absolute shrinkage selection operator (LASSO)...
Cholesterol gallstone disease (CGD) is accompanied by biliary cholesterol supersaturation. Hepatic Niemann-Pick C1-like 1 (NPC1L1), which present in humans but not wild-type (WT) mice, promotes hepatocyte uptake and decreases In contrast, intestinal NPC1L1 absorption, increasing Ezetimibe (EZE) can inhibit both hepatic NPC1L1. However, whether affect CGD progress remains unknown.Mice expressing (NPC1L1hepatic-OE mice) were generated using Adeno-associated viruses (AAV) gene delivery. The...