A5075711138- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Metalloenzymes and iron-sulfur proteins
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
Boston Micromachines (United States)
2024
Ferroptosis, marked by iron-dependent lipid peroxidation, may present an Achilles heel for the treatment of cancers. Ferroptosis suppressor protein-1 (FSP1), as second ferroptosis mainstay, efficiently prevents peroxidation via NAD(P)H-dependent reduction quinones. Because its molecular mechanisms have remained obscure, we studied numerous FSP1 mutations in cancer or identified untargeted random mutagenesis. This mutational analysis elucidates FAD/NAD(P)H-binding site and proton-transfer...
Abstract The quest for novel targets breaking cancer therapeutic resistance has led to exciting efforts leverage ferroptosis specifically in cells, traditionally vulnerable iron-dependent lipid peroxidation 1 . In a recent paper published this venue, Mao et al. 2 introduced mitochondrially localized dihydroorotate dehydrogenase (DHODH) as an enzyme mediating tumor cells by reducing mitochondrial ubiquinone (CoQ 10 ), which turn facilitates scavenging of oxygen radicals membranes.