A5074574552- Nanoplatforms for cancer theranostics
- Phagocytosis and Immune Regulation
- Temporomandibular Joint Disorders
- Periodontal Regeneration and Treatments
- Osteoarthritis Treatment and Mechanisms
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Laser Applications in Dentistry and Medicine
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
University of California, Davis
2011-2019
Dual targeting to immune checkpoints has achieved a better therapeutic efficacy than single due synergistic extrication of tumour immunity. However, most dual strategies are usually antibody dependent which facing drawbacks antibodies, such as poor solid penetration and unsatisfied affinity. To meet the challenges, we engineered cell membrane displaying fusion protein composed SIRPα PD-1 variants, high-affinity consensus (HAC) wild-type molecules, with prepared nanovesicles (NVs). Through...
7559 Background: Consolidation chemotherapy following concurrent CRT may improve systemic control and possibly prolong survival of pt with stage III NSCLC. Phase II study using docetaxel showed promising result but subsequent phase was negative. We explored the role single agent gemcitabine (G) combination carboplatin (C) as consolidation chemotherapy. Methods: Study conducted by Asian mutli-center group. Eligible criteria: IIIA/B, histologic/cytologic confirmed NSCLC, completed according to...