A5004908593- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Reconstructive Surgery and Microvascular Techniques
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Orthopedic Infections and Treatments
- Dysphagia Assessment and Management
- Anesthesia and Pain Management
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- RNA modifications and cancer
- Diabetic Foot Ulcer Assessment and Management
- Opioid Use Disorder Treatment
- Gastrointestinal Tumor Research and Treatment
- Lower Extremity Biomechanics and Pathologies
- Surgical site infection prevention
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Hip and Femur Fractures
- Total Knee Arthroplasty Outcomes
- Aluminum Alloys Composites Properties
- Bone and Joint Diseases
- Musculoskeletal synovial abnormalities and treatments
- Aluminum Alloy Microstructure Properties
- Peripheral Nerve Disorders
Shanghai Sixth People's Hospital
2016-2025
Shanghai Jiao Tong University
2015-2025
Nanjing Forestry University
2025
Renji Hospital
2014-2025
Shanghai Cancer Institute
2025
Second Xiangya Hospital of Central South University
2013-2024
Central South University
2013-2024
University of Science and Technology Beijing
2024
Hunan Provincial Center for Disease Control and Prevention
2024
TIE Kinetix (Germany)
2024
Obesity is a risk factor for knee osteoarthritis (KOA) development and progression. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are indicated type 2 diabetes mellitus (T2DM) obesity. However, whether KOA patients can benefit from GLP-1RA therapies has not been sufficiently investigated, especially in the long term.The Shanghai Osteoarthritis Cohort study prospective, observational, multicentre of >40 000 adults with clinically diagnosed aged >45 years Shanghai. We identified all...
Abstract Background Colorectal cancer (CRC) is the most common digestive system malignancy. The molecular events involved in development and progression of CRC remain unclear. Recently, more evidences have showed that deregulated miRNAs participate colorectal carcinogenesis. Methods expression levels miR-138 were first examined cell lines tumor tissues by real-time PCR. vitro vivo functional effects further. Luciferase reporter assays conducted to confirm targeting associations. Kaplan-Meier...
Synergistic photodynamic therapy (PDT) that combines photosensitizers (PSs) to attack different key sites in cancer cells is very attractive. However, the use of multiple PSs may increase dark cytotoxicity. Additionally, realizing vein passage several through dosing could be a challenge clinical treatment. To address these issues, novel strategy enables single PS ablate two (i.e., cytomembranes on outside and mitochondria inside) synergistically was proposed. Five new fluorinated ruthenium...
To compare long-term occurrence of gastroesophageal reflux disease (GERD) between two different types peroral endoscopic myotomy (POEM) for achalasia.We included all patients with achalasia who underwent POEM at our hospital from August 2011 to October 2012 and had complete GERD evaluation ≥ 3 years follow-up. They were divided into circular or full-thickness groups according the depth myotomy. Demographics, Eckardt score, manometry results, 24-h pH monitoring, symptoms recorded compared...
An efficient method was developed that controls biscylometalated iridium(iii) complexes to target mitochondria or lysosomes by regulating the lipophilicity of main ligands.
Abstract Gastric cancer (GC) is a common type of tumor that characterized with high metastatic rate. In recent years, increasing studies have indicated lncRNAs are involved in the regulation on cell proliferation and migration. However, functional role long intergenic non-protein coding RNA 1559 (LINC01559) GC still unclear. this study, we applied quantitative real-time polymerase chain reaction (RT-qPCR) examined LINC01559 expression was significantly enhanced cells. Functional assays such...
The increasing societal concern for consumer information privacy has led to the enforcement of regulations worldwide. In an effort adhere such as General Data Protection Regulation (GDPR), many companies’ policies have become increasingly lengthy and complex. this study, we adopted computational design science paradigm a novel policy evolution analytics framework help identify how companies change present their based on regulations. includes Self-Attentive Annotation System (SAAS) that...
Autophagy participates in the progression of many diseases, comprising ischemia/ reperfusion (I/R). It is reported that it involved protective mechanism ischemic postconditioning (IPostC). According to research, neuronal nitric oxide synthase (nNOS) also condition I/R and IPostC. However, relationship between nNOS, autophagy IPostC has not been previously investigated. We hypothesize promotes activity against injury partially through nNOS-mediated pathways. Mouse hearts were subjected...
Gastric cancer (GC) is one of the most leading malignancies. Long noncoding RNA related to GC. In this study, 11 miRNAs in exosomes and six lncRNAs tissues was examined by qRT-PCR. Correlation analysis used analyze relationship between exosome tissues. Four level GC were MTT determine cell viability. Flow cytometry quantify apoptotic cells. Transwell assay examine migration invasion capacity. Dual-luciferase interaction HOTAIR miR-30a or -b. Capillary formation capillary Weak negative...
The pHs of extracellular fluids (ECFs) in normal tissues are commonly maintained at 7.35 to 7.45.The acidification the ECF is one major characteristics tumour microenvironment.In this study, we report that decreased pH promotes transformation mesenchymal stem cells (MSCs) into cancer-associated fibroblasts (CAFs), termed CAF activation.Furthermore, demonstrate GPR68, a proton-sensing G-protein-coupled receptor (GPCR), required for pH-dependent regulation differentiation MSCs CAFs.We then...
Purpose: To investigate the expression of histone deacetylase 6 (HDAC6) in colon cancer and its role cell growth migration. Materials methods: We detected HDAC6 a tissue chip using immunochemical staining, analyzed difference between adjacent noncancerous tissues. Then, we explored relationship patients' clinicopathological characteristics prognoses. In adidition, migration, as well potential related signal pathway, through knockdown was explored. Results: The score higher than (4.54 vs...
Methicillin-resistant Staphylococcus aureus (MRSA) can cause wound infections via a 'Trojan Horse' mechanism, in which neutrophils engulf intestinal MRSA and travel to the wound, releasing after apoptosis. The possible role of prosthetic joint infection (PJI) is unknown.Rats underwent colonization with green fluorescent protein (GFP)-tagged by gavage an intra-articular wire was then surgically implanted. After ten days, presence PJI determined bacterial cultures distal femur, capsule,...
Reprogramming lipid metabolism is considered a fundamental step in tumourigenesis that influences ferroptosis. However, molecular mechanisms between and ferroptosis remain largely unknown. Results from the drug screening of 464 inhibitors (for 164 targets) applied to cells indicated 4 targeted bromodomain-containing protein (BRD4) significantly inhibiting erastin-induced Functional studies proved loss BRD4 weakened oxidative catabolism mitochondria, protecting excessive accumulation...
Chronic ankle instability (CAI) is a common sequela following an acute lateral sprain (LAS). To treat LAS more effectively and efficiently, it important to identify patients at substantial risk for developing CAI. This study identifies magnetic resonance imaging (MRI) manifestations predicting CAI development after first episode of explores appropriate clinical indications ordering MRI scans these patients.All with first-episode who received plain radiograph scanning within the 2 weeks from...