A5089067662- Cancer Diagnosis and Treatment
- Bone health and treatments
- Receptor Mechanisms and Signaling
- Viral Infections and Immunology Research
- Genetic Syndromes and Imprinting
- Cancer and Skin Lesions
- Oral health in cancer treatment
- Liver Disease and Transplantation
- Cell Adhesion Molecules Research
- Heart Failure Treatment and Management
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Liver Disease Diagnosis and Treatment
- Bone and Joint Diseases
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
Novartis (United States)
2005-2017
Rural Development Administration
2003
The advent of bisphosphonates advanced therapy for Paget's disease, but more effective and convenient agents are needed to increase adherence. Zoledronic acid, a bisphosphonate administered as single intravenous infusion, might meet these needs.
A single 5-mg infusion of zoledronic acid restores biochemical markers bone turnover into the reference range in majority patients with Paget's disease and maintains remission for at least 2 years. This effect is largely independent pretreatment activity prior bisphosphonate therapy.Zoledronic (ZOL) a potent that produces rapid complete control increased disease. Long-term an important aim treatment hope this will reduce risk complications such as deformity, fracture, degenerative joint...
Background Chronic liver scarring from any cause leads to cirrhosis, portal hypertension, and a progressive decline in renal blood flow function. Extreme vasoconstriction characterizes hepatorenal syndrome, functional potentially reversible form of acute kidney injury patients with advanced but current therapy systemic vasoconstrictors is ineffective substantial proportion limited by ischemic adverse events. Serelaxin (recombinant human relaxin-2) peptide molecule anti-fibrotic...
Pregnancy block from exposure to foreign male mouse pheromones is sensitive both and female mating strain, as well the pheromone-producing strain. Incidence of pregnancy by in mice different depending on combination females, stud males stimulus males. BALB/cA females mated with showed a 100% when exposed DDK strain (Chung et al., 1997). In contrast, dissimilar show high rates even if they are males; this difference thought be due viability embryos 1999). The present study investigated how...