A5034313836- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Stress, Anesthesia, and Immune Response
- Musculoskeletal pain and rehabilitation
- Vitamin C and Antioxidants Research
- interferon and immune responses
- Vitamin D Research Studies
- Neurological diseases and metabolism
- Pain Management and Treatment
- Galectins and Cancer Biology
- Bone health and treatments
- Protein Tyrosine Phosphatases
- Pain Management and Opioid Use
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Cytokine Signaling Pathways and Interactions
- Neuroscience of respiration and sleep
- Diet and metabolism studies
- Fatty Acid Research and Health
- Heart Rate Variability and Autonomic Control
- Cancer Mechanisms and Therapy
- Sphingolipid Metabolism and Signaling
China Medical University
2019-2025
First Hospital of China Medical University
2019-2025
Duke University Hospital
2019-2021
Duke Medical Center
2019-2021
Duke University
2020-2021
Committee on Publication Ethics
2020
International Association for the Study of Pain
2020
Emerging immune therapy, such as with the anti–programmed cell death–1 (anti–PD-1) monoclonal antibody nivolumab, has shown efficacy in tumor suppression. Patients terminal cancer suffer from pain a result of bone metastasis and destruction, but how PD-1 blockade affects remains unknown. Here, we report that mice lacking Pdcd1 (Pd1−/−) demonstrated remarkable protection against destruction induced by femoral inoculation Lewis lung cells. Compared WT mice, Pd1−/− exhibited increased baseline...
Although sex dimorphism is increasingly recognized as an important factor in pain, female-specific pain signaling not well studied. Here we report that administration of IL-23 produces mechanical (mechanical allodynia) female but male mice, and chemotherapy-induced selectively impaired mice lacking Il23 or Il23r. IL-23-induced promoted by estrogen suppressed androgen, suggesting involvement hormones. requires C-fiber nociceptors TRPV1 to produce does directly activate nociceptor neurons....
Abstract Patients with advanced stage cancers frequently suffer from severe pain as a result of bone metastasis and destruction, for which there is no efficacious treatment. Here, using multiple mouse models cancer, we report that agonists the immune regulator STING (stimulator interferon genes) confer remarkable protection against cancer pain, local tumor burden. Repeated systemic administration robustly attenuates cancer-induced improves locomotor function. Interestingly, produce acute...
Earlier studies have demonstrated that essential fatty acid-derived specialized pro-resolving mediators (SPMs) promote the resolution of inflammation and pain. However, potential analgesic actions SPMs in chemotherapy-induced peripheral neuropathy (CIPN) are not known. Recent results also showed sex dimorphism immune cell signaling neuropathic Here, we evaluated D-series resolvins (RvD1, RvD2, RvD3, RvD4, RvD5) on a CIPN male female mice. Paclitaxel (PTX, 2 mg/kg), given days 0, 2, 4, 6,...
Abstract GPR37 was discovered more than two decades ago, but its biological functions remain poorly understood. Here we report a protective role of in multiple models infection and sepsis. Mice lacking Gpr37 exhibited increased death and/or hypothermia following challenge by lipopolysaccharide (LPS), Listeria bacteria, the mouse malaria parasite Plasmodium berghei . Sepsis induced LPS wild-type mice is protected artesunate (ARU) neuroprotectin D1 (NPD1), actions these agents are lost −/−...
Abstract Background Neuropathic pain (NP) is a kind of intractable pain. The pathogenesis NP remains complicated issue for management practitioners. SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2 (SPOCK2) are members the SPOCK family that play significant role in development central nervous system. In this study, we investigated SPOCK2 rat model chronic constriction injury (CCI). Methods Sprague–Dawley rats were randomly grouped to establish CCI models. We examined effects on...
Neuropathic pain (NP) is chronic and associated with poor effects of general analgesia. It affects patients' health quality life. The apoptotic process lipid peroxidation caused by iron overload called ferroptosis, which may be nervous system disease. A recent study has found that sirtuin 2 (SIRT2) achieves a neuroprotective effect suppressing ferroptosis. Herein, we aimed to examine whether SIRT2 regulated spared nerve injury (SNI)-induced NP ferroptosis in rats. rat model was induced adult...
Neuropathic pain is a complex condition that usually lasts lifetime and has major negative impact on life after injury. Improving management an important unmet need. Astaxanthin (AST) natural marine medicine with effective antioxidant anti-inflammatory properties neuroprotective effects. However, few mechanisms can explain the role of AST in treatment neuropathic pain. In present study, we examined its potential to eliminate spinal nerve ligation (SNL) damage by inhibiting phosphorylation...
Neuropathic pain, a chronic condition with high incidence, imposes psychological burdens on both patients and society. It is urgent to improve pain management develop new analgesic drugs. Traditional Chinese medicine has gained popularity as method for relief. Diosmetin (Dio) mainly found in herbal medicines effective antioxidant, anti-cancer, anti-inflammatory properties. There are few known mechanisms underlying the effectiveness of Dio treating neuropathic pain. However, complete...
The immune checkpoint inhibitor programmed cell death protein 1 (PD-1) plays a critical role in regulation. Recent studies have demonstrated functional PD-1 expression peripheral sensory neurons, which contributes to neuronal excitability, pain, and opioid analgesia. Here we report function of the central nervous system (CNS), including spinal cord, thalamus, cerebral cortex. Notably, GABA-induced currents dorsal horn thalamic cortical neurons are suppressed by PD-1-neutralizing...
Mounting evidence from animal models of inflammatory and neuropathic pain suggests that inflammation regulates the resolution by producing specialized pro-resolving mediators (SPMs), such as resolvin D1 (RvD1). However, it remains unclear how SPMs are induced in central nervous system whether these mechanisms can be reconciled with outcomes neuromodulation therapies for pain, spinal cord stimulation. Here, we show a male rat model produced spared nerve injury (SNI), 1 kHz stimulation (1 SCS)...
Reduction in Nrf2-mediated antioxidant response the central nervous system plays an important role development and maintenance of neuropathic pain (NP). However, mechanisms regulating Nrf2 activity NP remain unclear. A recent vitro study revealed that Sirt2, a member sirtuin family proteins, affects capacity by modulating activity. Here we examined whether Sirt2 regulates through oxidative stress pathway. In rat model spared nerve injury (SNI)-induced NP, mechanical allodynia thermal...
BACKGROUND: Spinal cord stimulation (SCS) is an emerging, minimally invasive procedure used to treat patients with intractable chronic pain conditions. Although several signaling pathways have been proposed account for SCS-mediated relief, the precise mechanisms remain poorly understood. Recent evidence reveals that injured sensory neuron-derived colony-stimulating factor 1 (CSF1) induces microglial activation in spinal cord, contributing development of neuropathic (NP). Here, we tested...
Obesity is associated with increased sensitivity to pain, including neuropathic but the precise mechanisms are not fully understood. Recent evidence has revealed that AMP‑activated protein kinase (AMPK) in central nervous system (CNS) regulates neuropeptide calcitonin gene‑related peptide (CGRP), a principal neurotransmitter of class C nerve fiber, which serves an important role initiating and maintaining pain. AMPK been demonstrated be downregulated CNS obesity. The present study...
Background Voltage-gated sodium channel Nav1.7 has been validated as a perspective target for selective inhibitors with analgesic and anti-itch activity. The objective of this study was to discover new candidate compounds inhibitor properties. authors hypothesized that their approach would yield at least one compound inhibits currents in vitro exerts effects mice. Methods In silico structure-based similarity search 1.5 million followed by docking the voltage sensor Domain 4 molecular...
Inflammatory pain is a complex process that has substantial negative impact on post-injury quality of life. Astaxanthin (AST), which lipid-soluble red-orange carotenoid found in lobsters, inhibits the development and maintenance inflammation mice via its antioxidant anti-inflammatory activities. However, specific mechanisms underlying these effects remain unclear. In this study, we aimed to elucidate mechanism by astaxanthin alleviated using mouse model with Complete Freund's adjuvant...
Background Pain is a complex perception involving unpleasant somatosensory and emotional experiences. However, the underlying mechanisms that mediate its different components remain unclear. Sphingosine-1-phosphate (S1P), metabolite of sphingomyelin potent lipid mediator, initiates signaling via G protein-coupled receptors (S1PRs) on cell surfaces. It serves as second messenger in cellular processes such proliferation apoptosis. Nevertheless, neuropharmacology sphingolipid pain conditions...
Abstract Agonists of the innate immune regulator stimulator interferon genes (STING) have shown great efficacy in promoting antitumor immunity preclinical models, leading to their exploration cancer immunotherapy trials. Patients with advanced stage cancers frequently suffer from severe pain as a result bone metastasis and destruction, for which there is no efficacious treatment. Here, using multiple mouse models metastatic cancer, we report that STING agonists confer remarkable protection...