A5034863838- Atherosclerosis and Cardiovascular Diseases
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Advanced biosensing and bioanalysis techniques
- Skin Protection and Aging
- Periodontal Regeneration and Treatments
- Nanoparticle-Based Drug Delivery
- Toxoplasma gondii Research Studies
- Cardiovascular Disease and Adiposity
- Galectins and Cancer Biology
- Toxin Mechanisms and Immunotoxins
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Adipokines, Inflammation, and Metabolic Diseases
- Nanopore and Nanochannel Transport Studies
- Wound Healing and Treatments
- Inflammasome and immune disorders
- Hemostasis and retained surgical items
- Photoacoustic and Ultrasonic Imaging
- Sexual function and dysfunction studies
- Chemokine receptors and signaling
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Genital Health and Disease
- Cutaneous lymphoproliferative disorders research
- Oral and gingival health research
University of Glasgow
2019-2025
Brazilian Center for Research in Energy and Materials
2022-2024
Brazilian Biosciences National Laboratory
2022-2024
Universidade Estadual de Campinas (UNICAMP)
2018-2022
To synthesize HER2 aptamer-conjugated iron oxide nanoparticles with a coating of poly(2-(dimethylamino) ethyl methacrylate)-poly(2-methacryloyloxyethylphosphorylcholine) block copolymer (IONPPPs).
T-cell receptor recognition of cognate peptide–MHC leads to the formation signalling domains and immunological synapse. Because close membrane apposition, there is rapid exclusion CD45, therefore LCK activation. Much less known about whether spatial regulation intracellular face dictates activity TCR signal transduction. Moreover, as a driver in T acute lymphocytic leukaemia, it important understand its regulation. Here, we demonstrate direct role ciliary protein UNC119 trafficking...
Aims: To compare levels and activity of the growth factors between fresh lyophilized platelet-rich plasma (PRP). Methods: Analysis platelet concentration using fibroblast human umbilical vein endothelial cell cultures were compared PRP obtained from peripheral blood. Results: After lyophilization, 54% platelets intact whereas showed no aggregation with agonists (levels under 20%). The (VEGF, EGF, TGF-β PDGF) in both products similar. Fresh PRPs induced proliferation fibroblasts at 24 h...
Abstract Background and Purpose Hypertension is a multifactorial disease, manifested by vascular dysfunction, increased superoxide production, perivascular inflammation. In this study, we have hypothesized that 1,2,3,4,6‐penta‐ O ‐galloyl‐β‐ d ‐glucose (PGG) would inhibit inflammation protect from dysfunction in an experimental model of hypertension. Experimental Approach PGG was administered to mice every 2 days at dose 10 mg·kg −1 i.p during 14 Ang II infusion. It used final concentration...
To report a near-fatal poisoning after intentional injection of ricin from castor bean (Ricinus communis) extract.A 21 year-old man self-injected ∼3 mL extract intramuscularly and subcutaneously in the left antecubital fossa. Upon admission to our ED (1 h post-exposure; day 1, D1) he was awake alert, but complained mild local pain showed slight edema erythema. He evolved refractory shock (∼24 post-exposure) that required administration large volume fluids high doses norepinephrine...
Infections caused by fungi are prominent in our environment and can be potentially fatal. Paracoccidioidomycosis (PCM), of the Paracoccidioides genus, is most frequent systemic mycosis Brazil main cause death among immunocompetent individuals. The antifungal therapy for PCM usually effective but side effects relapses often reported. latter could avoided with alternative or complementary therapies aimed at boosting immune response to combat this pathogen. Recent reports have pointed...
Interleukin-27, a cytokine of the IL-12 family, is secreted by antigen-presenting cells such as macrophages and dendritic (DCs). Recent studies suggest an anti-inflammatory role for IL-27 inducing IL-10 producing Tr1 capable inhibiting Th1 Th17 type responses. Our study aimed to investigate involvement in immunomodulation paracoccidioidomycosis (PCM), most prevalent systemic mycosis Brazil. The presence was evaluated serum biopsies patients with PCM ELISA, immunohistochemistry,...
Abstract Hybrid nanoparticles have shown promise in biomedical applications; however, their seamless integration into clinical settings remains challenging. Here, we introduce a novel metal oxide polymer hybrid nanoparticle (NP) with high affinity for nucleic acids. Iron (IONP) were initially synthesized via the co-precipitation method and subjected to comprehensive characterization. Subsequently, block copolymers using Reversible Addition−Fragmentation Chain Transfer (RAFT) technique,...
Objective: Hypertension (HT) is associated with perivascular adipose tissue (PVAT) inflammation in which chemokines play a crucial role. Atypical chemokine receptor 2 (ACKR2) essential for CC-chemokine ligand binding and their degradation resulting regulation of inflammation. We hypothesized that ACKR2 important immune cell recruitment into PVAT. Design method: Using flow cytometry we analysed the numbers leukocytes infiltrating PVAT ACKR2-/- mice WT (wild-type, C57BL/6J) infused 14 days Ang...
Background: Platelet-rich plasma (PRP) has a high concentration of growth factors (GFs), which present therapeutic wound healing effect. Despite having been correlated with an immunomodulatory function, the administration PRP not yet investigated in atherosclerosis models. Aim: Evaluate effect lyophilized on mice models through serum analysis. Methods: Animals received high-fat diet for disease induction and weekly retro-orbital application. Effectiveness was evaluated by measuring...
Abstract Ultraviolet C (UVC) light has long been used as a sterilizing agent, primarily through devices that emit at 254 nm. Depending on the dose and duration of exposure, UV nm can cause erythema photokeratitis potentially skin cancer since it directly modifies nitrogenated nucleic acid bases. Filtered KrCl excimer lamps (emitting mainly 222 nm) have emerged safer germicidal tools even proposed to sterilize surgical wounds. All studies showed safety analyzed cell number viability,...
Aim: We aimed to verify the frequency of CD8+ T cell subsets in patients with acute form and chronic paracoccidioidomycosis. Material & Methods: Mononuclear cells from paracoccidioidomycosis healthy donors were isolated phenotyped by flow cytometry. Dendritic pulsed Paracoccidioides brasiliensis yeast co-cultures lymphocytes. Cytokine production was measured ELISA. Results: Acute present a higher Tc1 Tc10 cells, while have more Tc21 compared controls. In vitro assays showed that P. induced...