The cardiovascular effects and pharmacokinetics of once-daily enalapril were studied after single-dose subchronic treatment in eight patients with hypertension by use ambulatory blood pressure monitoring. Enalapril, 10 mg, was given at either 7 AM or PM a randomized crossover design. In addition, inhibition serum converting enzyme studied. Subchronic am significantly reduced during the day but less effective night. dosing pm further decreased nighttime followed slow increase day, no effect...

Fatalities or cardiovascular side effects of vaccines were rather uncommon in the past. So far, numerous reports and deaths associated with Covid-19 vaccination have been accepted behind background pandemic situation priority vaccinated elderly population at beginning vaqccination campaign. Cardiac heart circulatory disturbances resp. application not recognized up to now exception thrombotic/embolic cases myo-/pericarditis. But mechanism action suggests that downregulation ACE2 by...

SARS-CoV-2 spike interactions with the renin-angiotensin-aldosterone system-Consequences of adverse reactions vaccination-Abstract:The protective angiotensin-converting enzyme 2 (ACE2) – essential part system (RAAS) - is target receptor for its physiological ligands angiotensin I and II (Ang I/II) as well SARS-CoViruses -spikes. It mediates Ang degradation precondition SARS-CoVirus cell entry, spike-induced reactions, cytotoxic fusion. In ACE2 downregulation, reduced consequence increasing...

Effects of lithium and tetrahydroaminoacridine (THA), either alone or in combination, were tested an animal model excitotoxic cholinergic deafferentation the cerebral cortex. Rats received ibotenic acid lesions basal forebrain nuclei resulting a 30 % to 40 depletion both cortical choline acetyltransferase (ChAT) acetylcholinesterase (AChE) activity. Lithium as well THA, given separately prior subsequently development lesion, had small but significant effects on recovery ChAT AChE Applied...

This review/analysis gives a first impression of numerous adverse events related to Covid-19 vaccination, whichhave received little attention date, are often unexplained, but nevertheless very distressing. Frequentlyobserved organ-related ADRs after vaccination were such the nervous system, musculoskeletal system,gastrointestinal tract, and skin.The involvement almost all organs in side effect spectrum vaccines demonstrates their systemicefficacy. As shown by occurrence even days weeks,...

Using a single dose carcinogen model developed in the rat (Moore et al., Carcinogenesis 8, 483, 1987), we have examined effects of either phenobarbital (PB) or/and buthionine sulfoximine (BSO) pretreatment male Fischer rats on aflatoxin B1 (AFB1)-induced glutathione S-transferase placental form (GST-P) positive hepatocytes detected by immunohistochemical method. Control 48 hr. after i.p. administration AFB1 (2 mg/kg body wt.) yielded about 10.1 ± 4.8 GST-P hepatocytes/sq. cm.; PB inhibited...

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study

Aims: The aim of this investigation was to determine whether the global and cardiovascular 10 burden associated with spike-based Covid-19 vaccination has continued increase. 11Methods results: An updated analysis spontaneously reported individual cases 12 ADRs their fatal outcomes vaccines, as well adverse 13 events caused by spike-inducing vaccine Tozinameran, performed. 14Data were retrieved from EudraVigilance web reports European Medicines Agency 15 (EMA). All evaluated correspond search...

Abstract:Knowledge about the efficacy of vaccine spikes has multiplied in recent years.The purpose this review is to update key findings from scientific literature that provide explanations for many reported and analysed adverse effects associated with spike-based Covid-19 vaccination.Principle results: An overwhelming body evidence supports main mode action vaccines, namely downregulation ACE2 by spikes. Direct spike effects, synergisms RAAS-independent responses complement multiply already...

The aim of this review is to provide explanations for many the reported adverse reactions associated with spike-based Covid-19 vaccination and draw appropriate conclusions. Based on comparatively disproportionate spectrum vaccines, an overwhelming body evidence supports consequences main mode action namely downregulation angiotensin-converting enzyme 2 (ACE2) by spikes. This a key protective counterregulator in renin-angiotensin-aldosterone system. system not only responsible cardiovascular...

Abstract Acute myocardial infarction (AMI) leads to left ventricular dysfunction, the extent of which predicts mortality. We studied effect very early enalapril treatment in patients with failure (Killip classification II‐III) resulting from AMI. In a double‐blind randomized trial, on conventional were started placebo (PL, n = 15) or 2.5 mg (EN, twice daily as 24 30 h after AMI and followed up over period 21 days. One patient died each group. There three dropouts group (progressive heart...