A5068680303- Adenosine and Purinergic Signaling
- Zebrafish Biomedical Research Applications
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Environmental Toxicology and Ecotoxicology
- Neuroinflammation and Neurodegeneration Mechanisms
- Fish Ecology and Management Studies
- Neuroendocrine regulation and behavior
- Pharmacological Effects and Toxicity Studies
- Receptor Mechanisms and Signaling
- Neonatal Health and Biochemistry
- Cholinesterase and Neurodegenerative Diseases
- Physiological and biochemical adaptations
- Metabolism and Genetic Disorders
- Bipolar Disorder and Treatment
- Reproductive tract infections research
- Mitochondrial Function and Pathology
- Prenatal Substance Exposure Effects
- RNA Interference and Gene Delivery
- Aquaculture Nutrition and Growth
- Folate and B Vitamins Research
- Neurotransmitter Receptor Influence on Behavior
- Adolescent Sexual and Reproductive Health
- Calcium signaling and nucleotide metabolism
- Epilepsy research and treatment
Pontifícia Universidade Católica do Rio Grande do Sul
2016-2025
Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais
2019-2024
Xi'an Jiaotong University
2022
National Council for Scientific and Technological Development
2018
Instituto Nacional de Ciência e Tecnologia Translacional em Medicina
2010-2017
Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional
2015
National Institute on Population Medical Genetics
2010-2011
University of Buenos Aires
2005
Universidade Federal do Rio Grande do Sul
1997-2004
Colciencias
2003
There is growing interest in zebrafish as a model organism behavioral pharmacology research. Several anxiety behaviors have been characterized zebrafish, but the effect of anxiolytic drugs on these parameters has scarcely studied. The purpose this work was to assess predictive validity acute treatment with anxiety. In first task we simultaneously observed behavior adult four parameters: height tank, locomotion, color, and shoal cohesion. second assessment light/dark preference for 5 min....
Pollution is a world problem with immeasurable consequences. Heavy metal compounds are frequently found as components of anthropogenic pollution. Here we evaluated the effects treatment cadmium acetate, lead mercury chloride, and zinc chloride in acetylcholinesterase activity gene expression pattern, well these treatments antioxidant competence brain an aquatic well-established organism for toxicological analysis, zebrafish (Danio rerio, Cyprinidae). Mercury acetate promoted significant...
The open tank paradigm, also known as novel diving test, is a protocol used to evaluate the zebrafish behavior. Several characteristics have been described for this species, including scototaxis, which natural preference dark environments in detriment of bright ones. However, there no evidence regarding influence “natural stimuli” subjected novelty-based paradigms. In report, we evaluated spatio-temporal exploratory activity short-fin phenotype after short-period confinement into dark/bright...
Glyphosate has become the most widely used herbicide in world, due to wide scale adoption of transgenic glyphosate resistant crops after its introduction 1996. may be alone, but it is commonly applied as an active ingredient Roundup®. This pesticide contains several adjuvants, which promote unknown toxicity. The indiscriminate application poses numerous problems, both for health applicators and consumers, environment, contaminating soil, water leading death plants animals. Zebrafish (Danio...
Chronic stress may cause physical, behavioral and neuropsychiatric changes, affecting the health condition of an individual. Aggression is a universal behavior with great relevance on human animal social systems. Despite studies showing influence chronic aggression, effects unpredictable (UCS) aggressive in male female zebrafish remain unknown. Thus, aim this study was to evaluate UCS cortisol levels adult both sexes. Our results showed that increased aggression males, but not females, which...
Diabetes mellitus (DM) affects over 10% of the world's population. Hyperglycemia is main feature for diagnosis this disease. The zebrafish (Danio rerio) an established model organism study various metabolic diseases. In paper, hyperglycemic zebrafish, when immersed in a 111 mM glucose solution 14 days, developed increased glycation proteins from eyes, decreased mRNA levels insulin receptors muscle, and reversion high blood level after treatment with anti-diabetic drugs (glimepiride...
Endosulfan is a broad spectrum organochlorine pesticide that still widely in use many developing countries. Following application, endosulfan can get to watercourses through surface runoff from agricultural fields and disturb the non-target aquatic animals including freshwater fish species. Given activity of enzyme acetylcholinesterase (AChE) one most recurrently used biomarkers exposure pesticides there are controversial results concerning effects AChE fish, aim present study was evaluate...
In this study, we evaluated the effects of tebuconazole on morphology and exploratory larvae behavior adult locomotion. Furthermore, analyzed fungicide AChE activity gene expression in zebrafish brain. Tebuconazole (4 mg/L) increased ocular distance reduced travelled, absolute turn angle, line crossing time outside area exposed larvae. Moreover, that were to 6 showed a decrease travelled mean speed when compared control group. However, did not alter number crossings or spent upper zone....
The aim of this study was to analyze if the pre-administration anthocyanin on memory and anxiety prevented effects caused by intracerebroventricular streptozotocin (icv-STZ) administration-induced sporadic dementia Alzheimer's type (SDAT) in rats. Moreover, we evaluated whether levels nitrite/nitrate (NOx), Na+,K+-ATPase, Ca2 +-ATPase acethylcholinesterase (AChE) activities cerebral cortex (CC) hippocampus (HC) are altered experimental SDAT. Male Wistar rats were divided 4 different groups:...
In teleosts, changes in swimming, exploring, general locomotor activity, and anxious state can be a response to stress mediated by the corticotropin-releasing hormone system activation its effects on glucocorticoid levels. Zebrafish has been widely used study neuropharmacology become promising animal model investigate neurobehavioral mechanisms of stress. this report animals were submitted acute restraint for different time lengths (15, 60 90 min) further evaluation behavioral patterns,...
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with no effective treatment and commonly diagnosed only on late stages. Amyloid-β (Aβ) accumulation exacerbated tau phosphorylation are molecular hallmarks of AD implicated in cognitive deficits synaptic neuronal loss. The Aβ connection beginning to be elucidated attributed interaction different components common signaling pathways. Recent evidences suggest that non-fibrillary forms bind membrane receptors modulate GSK-3β...
Chronic exposure to paraquat (Pq), a toxic herbicide, can result in Parkinsonian symptoms. This study evaluated the effect of systemic administration Pq on locomotion, learning and memory, social interaction, tyrosine hydroxylase (TH) expression, dopamine 3,4-dihydroxyphenylacetic acid (DOPAC) levels, transporter (DAT) gene expression zebrafish. Adult zebrafish received an i.p. injection either 10 mg/kg (Pq10) or 20 (Pq20) every 3 days for total six injections. Locomotion distance traveled...