A5032797026- RNA Research and Splicing
- Neurobiology and Insect Physiology Research
- Cellular transport and secretion
- Tactile and Sensory Interactions
- RNA and protein synthesis mechanisms
- Transcranial Magnetic Stimulation Studies
- Ubiquitin and proteasome pathways
- Muscle activation and electromyography studies
- Advanced Fluorescence Microscopy Techniques
University of Oxford
2022-2023
While post-transcriptional control is thought to be required at the periphery of neurons and glia, its extent unclear. Here, we investigate systematically spatial distribution expression mRNA single molecule sensitivity their corresponding proteins 200 YFP trap lines across intact Drosophila nervous system. 97.5% genes studied showed discordance between they encode in least one region These data suggest that regulation very common, helping explain complexity We also discovered 68.5% these...
Freezing of gait (FOG) is a common occurrence in patients with Parkinson's disease (PD) that leads to significant limitations mobility and increases risk falls. Focused vibrotactile stimulation cueing are two methods used alleviate motor symptoms, including FOG, PD. While effective on their own, the effect combining both focused has yet be investigated. Two patients, history PD, suffered from frequent FOG episodes failed respond adequately medication. A novel device delivered rhythmic...
Summary While post-transcriptional control is thought to be required at the periphery of neurons and glia, its extent unclear. Here, we investigate systematically spatial distribution expression mRNA single molecule sensitivity their corresponding proteins 200 YFP trap protein lines across intact Drosophila nervous system. 98% genes studied showed discordance between they encode in least one region These data suggest that regulation very common, helping explain complexity We also discovered...