A5063868445- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Ischemia and Reperfusion
- Cardiac Valve Diseases and Treatments
- Receptor Mechanisms and Signaling
- Cardiac pacing and defibrillation studies
- Mitochondrial Function and Pathology
- Cardiovascular Issues in Pregnancy
- Heart Failure Treatment and Management
- Infective Endocarditis Diagnosis and Management
- Cardiac tumors and thrombi
- Signaling Pathways in Disease
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- Electron Spin Resonance Studies
- Neuroblastoma Research and Treatments
- Aortic aneurysm repair treatments
- Neurofibromatosis and Schwannoma Cases
- Connective tissue disorders research
- Hip disorders and treatments
- Antimicrobial Resistance in Staphylococcus
- Aortic Thrombus and Embolism
Yamaguchi University
2013-2022
Gifu University
2004-2020
Tokuyama (Japan)
2013-2018
Japan Community Healthcare Organization
2018
Shizuoka Medical Center
2006-2008
Abstract Cardiac hypertrophy is a well-known major risk factor for poor prognosis in patients with cardiovascular diseases. Dysregulation of intracellular Ca 2+ involved the pathogenesis cardiac hypertrophy. However, precise mechanism underlying remains elusive. Here, we investigate whether pressure-overload induced can be by destabilization ryanodine receptor (RyR2) through calmodulin (CaM) dissociation and subsequent leakage, it genetically rescued enhancing binding affinity CaM to RyR2....
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by a single point mutation in the cardiac type 2 ryanodine receptor (RyR2). Using knockin (KI) mouse model (R2474S/+), we previously reported that within RyR2 sensitizes channel to agonists, primarily mediated defective interdomain interaction and subsequent dissociation of calmodulin (CaM) from RyR2. Here, examined whether CPVT can be genetically rescued enhancing binding affinity CaM We first determined there possible...
AimsThe channel function of the cardiac ryanodine receptor (RyR2) is modulated by calmodulin (CaM). However, involvement CaM in aberrant Ca2+ release diseased hearts remains unclear. Here, we investigated pathogenic role defective binding to RyR2 dysfunction associated with heart failure.
Abstract Aims Data regarding prognostic events following catheter ablation (CA) for atrial fibrillation (AF) in patients with heart failure preserved ejection fraction (HFpEF) are scarce. We conducted this study to compare the incidence of major adverse clinical (MACE) CA AF between HFpEF and those systolic (HF). Methods results This single‐centre observational included 142 HF who underwent (median follow‐up: 4.0 [2.6, 6.3] years). The were grouped based on presence ( n = 84) (left...
Objectives The purpose of this study was to investigate whether adding a low-dose β1-blocker milrinone improves cardiac function in failing cardiomyocytes and the underlying cardioprotective mechanism. Background molecular mechanism how combination affects intracellular Ca2+ handling heart failure remains unclear. Methods We investigated effect plus landiolol on transient (CaT), cell shortening (CS), frequency diastolic sparks (CaSF), sarcoplasmic reticulum concentration ({Ca2+}SR) normal...
Abstract Background The efficacy of prophylactic coronary revascularization with percutaneous intervention (PCI) or artery bypass graft (CABG) surgery in patients abdominal aortic aneurysm (AAA) scheduled for open repair remains controversial. Hypothesis Concomitant disease (CAD) no inducible ischemia can be medically treated AAA undergoing as long the existence CAD is recognized. Method A retrospective analysis acute and long‐term outcomes was performed 122 who underwent arteriography (CAG)...
Catecholamines induce intracellular reactive oxygen species (ROS), thus enhancing diastolic Ca2+ leakage through the ryanodine receptor during heart failure (HF). However, little is known regarding effect of atrial natriuretic peptide (ANP) on ROS generation and handling in failing cardiomyocytes. The aim present study was to clarify mechanism by which an exogenous ANP exerts cardioprotective effects HF. Cardiomyocytes were isolated from left ventricles a canine tachycardia-induced HF model...
Background Catheter ablation can improve long-term prognosis of patients with atrial fibrillation systolic impairment. However, tachyarrhythmia (ATA) recurrence increases during follow-up. We aimed to investigate the impact ATA on development adverse clinical events following catheter for and identify predictors events. Methods Results This single-center observational study included 75 impairment (left ventricular ejection fraction <50%) who underwent first procedure at our institution...
Long-duration atrial high-rate episodes (AHREs) monitored using cardiac implantable electronic devices (CIEDs) can predict long-term major adverse cardiovascular events (MACEs). This study aimed to compare the impact of long-duration AHRE on MACE development between patients with and without a history fibrillation (AF). single-center observational included 132 CIED-implanted AHREs detected via remote monitoring. The population was dichotomized into groups: (n = 69) 63) AF. In each group,...