A5040291964- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Autism Spectrum Disorder Research
- Neurogenesis and neuroplasticity mechanisms
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Stress Responses and Cortisol
- Nuclear Receptors and Signaling
- Microtubule and mitosis dynamics
- Attention Deficit Hyperactivity Disorder
- Memory and Neural Mechanisms
- Computational Drug Discovery Methods
- Congenital heart defects research
- Genomics and Chromatin Dynamics
- Cellular transport and secretion
- Receptor Mechanisms and Signaling
- Pancreatic function and diabetes
- Adenosine and Purinergic Signaling
- Photoreceptor and optogenetics research
- Epigenetics and DNA Methylation
- Mental Health Research Topics
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
Yonsei University
2019-2025
Severance Hospital
2023
Institute for Basic Science
2015-2021
Korea Advanced Institute of Science and Technology
2015
Although the medial prefrontal cortex (mPFC) is known to play a crucial role in rodent social behavior, little about mPFC neural correlates of behavior. In present study, we examined single-neuron activity mice performing modified version three-chamber test. We found that subset neurons elevate discharge rates when approaching stranger mouse but not an inanimate object or empty chamber. Our results reveal correlated with approach behavior widely used social-interaction paradigm. These...
Abstract Motivation Efficient assessment of the blood–brain barrier (BBB) penetration ability a drug compound is one major hurdles in central nervous system discovery since experimental methods are costly and time-consuming. To advance elevate success rate neurotherapeutic discovery, it essential to develop an accurate computational quantitative model determine absolute logBB value (a logarithmic ratio concentration brain its blood) candidate. Results Here, we developed (LogBB_Pred) capable...
Shank2 is an excitatory postsynaptic scaffolding protein implicated in synaptic regulation and psychiatric disorders including autism spectrum disorders. Conventional -mutant ( −/− ) mice display several autistic-like behaviors, social deficits, repetitive hyperactivity, anxiety-like behaviors. However, cell-type-specific contributions to these behaviors have remained largely unclear. Here, we deleted specific cell types found that male lacking neurons CaMKII-Cre;Shank2 fl/fl show...
Abstract When subjected to stress, some individuals develop maladaptive symptoms whereas others retain normal behavior. The medial prefrontal cortex (mPFC) is known control these adaptive responses stress. Here, we show that mPFC neurons in the left hemisphere stress effects on social Mice made socially avoidant by of chronic defeats showed depressed neural activity mPFC. Photoactivation reversed avoidance and restored activity. Despite defeats, resilient mice with sociability firing rates...
Abstract NMDA receptor (NMDAR) and GABA neuronal dysfunctions are observed in animal models of autism spectrum disorders, but how these impair social cognition behavior remains unclear. We report here that NMDARs cortical parvalbumin (Pv)-positive interneurons cooperate with gap junctions to promote high-frequency (>80 Hz) Pv burst firing cognition. Shank2 –/– mice, displaying improved sociability upon NMDAR activation, show impaired representation inhibitory firing. Cortical neurons...
Shank2 is an abundant postsynaptic scaffolding protein implicated in neurodevelopmental and psychiatric disorders, including autism spectrum disorders (ASD). Deletion of mice has been shown to induce social deficits, repetitive behaviors, hyperactivity, but the identity cell types that contribute these phenotypes remained unclear. Here, we report a conditional mouse line with deletion restricted parvalbumin (PV)-positive neurons (Pv-Cre;Shank2fl/fl mice). These display moderate hyperactivity...
<title>Abstract</title> Social interaction inherently requires the dynamic integration of information about oneself, others and shared environment. Although synchronized neural activity, or interbrain synchrony, between medial prefrontal cortices (mPFC) interacting individuals has been observed in both humans animals, its precise role social remains largely unexplored. Here, we show that Shank2 mutant (Shank2-/-) mice, which exhibit deficits, also display significant disruptions mPFC...
<title>Abstract</title> Social interaction requires the integration of information about oneself, others, and shared environment. One proposed mechanism for this coordination is interbrain synchrony – correlated neural activity between interacting individuals –observed in both humans animals. However, whether plays a functional role orchestrating social behavior remains unclear. Here, we show that theta-band synchronization medial prefrontal cortex (mPFC) essential naturalistic interactions...
Netrin-G ligand-3 (NGL-3) is a postsynaptic adhesion molecule known to directly interact with the excitatory scaffolding protein density-95 (PSD-95) and trans-synaptically leukocyte common antigen-related (LAR) family receptor tyrosine phosphatases regulate presynaptic differentiation. Although NGL-3 has been implicated in regulation of synapse development by vitro studies, whether it regulates or function, any other features brain not known. Here, we report that mice lacking (Ngl3−/− mice)...
Protocadherin19 (
Social deficit is a major feature of neuropsychiatric disorders, including autism spectrum schizophrenia, and attention-deficit/hyperactivity disorder, but its neural mechanisms remain unclear. Here, we examined neuronal discharge characteristics in the medial prefrontal cortex (mPFC) IRSp53/Baiap2-mutant mice, which show social deficits, during approach. We found decrease proportion IRSp53-mutant excitatory mPFC neurons encoding information, not that non-social information. In addition,...
Shank2 is an abundant postsynaptic scaffolding protein that known to regulate excitatory synapse assembly and synaptic transmission has been implicated in various neurodevelopmental disorders, including autism spectrum disorders (ASD). Previous studies on -mutant mice provided mechanistic insights into their autistic-like phenotypes, but it remains unclear how transcriptomic patterns are changed brain regions of the mutant age- gene dosage-dependent manners. To this end, we performed RNA-Seq...
Shank2 is an abundant postsynaptic scaffolding protein implicated in neurodevelopmental and psychiatric disorders, including autism spectrum disorders (ASD). Deletion of mice has been shown to induce social deficits, repetitive behaviors, hyperactivity, but the identity cell types that contribute these phenotypes remained unclear. Here, we report a conditional mouse line with deletion restricted parvalbumin (PV)-positive neurons (Pv-Cre;Shank2fl/fl mice). These display moderate hyperactivity...
Abstract Social deficit is a major feature of neuropsychiatric disorders, including autism spectrum schizophrenia, and attention-deficit/hyperactivity disorder, but its neural mechanisms remain unclear. Here, we examined neuronal discharge characteristics in the medial prefrontal cortex (mPFC) IRSp53-mutant mice, which show social deficits, during approach. excitatory mPFC neurons displayed an increase baseline firing decreases variability dynamic range rates burst non-social target...