A5027402942- Neuropeptides and Animal Physiology
- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Synthesis and Biological Evaluation
- Synthesis and Catalytic Reactions
- Synthesis and Reactions of Organic Compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthetic Organic Chemistry Methods
- Eicosanoids and Hypertension Pharmacology
- Steroid Chemistry and Biochemistry
- Inorganic and Organometallic Chemistry
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Reactions
- Peptidase Inhibition and Analysis
- Synthesis of β-Lactam Compounds
- Carbohydrate Chemistry and Synthesis
- Veterinary Pharmacology and Anesthesia
- Mesoporous Materials and Catalysis
- Organic Chemistry Cycloaddition Reactions
- Chemical Reaction Mechanisms
University of Southern California
2007
Abbott Fund
1993-2007
University of Washington
1995-2000
Abbott (United Kingdom)
1995-2000
Abbott (United States)
1988-1997
Discovery Laboratories (United States)
1995-1996
Yale University
1982
University of Pittsburgh
1980
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLewis acid catalyzed cyclocondensations of functionalized dienes with aldehydesSamuel Danishefsky, James F. Kerwin Jr., and Susumu KobayashiCite this: J. Am. Chem. Soc. 1982, 104, 1, 358–360Publication Date (Print):January 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/ja00365a095https://doi.org/10.1021/ja00365a095research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of .beta.-lactams from substituted hydroxamic acidsMarvin J. Miller, Phillip G. Mattingly, Marjorie A. Morrison, and James F. Kerwin Jr.Cite this: Am. Chem. Soc. 1980, 102, 23, 7026–7032Publication Date (Print):November 5, 1980Publication History Published online1 May 2002Published inissue 5 November 1980https://pubs.acs.org/doi/10.1021/ja00543a021https://doi.org/10.1021/ja00543a021research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the addition of allyltrimethylsilane to glycal acetatesSamuel Danishefsky and James F. Kerwin Jr.Cite this: J. Org. Chem. 1982, 47, 19, 3803–3805Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://doi.org/10.1021/jo00140a053RIGHTS & PERMISSIONSArticle Views789Altmetric-Citations126LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum full text article...
Abstract: Some data suggest that the sodium‐dependent, high‐affinity L‐glutamate (Glu) transport sites in forebrain are different from those cerebellum. In present study, sodium‐dependent of L‐[ 3 H]Glu was characterized cerebellum and cortex. both cerebellar cortical tissue, activity enriched synaptosomes. Approximately 100 excitatory amino acid analogues were tested as potential inhibitors activity. Many compounds inhibited by <65% at 1 m M not studied further. One group exhibited...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies in the Quinoline Series. VII. The Preparation of Some α-Dialkylaminomethyl-8-quinoline Methanols1Kenneth N. Campbell, James F. Kerwin, Raymond A. LaForge, and Barbara K. CampbellCite this: J. Am. Chem. Soc. 1946, 68, 9, 1844–1846Publication Date (Print):September 1, 1946Publication History Published online1 May 2002Published inissue 1 September 1946https://doi.org/10.1021/ja01213a046RIGHTS & PERMISSIONSArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCram rule selectivity in the Lewis acid catalyzed cyclocondensation of chiral aldehydes. A convenient route to systems biological interestSamuel Danishefsky, Susumu Kobayashi, and James F. Kerwin Jr.Cite this: J. Org. Chem. 1982, 47, 10, 1981–1983Publication Date (Print):May 1, 1982Publication History Published online1 May 2002Published inissue 1 1982https://pubs.acs.org/doi/10.1021/jo00349a037https://doi.org/10.1021/jo00349a037research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemical consequences of the Lewis acid catalyzed cyclocondensation oxygenated dienes with aldehydes. A rapid and stereoselective entry to various natural products derived from propionateSamuel Danishefsky, Nobuo Kato, David Askin, James F. Kerwin Jr.Cite this: J. Am. Chem. Soc. 1982, 104, 1, 360–362Publication Date (Print):January 1982Publication History Published online1 May 2002Published inissue 1 January...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTClaisen rearrangements of lactonic (silyl) enolates: a new route to functionalized cycloalkenesSamuel Danishefsky, Raymond L. Funk, and James F. Kerwin Jr.Cite this: J. Am. Chem. Soc. 1980, 102, 22, 6889–6891Publication Date (Print):October 15, 1980Publication History Published online1 May 2002Published inissue 15 October 1980https://pubs.acs.org/doi/10.1021/ja00542a058https://doi.org/10.1021/ja00542a058research-articleACS PublicationsRequest reuse...
An isosteric series of benzazoles was compared for their ability to produce paralysis in animals various species. 1. The effects produced by the were a mixture stimulation and depression. stimulating usually first occur, subsequently followed depressant which predominant. 2. substituted 2-aminobenzothiazoles particular paralyzing agents high potency. Methyl or chloro groups benzene ring 2-aminobenzothiazole depression according following order substitution: position 6 > 5 4 7....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRearrangement of 1,2-AminochloroalkanesJames F. Kerwin, Glenn E. Ullyot, Reynold C. Fuson, and Charles L. ZirkleCite this: J. Am. Chem. Soc. 1947, 69, 12, 2961–2965Publication Date (Print):December 1, 1947Publication History Published online1 May 2002Published inissue 1 December 1947https://pubs.acs.org/doi/10.1021/ja01204a009https://doi.org/10.1021/ja01204a009research-articleACS PublicationsRequest reuse permissionsArticle...
Abstract This study sought to determine whether the activity of nitric oxide synthase (NOS) is an important physiological link required mediate increases in cortical cerebral blood flow (CBF) elicited by electrical microstimulation basal forebrain (BF). Changes CBF were assessed urethane anesthetized rats using laser‐Doppler flowmetry. Microstimulation BF stimulus‐locked that dependent on frequency and current intensity (up 280% control at 50 Hz). Infusion potent NOS inhibitor N G...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA facile synthesis of substituted N-hydroxy-2-azetidinones. A biogenetic type .beta.-lactam synthesisPhillip G. Mattingly, James F. Kerwin Jr., and Marvin J. MillerCite this: Am. Chem. Soc. 1979, 101, 14, 3983–3985Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/ja00508a056https://doi.org/10.1021/ja00508a056research-articleACS PublicationsRequest reuse...
Nontypeable Haemophilus influenzae (NTHi), a human respiratory tract pathogen, can form colony biofilms in vitro. Bacterial cells and the amorphous extracellular matrix (ECM) constituting biofilm be separated using sonication. The ECM from 24- 96-h NTHi contained polysaccharides proteinaceous components as detected by nuclear magnetic resonance (NMR) Fourier transform infrared spectroscopy (FTIR) spectroscopy. More conventional chemical assays on confirmed presence of these also DNA....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies in the Quinoline Series. V. The Preparation of Some α-Dialkylaminomethyl-2-quinolinemethanols1Kenneth N. Campbell, Clarence H. Helbing, and James F. KerwinCite this: J. Am. Chem. Soc. 1946, 68, 9, 1840–1843Publication Date (Print):September 1, 1946Publication History Published online1 May 2002Published inissue 1 September 1946https://pubs.acs.org/doi/10.1021/ja01213a045https://doi.org/10.1021/ja01213a045research-articleACS...
Oxytocin, bradykinin, melittin and A23187 increased cyclic GMP levels through activation of soluble guanylate cyclase in cultured porcine kidney epithelial cells, LLC-PK1. NG-monomethyl-L-arginine, an inhibitor endothelium-derived relaxing factor/nitric oxide formation, decreased both basal stimulated a concentration-dependent manner. L-Arginine, but not D-arginine, augmented as well prevented the inhibition induced by NG-monomethyl-L-arginine. Similar effects L-arginine were also observed...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the Lewis acid catalyzed cyclocondensation of silyloxydienes with .alpha.,.beta.-unsaturated aldehydesSamuel Danishefsky and James F. Kerwin Jr.Cite this: J. Org. Chem. 1982, 47, 16, 3183–3184Publication Date (Print):July 1, 1982Publication History Published online1 May 2002Published inissue 1 July 1982https://pubs.acs.org/doi/10.1021/jo00137a035https://doi.org/10.1021/jo00137a035research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of C-18 Functionalized Steroid Hormone Analogs. II. Preparation and Some Reactions 18-Chloro Steroids1aJames F. Kerwin, Manfred E. Wolff, Franklin Owings, Barbara B. Lewis, Benjamin Blank, A. Magnani, C. Karash, V. GeorgianCite this: J. Org. Chem. 1962, 27, 10, 3628–3639Publication Date (Print):October 1, 1962Publication History Published online1 May 2002Published inissue 1 October...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE SYNTHESIS OF C-18 FUNCTIONALIZED STEROID HORMONE ANALOGS. I. A PARTIAL ALDOSTERONEManfred E. Wolff, James F. Kerwin, Franklin Owings, Barbara B. Lewis, Blank, A. Magnani, and V. GeorgianCite this: J. Am. Chem. Soc. 1960, 82, 15, 4117–4118Publication Date (Print):August 1, 1960Publication History Published online1 May 2002Published inissue 1 August...